Download 6. Eckler, MJ, McKenna, WL, Taghvaei, S., McConnell, SK, and

BIOGRAPHICAL SKETCH
Provide the following information for the Senior/key personnel and other significant contributors.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
Bin Chen
Associate Professor
eRA COMMONS USER NAME (credential, e.g., agency login)
CHENBIN
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and
residency training if applicable.)
DEGREE
INSTITUTION AND LOCATION
MM/YY
FIELD OF STUDY
(if applicable)
Beijing University, China
Beijing University, China
BS
MS
05/1991
05/1994
State University of New York at Stony Brook
PhD
2000
postdoc
2006
Stanford University
Cell Biology and Genetics
Cell Biology
Cellular and Molecular
Pharmacology
Neuroscience
A. Personal Statement
B. Positions and Honors
Positions and Employment
2000-2006
2006-2012
2012-
Post-doctoral fellow, Department of Biological Sciences, Stanford University, Stanford, CA.
Advisor: Dr. Susan McConnell
Assistant Professor, Department of Molecular, Cell, and Developmental Biology, University of
California, Santa Cruz, CA.
Associate Professor, Department of Molecular, Cell, and Developmental Biology, University of
California, Santa Cruz, CA.
Other Experience and Professional Memberships
20002010-
Life-time member, Genetics Society of America
Member, Society for Neuroscience
Honors
1996
1998
1998-1999
2000
20002001-2004
Vander Kloot Award for Excellence in Teaching, SUNY at Stony Brook
Vander Kloot Award for Excellence in Research, SUNY at Stony Brook
Institutional Predoctoral Fellowship, SUNY at Stony Brook
Larry Sandler Award, Genetics Society of America
Life-time Membership from Genetics Society of America
NRSA, NINDS
C. Selected Peer-reviewed Publications
1. Roberts, J.M., Edmondson, C., Wirth, B., Sanford, J., and Chen, B. Splicing factor SFRS10 is required for
neural progenitor survival. (2013) J. Comparative Neurology. Accepted.
2. Betancourt J., Katzman S., and Chen B. Nuclear Factor One regulates neural stem cell differentiation and
axonal projection of corticofugal neurons. (2013) J. Comparative Neurology. In Press (Available Online).
3. Kmet, M., Guo, C., Edmundson, C., and Chen, B. Directed differentiation of human embryonic stem cells
into corticofugal neurons uncovers heterogeneous Fezf2-expressing subpopulations. (2013) PLOS One. In
Press.
4. Kumamoto T, Toma K, Gunadi, McKenna WL, Kasukawa T, Katzman S, Chen B, Hanashima C. Foxg1
Coordinates the Switch from Nonradially to Radially Migrating Glutamatergic Subtypes in the Neocortex
through Spatiotemporal Repression. (2013) Cell Rep. 3(3):931-45. PMID: 23523356
5. McKenna, W.L., Betancourt, J., Larkin, K.A., Abrams, B., Guo, C., Rubenstein, L.R.R., and Chen, B. Tbr1
and Fezf2 regulate alternate corticofugal neuronal identities during neocortical development. (2011) J.
Neuroscience. 31(2):549-64. PMCID: 21228164.
6. Eckler, M.J., McKenna, W.L., Taghvaei, S., McConnell, S.K., and Chen, B. Fezf1 and Fezf2 are required
for olfactory development and sensory neuron identity. (2011) J. Comparative Neurology. 519 (10): 182946. PMCID: 21452247.
7. Leone, D.P., Srinivasan, K., Chen, B., Alcamo, E., McConnell, S.K. The determination of projection neuron
identity in the developing cerebral cortex. (2008) Curr Opin Neurobiol. 18(1):28-35. PMCID: 18508260
8. *Chen, B., Wang, S.S., Hattox, A.M., Rayburn, H., Nelson, S.B., McConnell, S.K. The Fezf2-Ctip2 genetic
pathway regulates the fate choice of subcortical projection neurons in the developing cerebral cortex.
