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June 2015 The Hong Kong Polytechnic University Hong Kong Community College Subject Description Form Subject Code CCN2254 Subject Title Cell Biology Level 2 Credit Value 3 Medium of Instruction English Pre-requisite / Co-requisite/ Exclusion Pre-requisite Objectives This subject equips students with the knowledge of the molecular basis of cellular structures and functions. Lectures focus on the biochemical function of cellular organelles, as well as the interactions of the cells with the extracellular environment. It provides an insight of how organelles maintain the homeostasis of the cell, and how various cells interact and maintain the organisms and hence the preservation of our internal environment. Intended Learning Outcomes Upon completion of the subject, students will be able to: CCN1109 General Biology or CCN2233 Human Biology I (a) describe the structural organisation of eukaryotic cells, including an introduction to the major types of subcellular organelles, their structures and functions. (b) relate the properties and functions of plasma membrane to its architecture. (c) explain the phenomena that are essential to cellular activities: energy transformations and the use of enzymes to catalyse chemical reactions. (d) integrate the working principles of different types of microscopy commonly used in cell biology and apply the techniques in different situations. (e) identify different signalling molecules involved in controlling a eukaryotic cell cycle. Subject Synopsis/ Indicative Syllabus Introduction to Cells and Chemistry of Cells Prokaryotes and eukaryotes; Importance of biomolecules in cells, bioenergetics and catalysis; Visualisation of cells and subcellular structures with different types of microscopy. 1 June 2015 Structure and Function of Cell Organelles The architecture of plasma membrane structure; Functions and transport across membrane; Internal membranes and cell energetic; cytoskeleton (actin and myosin, tubulin and microtubules) and cell movement; Function of endoplasmic reticulum, ribosomes, Golgi apparatus, mitochondrion, enzymes, motile structures (cilia, flagella and centromeres) and the nucleus. Cell Cycles and Development of Cell Specificity in Eukaryotes Cell cycle: mitosis and meiosis; Cells in early stage of development, cell lineage and differentiation, regulation in development and differentiation. Control of Cell Signalling Types of cell signalling; Basis and understanding of cell signalling, major types of signalling cascades. Teaching/Learning Methodology Lectures reinforce the knowledge of cellular structures and functions. The maintenance of the integrity of cell, the interaction of cells to preserve the internal environment for the organism, and the interaction of cell with the external environment will also be introduced. Lectures will be conducted in an interesting and interactive manner, and students will be encouraged to participate in class. Tutorials provide students with opportunities to broaden and reinforce the general knowledge obtained in the lectures. Students will be engaged in case studies, class discussions, video demonstration, and presentations to strengthen and back up the knowledge. Laboratory sessions enhance the knowledge learnt in lectures / tutorials with the introduction of some basic techniques of cell biology. Assessment Methods in Alignment with Intended Learning Outcomes A variety of assessment tools will be used to develop and assess students’ achievement of the subject intended learning outcomes. Specific assessment methods/tasks % weighting Intended subject learning outcomes to be assessed a b c d e Continuous Assessment* 50 Test 20 9 9 9 9 9 Individual assignment 15 9 9 9 9 9 Group assignment 15 9 9 9 9 Final Examination 50 9 9 9 9 Total 100 9 *Continuous assessment items and/or weighting may be adjusted by the subject team subject to the approval of the College Programme Committee. To pass this subject, students are required to obtain Grade D or above in both the Continuous Assessment and Final Examination. Student Study Class contact Hours 2 June 2015 Effort Expected Lecture 26 Tutorial 9 Laboratory 4 Other student study effort Self-study 52 Continuous Assessment 39 Total student study effort Reading List and References 130 Recommended Textbook Becker W.M., Kleinsmith, L.J. & Hardin, J. (2012). The World of the Cell. (8th ed.), Pearson/Benjamin/Cummings Int. Ed. References Alberts, B. et al. (2010). Essential Cell Biology. (3rd ed.), Garland. 3