Download biographical sketch - Pittsburgh Center for Pain Research

BIOGRAPHICAL SKETCH
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NAME
POSITION TITLE
Michael S. Gold, PhD
Professor
eRA COMMONS USER NAME
msg001
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
DEGREE
(if applicable)
YEAR(s)
University of California at Berkeley, Berkeley, CA
University of California at Los Angeles, L A, CA
University of California at San Francisco, S F, CA
University of California at Los Angeles, L A, CA
BA
PhD
(Post-doc)
(Post-doc)
05/1987
06/1994
1994-1995
1996-1997
FIELD OF STUDY
Psychology
Neuroscience
Neuroscience
Neuroscience
A. Personal Statement
Pain continues to be a major health problem with tremendous financial, social and psychological costs.
Conservative estimates put the cost of pain to the US economy well into the hundreds of billions of dollars per
year as a result of associated medical expenses and lost wages with a significant minority of Americans
suffering from persistent or recurrent pain syndromes throughout the most productive years of their lives. Just
one pain syndrome, migraine headache, directly impacts 20% of the adult population. Yet, there remain few if
any effective therapies devoid of serious side effects that are currently available to treat pain, particularly
persistent or recurrent pain associated with syndromes.
The clinical features of a number of pain syndromes serve as the organizing focus of research in the Gold
laboratory. These observations include the following: 1) many pain syndromes are unique to a particular part of
the body such as the head in migraine, the temporomandibular joint in temporomandibular disorder (TMD), or
the colon in inflammatory bowel disease (IBD); 2) many pain syndromes such as migraine, TMD and IBD occur
with a greater prevalence, severity and/or duration in women than in men; 3) many pain syndromes are
associated with changes in the excitability of primary afferent neurons; 4) there are time dependent changes in
the mechanisms underlying pain syndromes; and 5) the type of injury, (i.e., inflammation or nerve injury), are
differentially sensitive to therapeutic interventions. These observations led to specific hypotheses that are
tested in ongoing studies in the Gold laboratory. These include 1) characterizing the mechanisms underlying
inflammation-induced changes in the evoked Ca2+ transients in sensory neurons, 2) characterizing the
mechanisms underlying the inflammatory mediator-induced sensitization of dural afferents, 3) characterizing
the influence of estrogen on the excitability of spinal and trigeminal ganglion neurons, 4) characterizing the
mechanisms underlying the link between stress and migraine, 5) characterizing the role of changes in inhibitory
receptors, in particular GABA, in injury-induced increases in sensitivity, and 6) identification of ways to
maximize the therapeutic utility of local anesthetics. The ultimate goal of these studies is to identify novel
targets for the development of therapeutic interventions for the treatment of pain.
B. Positions and Honors
Employment Experience:
Department of Oral and Maxillofacial Surgery
9/94-12/95
University of California, San Francisco, San Francisco, CA
Post-Doctoral Fellow in the laboratory of Jon. D. Levine, M.D., Ph. D.
Departments of Anesthesiology and Physiology
1/96-2/97
University of California, Los Angeles, Los Angeles, CA
Post-Doctoral Fellow in the laboratories of Drs. F. Bezanilla and A-M. Correa.
Department of Oral & Craniofacial Biological Sciences
University of Maryland at Baltimore, Baltimore, MD
Research Assistant Professor
1/98 - 7/98
Department of Oral & Craniofacial Biological Sciences
University of Maryland at Baltimore, Baltimore, MD
Assistant Professor
7/98 – 5/03
Department of Biomedical Sciences
University of Maryland at Baltimore, Baltimore, MD
Associate Professor
5/03 – 9/06
Department of Medicine Division of Gastroenterology
University of Pittsburgh School of Medicine, Pittsburgh, PA
Visiting Associate Professor
10/06 – 7/08
Department of Anesthesiology
University of Pittsburgh School of Medicine, Pittsburgh, PA
Associate Professor
8/08 – 12/10
Department of Anesthesiology
University of Pittsburgh School of Medicine, Pittsburgh, PA
Professor
1/11 –
Honors and Awards:
NIH Postdoctoral Fellowship in Neurology
Bank of America/Giannini Foundation Scholarship
American Pain Society's Early Career Achievement Award
Associate Editor for the journal Pain
Regular member of NIH Study Section NST-2
Associate Editor for Brain Research
Director at Large, American Pain Society
Editorial Board for the Journal of Pain
Faculty of 1000 in Medicine
Associate Editor for the Journal of Neuroscience
Regular member of NIH Study Section SCS
Reviewing Editor for the Journal of Neuroscience
9/94-7/97
8/97-12/97
4/01
2000 – 2009
2005 – 2009
2006 – 2010
2006 – 2007
2007 – present
2008 – present
2008 – 2009
2009 – 2011
2009 – present
C. Publications: 15 from a total of 87 journal articles, reviews and book chapters
Gold MS, Reichling DB, Shuster MJ and Levine JD (1996) Hyperalgesic agents increase a TTX-resistant Na+
current in nociceptors. Proc. Nat’l. Acad. Sci. (USA), 93 (3): 1108-1112 (PMCID: PMC40039)
Gold MS, Levine JD and Correa AM (1998) Modulation of TTX-R INa by PKC and PKA and their role in PGE2induced sensitization of rat sensory neurons in vitro. J. Neurosci. 18(24): 10345-10355 (PMID: 9852572)
Gold MS, and Thut PD (2001) Lithium increases potency of lidocaine-induced block of voltage-gated Na(+)
currents in rat sensory neurons in vitro. J Pharmacol Exp Ther 299:705-711.