(2008) Proc Natl Acad Sci U S A. 105(32):11382-7. PMCID: 18678899
9. Chen, B., Schaevitz, L. R., and McConnell, S. K. Fezl regulates the differentiation and axon targeting of
layer 5 subcortical projection neurons in cerebral cortex. (2005) Proc. Natl. Acad. Sci. USA 102:1718417189. PMCID: 16284245
* indicates corresponding author.
10. Friedel, R.H., Plump, A., Lu, X., Spilker, K., Jolicoeur, C., Wong, K., Venkatesh, T.R., Yaron, A., Hynes, M.,
Chen, B., Okada, A., McConnell, S.K., Rayburn, H., Tessier-Lavigne, M. Gene targeting using a
promoterless gene trap vector ("targeted trapping") is an efficient method to mutate a large fraction of
genes. (2005) Proc Natl Acad Sci U S A. 2005 Sep13; 102(37):13188-93. PMCID: 16129827
11. Chen, B., Harms, E., Chu, T., Henrion, G., and Strickland, S. Completion of meiosis in Drosophila
oocytes requires translational control by Grauzone, a new zinc finger protein. (2000) Development 127:
1243-1251. PMCID: 10683177
12. Chen, B., Chu, T., Harms, E., Gergen, J. P., and Strickland, S. Mapping of Drosophila mutations using
site-specific male recombinations. (1998) Genetics 149: 157-163. PMCID: 9584093
Manuscript Submitted Recently
1. Guo, C., Eckler, M.J., McKenna, W.L., McKinsey, G.L., Rubenstein, J.L.R., and Chen, B. Fezf2 expression
identifies a multipotent progenitor for neocortical projection neurons, astrocytes and oligodendrocytes.
(2013) Neuron, in revision.
2. Eckler, M.J., Larkin, K.A., McKenna, W.L., Hirata, T., Nakazawa, M., Aizawa, S., Katzman, S., Guo, C.,
Roque, R., Visel, A., Rubenstein, J.L.R., Hibi, M., and Chen, B. Multiple conserved regulatory domains
promote Fezf2 expression in the developing cerebral cortex. (2013) Proc Natl Acad Sci U S A. in revision.
3. Qiu, H., Lee, S., Shang, Y., Wang, W-Y., Au, K.F., Kamiya, S., Barmada, S.J., Finkbeiner, S., Lui, H.,
Carlton, C.E., Tang, A.A., Oldham, M.C., Wang, H., Shorter, J., Filiano, A.J., Roberson, E.D., Tourtellotte,
W.G., Chen, B., Tsai, L-H., Huang, E.J. FALS mutation FUS-R521C causes profound dendritic and
synaptic phenotype due to transcription and splicing defects. (2013) Nature Neuroscience, in revision.
D. Research Support
Ongoing Research Support
National institute of Mental Health (1R01MH094589-01)
7/1/11-3/31/16
Transcriptional regulation of neuronal identity and connectivity
The goal of this grant is to determine how Fezf2 and Tbr1 regulates the identities of subcerebral and
corticothalamic neurons, respectively.
California Institute of Regenerative Medicine (RN1-00530)
Mechanisms of cell fate specification in the mammalian brain
The goal of this grant is to identify transcription factor “code” for cortical projection neurons.
3/1/08-2/28/13
Completed Research Support
California institute of Regenerative Medicine (RS1-00170)
Differentiate human embryonic stem cells into corticospinal motor neurons
8/1/07-7/31/10
The goal of this grant is to design a strategy to differentiate human embryonic stem cells into corticospinal
motor neurons, and to test their functions in vivo using cell transplant experiments.
March of Dimes Foundation Basil O’connor Young Investigator Award
2/1/08-1/31/10
Understanding the function of Fezf1 and Fezf2 in brain development
The goal of this grant is to understand the function of Fezf1 and Fezf2 in early brain patterning.