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Relationship of integral and peripheral membrane proteins to the membrane phospholipid bilayer. Integral membrane proteins (a) have portions of their
mass embedded in the membrane that interact directly with the hydrophobic tails of the phospholipids. Other portions of these proteins are exposed on the
cytoplasmic or luminal membrane faces. The extent of exposure on each side of the membrane may vary substantially from one protein to another.
Peripheral membrane proteins (b and c) may interact with the exposed portions of integral membrane proteins and are associated with the membrane only
by virtue of these interactions. Exposed portions of integral membrane protein molecules may directly interact with each other or may be indirectly linked
together via their association with interacting peripheral membrane proteins. On the cytoplasmic face, peripheral membrane proteins may provide a link
Source: The Biogenesis of Membranes and Organelles, The Online Metabolic and Molecular Bases of Inherited Disease
between integral membrane proteins and the cellular cytoskeleton.
Citation: Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A, Gibson K, Mitchell G. The Online Metabolic and Molecular
Bases of Inherited Disease; 2014 Available at: http://mhmedical.com/ Accessed: August 03, 2017
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