Gold MS, Weinreich D, Kim S-K, Wang R, Porreca F and Lai J (2003) Redistribution of TTX-Resistant Sodium
Channels Mediates Neuopathic Pain. J. Neurosci. 23 (1): 158-166 (PMID: 12514212)
Harriott AM, and Gold MS (2008) Serotonin type 1D receptors (5HT1DR) are differentially distributed in nerve
fibers innervating craniofacial tissues. Cephelalgia 28(9): 933-944 (PMCID: PMC2682350)
Hermanstyne TO, Markowitz K, and Gold MS, (2008) Mechanotransducers in rat pulpal afferents. J Dent Res.
87(9): 834-838 (PMCID: PMC2577312)
Warren C, Mok L, Gordon S, Fouad AF, and Gold MS (2008) Quantification of neural protein in extirpated
tooth pulp. J Endo 34 (1): 7-10 (PMCID: PMC2176084)
Harriott AM, and Gold MS. (2009) Electrophysiological properties of dural afferents in the absence and
presence of inflammatory mediators. J Neurophysiol 101(6): 3126-3134 (PMCID: PMC2694126)
Zhang X-L., Mok L, Katz, EJ, and Gold MS, (2010) BKCa currents are enriched in a subpopulation of adult rat
cutaneous dorsal root ganglion neurons. Eur. J. Neurosci. 31(3): 450-462 (PMCID: PMC2843514)
Vaughn (Harriott) AM, and Gold MS (2010) Ionic mechanisms underlying inflammatory mediator-induced
sensitization of dural afferents J Neurosci 30(23): 7878-7888 (PMCID: PMC2900838)
Lu S-G, Zhang X-L, Luo ZD, and Gold MS (2010) Persistent Inflammation Alters the Density and Distribution
of Voltage-Activated Calcium Channels in Subpopulations of Rat Cutaneous DRG neurons. Pain 151(3):
633-643 (PMCID: PMC2978671)
Boegel K Gyulai FE Moore K and Gold MS (2011) Deleterious impact of a GABAA receptor preferring general
anesthetic when used in the presence of persistent inflammation. Anesthesiology 115(4): 782-90
(PMCID:PMC3179577)
Scheff, N, and Gold, MS, (2011) Sex Difference in the Inflammatory Mediator-Induced Sensitization of Dural
Afferents. J Neurophysiol. 106 (4): 1662-8 (PMCID:PMC3191837)
Lee KY, Charbonnet M, and Gold MS, (2012) Upregulation of high affinity GABAA receptors in cultured rat
dorsal root ganglion neurons. Neuroscience 208: 133-42 (PMCID:PMC3311786)
Harriott AM, Scheff N, Gold MS (In Press) The complex actions of sumatriptan on rat dural afferents
(Cephalagia)
D. Research Support.
Research Support: Active and Completed
1R01DE018252Mechanisms of Tooth Pain
PI
4/01/09 –
NIH/NIDCR
02A2
2.4 mo cal.
3/31/14
(Gold)
(349,658)
The major goal of this project is to identify mechanisms mediating ongoing pain and sensitivity associated with
inflammation of the tooth pulp.
PI
4/01/09 –
NIH/NINDS
2.4 mo cal.
3/31/13
NCE
The major goal of this project is to identify mechanisms underlying the inflammation-induced shift in spinal GABA-A
receptor circuitry.
1R01NS06301001A1
Inflammation-induced Changes in
Spinal GABA-A Receptor Signaling
Enhancing Post-Traumatic Pain
Co-PI
7/1/10 –
CDMRP
Relief with Alternative Perineural
0.6 mo cal.
6/30/13
(DOD)
Drugs
(37,392)
The major goal of this project is to identify drug combinations for use in perineural nerve blocks that will both increase the
duration of nerve block as well as provide modality specificity to the nerve block.
OR090012P1
Co-PI
11/1/10 –
NIH
1.2 mo cal.
10/31/15
(37,900)
To better define the functional consequences of Artn signaling and test the role of TRPV1 and nAChRs in GFRα3 afferent
sensitization.
5R01NS033730
(Albers)
Effects of artemin on nociceptors
Co-PI
09/1/11 –
NIH
0.6 mo cal.
08/31/16
(21,117)
To develop HSV vectors that enable the expression of therapeutic targets is specific subpopulations of sensory neurons.
1R01NS06498801A2
HSV-GlyR silencing of nociceptive
afferents
Research Award
Calcium activated chloride
channels as a novel target for the
treatment of migraine
PI
0.6 mo cal.
(50,000)
01/1/12 –
12/31/12
Migraine
Research
Foundation
To identify the chloride channel underlying the actions of inflammatory mediators on dural afferents.
Research
Contract
Human DRG Electrophysiology
PI
2.4 mo cal.
(300,000)
01/1/12 –
12/31/12
Eli Lilly
To characterize the biophysical and pharmacological properties of voltage-gated Na+ currents in human dorsal root
ganglion neurons.
COMPLETED 03/11
CTSI P4R (PI Gold, M)
Source CTSI – Virginia Kaufman Fund
Title of Project Identifying the Link Between Stress and Migraine Pain
The major goal of this project is to determine the impact of chronic stress on the impact of sympathetic post-ganglionic
neuron activity on transmitter release, mast cell degranulation, vascular permeability and tone, and afferent activity.
COMPLETED 03/11
3R01DE018252-01A2S1 (PI Gold, M)
Source NIH/NIDCR
Title of Project Mechanisms of Tooth Pain
This is an equipment supplement to the parent grant 1R01DE018252-02A2.
COMPLETED 05/09
1 RO1 NS044992-04 (PI Gold, M)
Source NIH/NINDS
Title of Project Inflammation-Induced Plasticity in Sensory Neurons
The major goals of this project were to understand the role of CaK channels in nociceptor excitability and
inflammation-induced changes in nociceptor excitability.
OVERLAP: There is no scientific overlap between projects.