Molecular and Cellular Mechanisms of Reelin Signaling in the Adult
... pave the path for new disciplines. Finally, the most recent and formative phase of my metamorphosis, has been under the tutelage of Dr. Edwin Weeber, who has provided unbridled support for my countless curiosities and epitomized the loving mentor that every graduate student longs for. One of the mos ...
... pave the path for new disciplines. Finally, the most recent and formative phase of my metamorphosis, has been under the tutelage of Dr. Edwin Weeber, who has provided unbridled support for my countless curiosities and epitomized the loving mentor that every graduate student longs for. One of the mos ...
Memantine is a clinically well tolerated N-methyl-D
... The antagonistic effects of memantine at −70 mV were not influenced by increasing concentrations of glycine (Parsons et al., 1993). Thus, antagonism via interactions at the glycineB site is unlikely. However, it is possible that memantine increases the affinity of glycine at NMDA receptors as reflec ...
... The antagonistic effects of memantine at −70 mV were not influenced by increasing concentrations of glycine (Parsons et al., 1993). Thus, antagonism via interactions at the glycineB site is unlikely. However, it is possible that memantine increases the affinity of glycine at NMDA receptors as reflec ...
5-HT Receptor Regulation of Neurotransmitter Release
... as prefrontal neocortical dopamine or neocortical acetylcholine release, respectively. Conversely, attenuated GABA release in response to activation of inhibitory 5-HT heteroreceptors, e.g., 5-HT1A or 5-HT1B receptors on GABAergic interneurons is involved in paradoxical facilitation of hippocampal a ...
... as prefrontal neocortical dopamine or neocortical acetylcholine release, respectively. Conversely, attenuated GABA release in response to activation of inhibitory 5-HT heteroreceptors, e.g., 5-HT1A or 5-HT1B receptors on GABAergic interneurons is involved in paradoxical facilitation of hippocampal a ...
PDF - Oxford Academic - Oxford University Press
... Moreover, dendritic filopodia rapidly extend toward nearby axonal growth cones to form synaptic connections, implying that dendrites may be a much more active force in synapse formation than previously imagined (Cooper and Smith, 1992; Ziv and Smith, 1996; Jontes et al., 2000). Many dendritic filopo ...
... Moreover, dendritic filopodia rapidly extend toward nearby axonal growth cones to form synaptic connections, implying that dendrites may be a much more active force in synapse formation than previously imagined (Cooper and Smith, 1992; Ziv and Smith, 1996; Jontes et al., 2000). Many dendritic filopo ...
Functional Selectivity and Antidepressant Activity of Serotonin 1A
... temperature regulation, pain, and cognition as well as in pathological states including disorders connected to mood, anxiety, psychosis and pain. 5-HT1A receptors has for a long time been considered as an interesting target for the action of antidepressant drugs. It was postulated that postsynaptic ...
... temperature regulation, pain, and cognition as well as in pathological states including disorders connected to mood, anxiety, psychosis and pain. 5-HT1A receptors has for a long time been considered as an interesting target for the action of antidepressant drugs. It was postulated that postsynaptic ...
... Neurotrophins (NTs) are a unique family of structurally related polypeptide growth factors that influence the development, maintenance, survival, repair and death of neuronal and non neuronal cells in the nervous system. Members belonging to this group include NGF, BDNF, NT-3 and NT 4/5. They exert ...
Subunit Composition of N-Methyl-D
... Department of Pharmacology, Georgetown University School of Medicine, Washington, D.C. 20007 Received September 24, 1997; Accepted November 27, 1997 ...
... Department of Pharmacology, Georgetown University School of Medicine, Washington, D.C. 20007 Received September 24, 1997; Accepted November 27, 1997 ...
Glia-Derived D-Serine Controls NMDA Receptor Activity and
... at the strychnine-insensitive glycine site of NMDA receptors (NMDARs; Johnson and Ascher, 1987). D-serine is synthesized in astrocytes (Stevens et al., 2003; Wolosker et al., 1999) and is released by glutamate receptor stimulation through a calcium- and SNARE-dependent exocytotic pathway (Mothet et ...
... at the strychnine-insensitive glycine site of NMDA receptors (NMDARs; Johnson and Ascher, 1987). D-serine is synthesized in astrocytes (Stevens et al., 2003; Wolosker et al., 1999) and is released by glutamate receptor stimulation through a calcium- and SNARE-dependent exocytotic pathway (Mothet et ...
Synaptic plasticity: taming the beast
... processes that are sensitive to the postsynaptic firing rate or to the total level of synaptic efficacy. A frequent approach in neural network models is to globally adjust all the synapses onto each postsynaptic neuron based on its level of activity3. The adjustment can take two forms, depending on ...
... processes that are sensitive to the postsynaptic firing rate or to the total level of synaptic efficacy. A frequent approach in neural network models is to globally adjust all the synapses onto each postsynaptic neuron based on its level of activity3. The adjustment can take two forms, depending on ...
