Download Colloids, Complex Fluids, and Soft Condensed Matter

Carlos Montalvo
Foy H. Moody High School; Corpus Christi ISD
Faculty Mentor: Dr. Zhengdong Cheng
Artie McFerrin Dept. of Chemical Engineering
 B.S., University of Science and
Technology of China, Hefei, China,
1990
 M.S., Institute of High Energy Physics,
Beijing, China, 1993
 Ph.D., Princeton University, 1999
 Postdoc, ExxonMobil, 1999-2000
 DiCon Fiberoptics Inc., 2001-2002
 Postdoc, Harvard Universtiy, 20022004
 Colloid Chemistry

Colloid—type of mechanical mixture where one
substance is dispersed evenly throughout
another.
Aspects of Research
 Colloidal Crystal Growth

Engineering and ordering large crystals to create
photonic band gaps for optical computers
 Discotic Colloids

Study the flow and movement of disk like
molecules such as red blood cells
 Cell Encapsulation

Using microreactors to create a protective
“bubble” over a cell for possible drug delivery
Crystal Structure Review
How are Colloids and Crystal
structures related?
 Colloidal Crystals!!
0 min
25 min
4 min
89 min
11 min
152 min
Reason for Understanding
Colloidal Crystals
 Optical Computers
Optical Computer
Discotic Colloids
 Emulsification—process by which one liquid
is dispersed into another in the form of small
droplets (http://www.pwsrcac.org/resources/glossary.html)
• Wax with 1%
STADIS-450
• Flow Rate : 4ml/h
• Voltage: 2.8 kV
Electrospray
 Electrospray


Ionization technique
where droplets are
created in an electric
field
An electric force is
applied to a liquid
surface
Wax Emulsion
 Eicosene (wax)


Formation of
droplets
Lower
temperature to
form disks
Disk Forming
 Electrospray cooling forms disks similar to
shape of Red Blood Cell
Cell Encapsulation
 Placing a cell into a protective membrane
that is not immunosuppressed.
Cell Encapsulation: concept
 Encapsulate cells of interest in
semi-permeable membrane
 Implant cell capsules
 Cells release therapeutic
substances
 Advantages
 Immunoisolation
 Natural therapeutic response
 Applications
 Diabetes (type I)
 Hemophilia
 Cancer
 Renal failure
Dr. Dawei Luo
Cell Encapsulation
 Confocal microscope
imaging shows the
uniform shape of
alginate disks.
 Fluorescence shows
successful
encapsulation of
colloidal particles.
Microfluidics
 Microfluidics
water
oil
oil
oil
oil
water
Microfluidics
 Microreactors using microfluidics
Experiments to be Conducted
 Formation of microdisks using Electrospray
technique
Droplet Formation Using
Electrospray
Experiments to be Conducted
 Study the size and variation of the wax disks
as electrospray settings are changed
 Study how the disks flow through various
substances (ie.—red blood cell flow)
 Observe and study encapsulation techniques
 Attempt to add protective coating to
encapsulations
 Aspects of Research



Colloidal crystal growth
Disk formation using Electrospray
Cell encapsulation using Electrospray and
microfluidics
 Classroom Activities???
 Dr. Zhengdong Cheng
 Andres Mejia
 Lucas Kinard
 National Science Foundation