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BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FOUR PAGES. NAME POSITION TITLE Bin Chen Associate Professor eRA COMMONS USER NAME (credential, e.g., agency login) CHENBIN EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) Beijing University, China Beijing University, China BS MS 05/1991 05/1994 State University of New York at Stony Brook PhD 2000 postdoc 2006 Stanford University Cell Biology and Genetics Cell Biology Cellular and Molecular Pharmacology Neuroscience A. Personal Statement B. Positions and Honors Positions and Employment 2000-2006 2006-2012 2012- Post-doctoral fellow, Department of Biological Sciences, Stanford University, Stanford, CA. Advisor: Dr. Susan McConnell Assistant Professor, Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, CA. Associate Professor, Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, CA. Other Experience and Professional Memberships 20002010- Life-time member, Genetics Society of America Member, Society for Neuroscience Honors 1996 1998 1998-1999 2000 20002001-2004 Vander Kloot Award for Excellence in Teaching, SUNY at Stony Brook Vander Kloot Award for Excellence in Research, SUNY at Stony Brook Institutional Predoctoral Fellowship, SUNY at Stony Brook Larry Sandler Award, Genetics Society of America Life-time Membership from Genetics Society of America NRSA, NINDS C. Selected Peer-reviewed Publications 1. Roberts, J.M., Edmondson, C., Wirth, B., Sanford, J., and Chen, B. Splicing factor SFRS10 is required for neural progenitor survival. (2013) J. Comparative Neurology. Accepted. 2. Betancourt J., Katzman S., and Chen B. Nuclear Factor One regulates neural stem cell differentiation and axonal projection of corticofugal neurons. (2013) J. Comparative Neurology. In Press (Available Online). 3. Kmet, M., Guo, C., Edmundson, C., and Chen, B. Directed differentiation of human embryonic stem cells into corticofugal neurons uncovers heterogeneous Fezf2-expressing subpopulations. (2013) PLOS One. In Press. 4. Kumamoto T, Toma K, Gunadi, McKenna WL, Kasukawa T, Katzman S, Chen B, Hanashima C. Foxg1 Coordinates the Switch from Nonradially to Radially Migrating Glutamatergic Subtypes in the Neocortex through Spatiotemporal Repression. (2013) Cell Rep. 3(3):931-45. PMID: 23523356 5. McKenna, W.L., Betancourt, J., Larkin, K.A., Abrams, B., Guo, C., Rubenstein, L.R.R., and Chen, B. Tbr1 and Fezf2 regulate alternate corticofugal neuronal identities during neocortical development. (2011) J. Neuroscience. 31(2):549-64. PMCID: 21228164. 6. Eckler, M.J., McKenna, W.L., Taghvaei, S., McConnell, S.K., and Chen, B. Fezf1 and Fezf2 are required for olfactory development and sensory neuron identity. (2011) J. Comparative Neurology. 519 (10): 182946. PMCID: 21452247. 7. Leone, D.P., Srinivasan, K., Chen, B., Alcamo, E., McConnell, S.K. The determination of projection neuron identity in the developing cerebral cortex. (2008) Curr Opin Neurobiol. 18(1):28-35. PMCID: 18508260 8. *Chen, B., Wang, S.S., Hattox, A.M., Rayburn, H., Nelson, S.B., McConnell, S.K. The Fezf2-Ctip2 genetic pathway regulates the fate choice of subcortical projection neurons in the developing cerebral cortex. (2008) Proc Natl Acad Sci U S A. 105(32):11382-7. PMCID: 18678899 9. Chen, B., Schaevitz, L. R., and McConnell, S. K. Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex. (2005) Proc. Natl. Acad. Sci. USA 102:1718417189. PMCID: 16284245 * indicates corresponding author. 10. Friedel, R.H., Plump, A., Lu, X., Spilker, K., Jolicoeur, C., Wong, K., Venkatesh, T.R., Yaron, A., Hynes, M., Chen, B., Okada, A., McConnell, S.K., Rayburn, H., Tessier-Lavigne, M. Gene targeting using a promoterless gene trap vector ("targeted trapping") is an efficient method to mutate a large fraction of genes. (2005) Proc Natl Acad Sci U S A. 2005 Sep13; 102(37):13188-93. PMCID: 16129827 11. Chen, B., Harms, E., Chu, T., Henrion, G., and Strickland, S. Completion of meiosis in Drosophila oocytes requires translational control by Grauzone, a new zinc finger protein. (2000) Development 127: 1243-1251. PMCID: 10683177 12. Chen, B., Chu, T., Harms, E., Gergen, J. P., and Strickland, S. Mapping of Drosophila mutations using site-specific male recombinations. (1998) Genetics 149: 157-163. PMCID: 9584093 Manuscript Submitted Recently 1. Guo, C., Eckler, M.J., McKenna, W.L., McKinsey, G.L., Rubenstein, J.L.R., and Chen, B. Fezf2 expression identifies a multipotent progenitor for neocortical projection neurons, astrocytes and oligodendrocytes. (2013) Neuron, in revision. 2. Eckler, M.J., Larkin, K.A., McKenna, W.L., Hirata, T., Nakazawa, M., Aizawa, S., Katzman, S., Guo, C., Roque, R., Visel, A., Rubenstein, J.L.R., Hibi, M., and Chen, B. Multiple conserved regulatory domains promote Fezf2 expression in the developing cerebral cortex. (2013) Proc Natl Acad Sci U S A. in revision. 3. Qiu, H., Lee, S., Shang, Y., Wang, W-Y., Au, K.F., Kamiya, S., Barmada, S.J., Finkbeiner, S., Lui, H., Carlton, C.E., Tang, A.A., Oldham, M.C., Wang, H., Shorter, J., Filiano, A.J., Roberson, E.D., Tourtellotte, W.G., Chen, B., Tsai, L-H., Huang, E.J. FALS mutation FUS-R521C causes profound dendritic and synaptic phenotype due to transcription and splicing defects. (2013) Nature Neuroscience, in revision. D. Research Support Ongoing Research Support National institute of Mental Health (1R01MH094589-01) 7/1/11-3/31/16 Transcriptional regulation of neuronal identity and connectivity The goal of this grant is to determine how Fezf2 and Tbr1 regulates the identities of subcerebral and corticothalamic neurons, respectively. California Institute of Regenerative Medicine (RN1-00530) Mechanisms of cell fate specification in the mammalian brain The goal of this grant is to identify transcription factor “code” for cortical projection neurons. 3/1/08-2/28/13 Completed Research Support California institute of Regenerative Medicine (RS1-00170) Differentiate human embryonic stem cells into corticospinal motor neurons 8/1/07-7/31/10 The goal of this grant is to design a strategy to differentiate human embryonic stem cells into corticospinal motor neurons, and to test their functions in vivo using cell transplant experiments. March of Dimes Foundation Basil O’connor Young Investigator Award 2/1/08-1/31/10 Understanding the function of Fezf1 and Fezf2 in brain development The goal of this grant is to understand the function of Fezf1 and Fezf2 in early brain patterning.