Calcium Regulation of Dendritic Growth via CaM Kinase IV and
... dendritic arbor rapidly expands over the subsequent few days (Wu et al., 1999). During this period of rapid dendritic growth, synaptic currents are principally mediated by NMDA receptors, and pharmacological blockade of NMDA receptors markedly reduces dendritic growth rates (Rajan and Cline, 1998). ...
... dendritic arbor rapidly expands over the subsequent few days (Wu et al., 1999). During this period of rapid dendritic growth, synaptic currents are principally mediated by NMDA receptors, and pharmacological blockade of NMDA receptors markedly reduces dendritic growth rates (Rajan and Cline, 1998). ...
Disease Modeling Using Embryonic Stem Cells
... begin to express synaptic markers at similar rates, we monitored between day 1 and day 21 the levels of synaptophysin, a protein associated with presynaptic vesicles. As previously reported, these levels increase dramatically during the second week of neuronal maturation (Fig. 1D, 1E), reflecting sy ...
... begin to express synaptic markers at similar rates, we monitored between day 1 and day 21 the levels of synaptophysin, a protein associated with presynaptic vesicles. As previously reported, these levels increase dramatically during the second week of neuronal maturation (Fig. 1D, 1E), reflecting sy ...
166 - UCSF Physiology - University of California, San Francisco
... Integrins are a large family of cell adhesion receptors involved in a variety of cellular functions. To study their roles at central synapses, we used two cre recombinase lines to delete the Itgb1 1 integrin gene in forebrain excitatory neurons at different developmental stages. Removal of the 1 i ...
... Integrins are a large family of cell adhesion receptors involved in a variety of cellular functions. To study their roles at central synapses, we used two cre recombinase lines to delete the Itgb1 1 integrin gene in forebrain excitatory neurons at different developmental stages. Removal of the 1 i ...
Zinc Alters Excitatory Amino Acid Neurotoxicity on Cortical Neurons
... myriad metabolic processes(Vallee, 1959), histochemicalmethods have revealed foci of chelatableZn (Danscher et al., 198.5), specifically in forebrain neuropil (Haug, 1973), and ultrastructural studies have further suggestedthat much of this Zn is located within certain synaptic vesicles in excitator ...
... myriad metabolic processes(Vallee, 1959), histochemicalmethods have revealed foci of chelatableZn (Danscher et al., 198.5), specifically in forebrain neuropil (Haug, 1973), and ultrastructural studies have further suggestedthat much of this Zn is located within certain synaptic vesicles in excitator ...
Structural Changes in AMPA-Receptive Neurons in the Nucleus of
... rats, which was attributable to an increase in the proportion of dendritic spines containing GluR1 as well as an increase in the total number of dendritic spines. The differences were only seen after the development of hypertension and were not seen in rostral regions of the nucleus of the solitary ...
... rats, which was attributable to an increase in the proportion of dendritic spines containing GluR1 as well as an increase in the total number of dendritic spines. The differences were only seen after the development of hypertension and were not seen in rostral regions of the nucleus of the solitary ...
University of Birmingham Drosophila neurotrophins reveal a
... also control cell proliferation and neuronal differentiation, and they are required for axonal and dendritic elaborations, synaptic plasticity, excitability, and long-term potentiation (LTP, the basis of memory and learning) [2–5]. NTs underlie most aspects of vertebrate nervous system development a ...
... also control cell proliferation and neuronal differentiation, and they are required for axonal and dendritic elaborations, synaptic plasticity, excitability, and long-term potentiation (LTP, the basis of memory and learning) [2–5]. NTs underlie most aspects of vertebrate nervous system development a ...
Expression of AMPA/kainate receptors during development of chick
... et al., 1998) and by desensitising due to extracellular protons (Ihle and Patneau, 2000) (for review see Zorumski and Thio, 1992; Bleakman and Lodge, 1998). Calcium currents induced by glutamate, alter during maturation of cortical and hippocampal neurons in culture (Wahl et al., 1989; Barish and Ma ...
... et al., 1998) and by desensitising due to extracellular protons (Ihle and Patneau, 2000) (for review see Zorumski and Thio, 1992; Bleakman and Lodge, 1998). Calcium currents induced by glutamate, alter during maturation of cortical and hippocampal neurons in culture (Wahl et al., 1989; Barish and Ma ...
Retrograde Signaling in the Development and Modification of
... NGF-like molecules, each specific for different but overlapping populations of neurons. Other members of this NGF family of factors, or neurotrophins, now include brain-derived neurotrophic factor (BDNF), neurotrophin (NT)-3, NT-4/5, and NT-6 (213, 215). In addition to their traditional role as surv ...
... NGF-like molecules, each specific for different but overlapping populations of neurons. Other members of this NGF family of factors, or neurotrophins, now include brain-derived neurotrophic factor (BDNF), neurotrophin (NT)-3, NT-4/5, and NT-6 (213, 215). In addition to their traditional role as surv ...
