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Central Dogma of Molecular Biology Genetic information flows in one direction – from DNA to RNA to proteins. Bellringer What do these words mean to you? Write a short 2 word definition for each • • • • • • • 1. Mutation 2. Duplication 3. Deletion 4. Insertion 5. Translocation 6. Inversion 7. Substitution KEY CONCEPT Mutations are changes in DNA that can affect phenotype What are Mutations? (video link) Mutations are changes to DNA that may be • Harmful • Helpful • Have no effect. When Mutations Occur 1. Errors can occur during: DNA Replication Protein Synthesis Meiosis . Causes of Mutations 2. Mutagens – Environmental factors that cause changes in DNA Examples: - Radiation - Chemicals in environment The effect mutations have on an organism’s physical characteristics depends on: 1. The number and type of genes involved 2. Type of cell the mutation occurs in – somatic or sex Mutations in Somatic Cells: • Affect only the organism they occur in. • Cannot be passed to offspring. Mutations in Sex (Germ) cells: • May be passed to offspring Two Categories of Mutations: 1.Single Gene – affects one gene – usually caused by an error in DNA replication 2. Chromosomal – affects chromosomes – usually error in meiosis . Usually more harmful since many genes are affected. Types of Chromosomal Mutations • • • • • Translocation Duplication Nondisjunction Deletion Inversion • TRANSLOCATION (“transfer location”) • Piece of one chromosome breaks off and moves to a nonhomologous chromosomes. • DUPLICATION. • Two or more copies of the same gene on a chromosome . • NONDISJUNCTION • Homologous chromosomes don’t separate in Anaphase I • Sister chromatids don’t separate in Anaphase II • Deletion • Section of chromosome containing one or more genes is removed • Inversion • Section of a chromosome flips its position Single Gene Mutations • Usually occur in DNA replication • Affect one gene and the protein made from it Types of Gene Mutations Frameshift The insertion or deletion of a number of bases that is not a multiple of 3. Alters the reading frame. Deletion One or more bases are deleted. This alters the reading frame Insertion One or more bases added to sequence.. Point A single base change in DNA sequence. One base is substituted for another Types of point mutations are: nonsense, missense, or silent. Nonsense A change in the DNA sequence that results in the coding for a stop codon instead of an amino acid. Full protein not made. Missense Change in DNA sequence that results in a codon that requests the wrong amino acid. This type of mutation can be harmful, others harmless Silent A change in the DNA sequence that does not change the protein sequence. Example Frameshift Mutation • Caused by adding or removing 1-2 bases • Changes the reading frame • . Type of Frameshift Mutation .Deletion - one or more bases are deleted; shifts the reading frame Type of Frameshift Mutation Insertion - one or more bases are added; shifts the reading frame Point Mutations • One nucleotide is replaced by another. mutated base Types of Point Mutations Determined by their outcomes Nonsense point mutation • Change codes for a STOP codon • Full protein not made • “NO” STOP Missense Point Mutation * Codes for wrong amino acid * May be harmful or beneficial – depends… Silent point mutation Does not result in a different amino acid or protein made. DNA changes but its expression (phenotype) does not. Results of mutations may be: • Harmful – needed protein isn’t made • Have NO EFFECT – are not harmful or helpful • Beneficial are favored by natural selection – rarely occurs Mutations increase genetic variety Natural selection favors mutations that provide survival advantage. Laron Syndrome mutation that causes dwarfism also protects against cancer and diabetes. • ABC Evening News - Laron Syndrome • Mutations in body cells do not affect offspring. • Only Mutations in sex cells affect offspring. • Natural selection favors mutations that provide an adaptation that has survival advantage