BDNF-modulated Spatial Organization of Cajal
... early-generated ‘pioneer neurons’ has recently been described (Morante-Oria et al., 2003); this population does not express reelin or GABA, but can be identified by TAG1 expression and possesses a subpallial origin. Neurotrophins are a family of peptide growth factors regulating neuronal survival, sy ...
... early-generated ‘pioneer neurons’ has recently been described (Morante-Oria et al., 2003); this population does not express reelin or GABA, but can be identified by TAG1 expression and possesses a subpallial origin. Neurotrophins are a family of peptide growth factors regulating neuronal survival, sy ...
Regulation of neuronal survival and death by extracellular signals
... 1996; Wilkinson et al., 1996). Although this switch in responsiveness is due in part to the sequential generation of BDNF-responsive and NGF-responsive neurons in the ganglion (Enokido et al., 1999; Huang et al., 1999a), bromodeoxyuridine (BrdU) labelling studies have demonstrated that many of the n ...
... 1996; Wilkinson et al., 1996). Although this switch in responsiveness is due in part to the sequential generation of BDNF-responsive and NGF-responsive neurons in the ganglion (Enokido et al., 1999; Huang et al., 1999a), bromodeoxyuridine (BrdU) labelling studies have demonstrated that many of the n ...
Full text - Ip Lab - Hong Kong University of Science and Technology
... changes in neuronal connections, which underlies longlasting changes in synaptic strength during the formation of long-term memory. It is well established that trans-synaptic interaction of adhesion molecules is crucial for synaptogenesis. The homophilic or heterophilic interaction between adhesion ...
... changes in neuronal connections, which underlies longlasting changes in synaptic strength during the formation of long-term memory. It is well established that trans-synaptic interaction of adhesion molecules is crucial for synaptogenesis. The homophilic or heterophilic interaction between adhesion ...
Involvement of Tumor Necrosis Factor Alpha in Hippocampal
... performance of affected mice in behavioral tasks related to spatial memory. Moreover, lack of TNFα increased the expression of nerve growth factor (NGF), but not brain-derived neurotrophic factor (BDNF), following performance of the learning task. Our results suggest that TNFα actively influences hi ...
... performance of affected mice in behavioral tasks related to spatial memory. Moreover, lack of TNFα increased the expression of nerve growth factor (NGF), but not brain-derived neurotrophic factor (BDNF), following performance of the learning task. Our results suggest that TNFα actively influences hi ...
Nerve Regeneration in the Cornea
... • Clinical studies have shown that corneal nerves regenerate over several years after surgical transection; however, the nerve density never returns to presurgery values. • Subbasal nerve density decreased by 82% in 5 days after LASIK. A gradual increase in density was observed at 2 weeks after surg ...
... • Clinical studies have shown that corneal nerves regenerate over several years after surgical transection; however, the nerve density never returns to presurgery values. • Subbasal nerve density decreased by 82% in 5 days after LASIK. A gradual increase in density was observed at 2 weeks after surg ...
Signalling organelle for retrograde axonal transport of
... Received 10 April 2000; accepted 10 April 2000. ...
... Received 10 April 2000; accepted 10 April 2000. ...
Document
... (PI 3 kinase) cascades, which result in regulating the differentiation and survival of neurons, are activated. The binding to the receptors Trks or p75 is related to ...
... (PI 3 kinase) cascades, which result in regulating the differentiation and survival of neurons, are activated. The binding to the receptors Trks or p75 is related to ...
Different neurotrophins are expressed and act in a developmental
... response to BDNF and NT-3 prior to naturally occurring cell death The survival effects of neurotrophins on cultured embryonic trigeminal neurons are clearly observed after 48 hours incubation when virtually all neurons have died in control cultures. Furthermore, since the serum-free medium used in t ...
... response to BDNF and NT-3 prior to naturally occurring cell death The survival effects of neurotrophins on cultured embryonic trigeminal neurons are clearly observed after 48 hours incubation when virtually all neurons have died in control cultures. Furthermore, since the serum-free medium used in t ...
2011 CSH - Harvard University
... vision shapes the synaptic organization of visual cortex during a critical period in postnatal life (Hubel 1982; Wiesel 1982). Although the gross arrangement of axonal projections from the two eyes into alternating ocular dominance columns in the visual cortex is present prior to eye opening (Crowle ...
... vision shapes the synaptic organization of visual cortex during a critical period in postnatal life (Hubel 1982; Wiesel 1982). Although the gross arrangement of axonal projections from the two eyes into alternating ocular dominance columns in the visual cortex is present prior to eye opening (Crowle ...
