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Grade level 2013-14 Guide: Gene Regulation, Mutations, Karyotypes *Key Vocabulary-Gene Regulation IDK Know it! Term Gene Chromosome DNA Hox Gene Transcription Translation Protein and Amino Acid Express (expression) Differentiate (differentiation) Regulate (Regulation) codon *Key Vocabulary- Mutations IDK Know it! Term Mutation Gene Mutation Point Mutation Substitution Insertion Deletion Nitrogenous Base or Nucleotide Silent Mutation Chromosomal Mutation Translocation Inversion Duplication Amino Acid Sequence *Key Vocabulary- Karyotypes IDK Know it! Term Karyotypes Autosome Sex Chromosome Somatic Cell Gamete Zygote Fertilization Monosomy Trisomy Nondisjuction *Key Vocabulary- Meiosis IDK Know it! Term Sexual Reproduction mitosis Meiosis I Meiosis II Interphase Prophase I and II Metaphase I and II Anaphase I and II Telophase I and II Cytokinesis Gamete Zygote Spindle Fibers and Centrioles Grade level 2013-14 Review Questions: Gene Regulation and Expression What is a gene? How does a gene represent information? What does it mean when a gene is “expressed”? Why is it important for genes to be expressed? Why do genes need to regulated or “turned off”? Do cells have only specific genes for their function? What are hox genes? What is differentiation? Review Questions: Mutations What is a mutation? What can cause point or gene mutations? Why is a frameshift mutation more severe or harmful than a substitution? A short segment of DNA that contains a code for a specific protein sequence The code on the DNA is a series of nitrogen bases (A,T,C,G). The order of the nitrogen bases is a code “read” by a ribosome during translation. The ribosome puts together amino acids to make a protein based on the code from the gene. An RNA polymerase transcribes the DNA gene to make an mRNA to be translated by the ribosome. Genes give the instructions for the creation of proteins. Proteins give structure and function to each cell and they control chemical reactions. Only certain genes are needed at certain times. NO, all body or somatic cells have the FULL SET of DNA. Cells only express the genes that they specifically need to do their job. Hox genes are the specific set of genes that are needed for a particular cell to do its job. Skin cells express different hox genes than nerve cells. The process that cells and systems of an organism go through where they express only certain genes (hox genes) to have a specific structure and function. All cells start off the same at fertilization but over time they “differentiate” into specializes cells, tissues, and organs.