Brain stem excitatory and inhibitory signaling pathways regulating
... the coordinated control of cardiac rate, atrioventricular conduction, and left ventricular contractility (65, 133, 134). Recent preliminary data in ferrets suggest that presumptive gap junctions between identified AVPNs (Blinder K, Karibi-Ikiriko A, Massari VJ, Haxhiu MA, unpublished data) may serve ...
... the coordinated control of cardiac rate, atrioventricular conduction, and left ventricular contractility (65, 133, 134). Recent preliminary data in ferrets suggest that presumptive gap junctions between identified AVPNs (Blinder K, Karibi-Ikiriko A, Massari VJ, Haxhiu MA, unpublished data) may serve ...
Transgenic mice overexpressing the full
... the locus coreuleus (LC), may participate in the exaggerated stimulus-responsiveness and increased emotionality seen in patients with stress or anxiety disorders (Priolo et al., 1991; Aston-Jones et al., 1996; Goddard and Charney, 1997). On the other hand, antidepressant treatment, that is effective ...
... the locus coreuleus (LC), may participate in the exaggerated stimulus-responsiveness and increased emotionality seen in patients with stress or anxiety disorders (Priolo et al., 1991; Aston-Jones et al., 1996; Goddard and Charney, 1997). On the other hand, antidepressant treatment, that is effective ...
MECHANISMS OF VERTEBRATE SYNAPTOGENESIS
... Signaling pathways involved in regulating vertebrate synaptogenesis. Synaptogenesis is a multistep process involving a myriad of signaling molecules. Prior to synapse formation, secreted molecules such as netrins and semaphorins guide axons to their targets. These axons then encounter priming factor ...
... Signaling pathways involved in regulating vertebrate synaptogenesis. Synaptogenesis is a multistep process involving a myriad of signaling molecules. Prior to synapse formation, secreted molecules such as netrins and semaphorins guide axons to their targets. These axons then encounter priming factor ...
Ethanol Neurotoxicity in the Developing Cerebellum
... Ethanol also significantly inhibited the DNA-binding activity of RAR and increased the activity of RXR to a consensus DNA-response element [48]. Studies have demonstrated that RXR targets genes predominantly involved in apoptosis [49,50], while RAR regulates genes promoting neuronal differentiation ...
... Ethanol also significantly inhibited the DNA-binding activity of RAR and increased the activity of RXR to a consensus DNA-response element [48]. Studies have demonstrated that RXR targets genes predominantly involved in apoptosis [49,50], while RAR regulates genes promoting neuronal differentiation ...
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... sustained independently of neurotrophins and is downregulated by BDNF. With the acquisition of NGF dependence, p75 and trkA mRNA levels increase markedly in vivo. At this stage in vitro, the level of p75 mRNA is upregulated by NGF, but this response is lost at later stages. ...
... sustained independently of neurotrophins and is downregulated by BDNF. With the acquisition of NGF dependence, p75 and trkA mRNA levels increase markedly in vivo. At this stage in vitro, the level of p75 mRNA is upregulated by NGF, but this response is lost at later stages. ...
NMDA Receptors Contribute to Primary Visceral Afferent
... synaptic transmission in the NTS may be due to true differences in the glutamate receptor subtypes activated in these different autonomic reflex pathways or to limitations of the microinjection technique, which typically relies on relatively large volumes (10–100 nl) of highly concentrated agents th ...
... synaptic transmission in the NTS may be due to true differences in the glutamate receptor subtypes activated in these different autonomic reflex pathways or to limitations of the microinjection technique, which typically relies on relatively large volumes (10–100 nl) of highly concentrated agents th ...
Synaptic function: Dendritic democracy
... postsynaptic receptors change with distance from the soma. Evidence from the goldfish Mauthner cell indicates that the size of postsynaptic glycine receptor clusters increases with distance from the soma [7]. In CA1 pyramidal neurons, experiments using local uncaging of caged glutamate have shown th ...
... postsynaptic receptors change with distance from the soma. Evidence from the goldfish Mauthner cell indicates that the size of postsynaptic glycine receptor clusters increases with distance from the soma [7]. In CA1 pyramidal neurons, experiments using local uncaging of caged glutamate have shown th ...
ELECTRODEPOSITION OF ALLOYS, 1930 TO 1940.1 By Ci
... and chemoreflex unaffected (28). We have also demonstrated that activation of 5-HT1A receptors in the RVLM results in a potent, selective inhibition of the somato-sympathetic reflex but not the baroreflex or chemoreflex (27). The undecapeptide tachykinin substance P and its receptor, the neurokinin ...
... and chemoreflex unaffected (28). We have also demonstrated that activation of 5-HT1A receptors in the RVLM results in a potent, selective inhibition of the somato-sympathetic reflex but not the baroreflex or chemoreflex (27). The undecapeptide tachykinin substance P and its receptor, the neurokinin ...