NMDA and AMPA Receptors: Development and Status Epilepticus
... unique area- and temporal-expression pattern, therefore AMPA receptor subunits transcripts appear to be independently regulated during development (Lilliu et al. 2001). If an AMPAR lacks a GluR2 subunit, then it will be permeable to sodium, potassium and calcium, but presence of a GluR2 subunit will ...
... unique area- and temporal-expression pattern, therefore AMPA receptor subunits transcripts appear to be independently regulated during development (Lilliu et al. 2001). If an AMPAR lacks a GluR2 subunit, then it will be permeable to sodium, potassium and calcium, but presence of a GluR2 subunit will ...
Distinct Roles for Somatically and Dendritically Synthesized Brain
... antibody to GFP at DIV14, DIV21, DIV28, DIV35, and DIV42, as described above. All dendritic spines on one entire main dendrite per neuron (⬎180 m in length) were traced directly under a Nikon Eclipse E800 microscope with an oil-immersion lens (Nikon; Plan APO 60⫻/NA 1.40) using Neurolucida software ...
... antibody to GFP at DIV14, DIV21, DIV28, DIV35, and DIV42, as described above. All dendritic spines on one entire main dendrite per neuron (⬎180 m in length) were traced directly under a Nikon Eclipse E800 microscope with an oil-immersion lens (Nikon; Plan APO 60⫻/NA 1.40) using Neurolucida software ...
Exercise and Anxiety Take Home Messages
... 5. Exercise → ↑ neurogenesis in the dorsal and ventral dentate gyrus (DG) a. DG is a tooth-shaped group of small round cells (granule cells) in the hippocampus i. Granule cells are excitatory – glutamatergic a) Connect to hippocampal CA3 pyramidal cells i) Via axons call mossy fibers ii) CA3 connect ...
... 5. Exercise → ↑ neurogenesis in the dorsal and ventral dentate gyrus (DG) a. DG is a tooth-shaped group of small round cells (granule cells) in the hippocampus i. Granule cells are excitatory – glutamatergic a) Connect to hippocampal CA3 pyramidal cells i) Via axons call mossy fibers ii) CA3 connect ...
Memory Extinction, Learning Anew, and Learning the New
... anterograde direction, though some moved retrogradely, and transferred to postsynaptic neurons in an activity-dependent manner. Neuronal activity modifies the formation of neural circuits in developing cerebral cortex (1–3). Neurotrophins such as BDNF are attractive candidates for molecular signals ...
... anterograde direction, though some moved retrogradely, and transferred to postsynaptic neurons in an activity-dependent manner. Neuronal activity modifies the formation of neural circuits in developing cerebral cortex (1–3). Neurotrophins such as BDNF are attractive candidates for molecular signals ...
Formation of a full complement of cranial proprioceptors requires
... outcome, two main subpopulations of TMN neurons may exist during embryogenesis, one dependent on TrkC/NT3 functioning and the other utilizing TrkB/BDNF signaling. The differential dependence of TMN neurons on neurotrophins may reflect differential accessibility of the neurons to limiting amounts of ...
... outcome, two main subpopulations of TMN neurons may exist during embryogenesis, one dependent on TrkC/NT3 functioning and the other utilizing TrkB/BDNF signaling. The differential dependence of TMN neurons on neurotrophins may reflect differential accessibility of the neurons to limiting amounts of ...
Plasticity-related genes in brain development and amygdala
... subsequently shown to contribute to plasticity underlying learning and memory in adulthood (Poo 2001; Sweatt 2001). A wealth of literature has since identified BDNF and ERK as key mediators of the plasticity necessary for learning in the amygdala, a brain region important in mediating learning about ...
... subsequently shown to contribute to plasticity underlying learning and memory in adulthood (Poo 2001; Sweatt 2001). A wealth of literature has since identified BDNF and ERK as key mediators of the plasticity necessary for learning in the amygdala, a brain region important in mediating learning about ...
Amyloid-Beta Induced Changes in Vesicular Transport of BDNF in
... fluorescently labeled BDNF. The dynamic behavior of BDNF-containing vesicles was analyzed by live cell imaging. (a) Representative picture of a hippocampal neuron transfected with BDNF-mCherry. (b) Boxed area from (a) at higher magnification and at different time points of time-lapse recording. Red ...
... fluorescently labeled BDNF. The dynamic behavior of BDNF-containing vesicles was analyzed by live cell imaging. (a) Representative picture of a hippocampal neuron transfected with BDNF-mCherry. (b) Boxed area from (a) at higher magnification and at different time points of time-lapse recording. Red ...
