Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download Here we can focus directly on the input neurons, the Schaffer
Document related concepts
Apical dendrite wikipedia , lookup
Axon guidance wikipedia , lookup
Brain-derived neurotrophic factor wikipedia , lookup
End-plate potential wikipedia , lookup
Feature detection (nervous system) wikipedia , lookup
Long-term potentiation wikipedia , lookup
Synaptic gating wikipedia , lookup
Pre-Bötzinger complex wikipedia , lookup
Neurotransmitter wikipedia , lookup
Nonsynaptic plasticity wikipedia , lookup
Long-term depression wikipedia , lookup
Chemical synapse wikipedia , lookup
Neuromuscular junction wikipedia , lookup
Stimulus (physiology) wikipedia , lookup
Endocannabinoid system wikipedia , lookup
Activity-dependent plasticity wikipedia , lookup
Molecular neuroscience wikipedia , lookup
Synaptogenesis wikipedia , lookup
Signal transduction wikipedia , lookup
NMDA receptor wikipedia , lookup
Transcript
Herewecanfocusdirectlyontheinputneurons,theSchaffercollateralsendingontheCA1 pyramidalcells.Wenowseeontherighthandsidethisisthewholesynapticcell,noticeweare nowfocusingonthepost-synapticcell.Theearlychangeforexplicitmemorystorageisgoingto haveapullsynaptictargetratherthanapsynaptictarget.TheSchaffercollateralscomein,they releaseglutamatejustaswesawinthesensoryneuronsinaplysia.Theyactontwodifferent kindsofreceptorstoglutamates.AreceptorcalledNMDAreceptor,andareceptorcalledthe AMPAreceptor.UndernormalcircumstancesonlytheAMPAreceptorisactive.Butifyougivea trainofstimuli,theNMDAreceptorbecomesactive,itflexescalcium,itallowscalciumtocome intothecells.Calciumactivatesasecondmessengerkinase,butadifferentonethanacyclic AMPdependentkinase.Acalciumsensitivekinasecalledthecalciumcalmodulindependent proteinkinase.ItactsbyinsertingadditionalAMPAreceptorsintothepost-synapticcell.And thatisthemechanismforshort-termsynapticplasticityinLTPinthehippocampus.Apost synapticmechanisminvolvingCAMkinaseinsertingnewAMPAreceptors.