Developmental - Schizophrenia Research Forum
... the frontal cortex and hippocampus; prolonged corticosterone stress response and decreased expression of central corticosteroid receptors (sensitive to cross-fostering); increased basal dopamine and decreased noradrenaline output in the nucleus accumbens; decreased basal noradrenaline output in the ...
... the frontal cortex and hippocampus; prolonged corticosterone stress response and decreased expression of central corticosteroid receptors (sensitive to cross-fostering); increased basal dopamine and decreased noradrenaline output in the nucleus accumbens; decreased basal noradrenaline output in the ...
Functions of the Nervous System
... Conception: a kind of protein molecules that produced by the tissue( such as muscle ) and astrocytes, and is the necessary substance to the neuron survival and growth. Action mode: Neurotrophin enter into the terminal of axon by endocytosis, then reach to cell body by retrograde ...
... Conception: a kind of protein molecules that produced by the tissue( such as muscle ) and astrocytes, and is the necessary substance to the neuron survival and growth. Action mode: Neurotrophin enter into the terminal of axon by endocytosis, then reach to cell body by retrograde ...
New insights into the roles of microRNAs in drug addiction and
... and amphetamines) induce strong and persistent neuroadaptive changes through a surfeit of gene regulatory mechanisms leading to addiction. Activitydependent synaptic plasticity of the mesolimbic dopaminergic system, known as the ‘reward pathway’, plays a crucial role in the development of drug depen ...
... and amphetamines) induce strong and persistent neuroadaptive changes through a surfeit of gene regulatory mechanisms leading to addiction. Activitydependent synaptic plasticity of the mesolimbic dopaminergic system, known as the ‘reward pathway’, plays a crucial role in the development of drug depen ...
Neuromodulation of Aerobic Exercise—A Review
... into the bloodstream. This has inhibitory effects upon the hypothalamus and pituitary (Crosby and Bains, 2012) through medial prefrontal cortex (mPFC) receptors (Hill et al., 2011) and reduces stress-induced overexcitability of the amygdala (Gray et al., 2015). Completion of this circuit restores th ...
... into the bloodstream. This has inhibitory effects upon the hypothalamus and pituitary (Crosby and Bains, 2012) through medial prefrontal cortex (mPFC) receptors (Hill et al., 2011) and reduces stress-induced overexcitability of the amygdala (Gray et al., 2015). Completion of this circuit restores th ...
Glycemic State Regulates Brain-Derived Neurotrophic Factor
... system (CNS) (43; 115) and particular peripheral tissues including muscles (128), adipose (197), and liver (38). As a result, both proteins are widely distributed throughout the nervous system(43; 217) while, at the cellular level, BDNF and its receptors, TrkB and p75, can be located in both the axo ...
... system (CNS) (43; 115) and particular peripheral tissues including muscles (128), adipose (197), and liver (38). As a result, both proteins are widely distributed throughout the nervous system(43; 217) while, at the cellular level, BDNF and its receptors, TrkB and p75, can be located in both the axo ...
Brain-derived neurotrophic factor in the development of epilepsy
... Abstract Epilepsy is one of the most common neurological diseases, but our understanding of the detailed cellular and molecular mechanisms underlying it remains incomplete. Several pathological changes typically occur in the epileptic brain, including neuronal loss, neurogenesis, neurite growth, and ...
... Abstract Epilepsy is one of the most common neurological diseases, but our understanding of the detailed cellular and molecular mechanisms underlying it remains incomplete. Several pathological changes typically occur in the epileptic brain, including neuronal loss, neurogenesis, neurite growth, and ...
handout
... What are the major NT in the mammalian brain? Quantitatively, simple amino acids glutamate and GABA are the most abundant NT in the mammalian brain and mediate fast transmission in the CNS via iR. In general, although not always (during development), GABA is inhibitory whereas glutamate is excitator ...
... What are the major NT in the mammalian brain? Quantitatively, simple amino acids glutamate and GABA are the most abundant NT in the mammalian brain and mediate fast transmission in the CNS via iR. In general, although not always (during development), GABA is inhibitory whereas glutamate is excitator ...
Immunohistochemical Analysis of Trk Receptor Activation in Epilepsy
... Validation of CST pY490 Antibody For the immunohistochemical analysis presented below, a pY490 antibody (CST) raised to a tyrosine-phosphorylated peptide (IENPQY*FSD, from trkA sequence data) with an overlapping but distinct sequence from that of the Segal pY490 antibody was employed (Table 1). The ...
... Validation of CST pY490 Antibody For the immunohistochemical analysis presented below, a pY490 antibody (CST) raised to a tyrosine-phosphorylated peptide (IENPQY*FSD, from trkA sequence data) with an overlapping but distinct sequence from that of the Segal pY490 antibody was employed (Table 1). The ...