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Chapter 2 - DNA MC 1. [37 marks] The image shows a DNA nucleotide. [1 mark] Which correctly identifies the parts labelled I and II? Markscheme C 2. Which model represents transcription? Markscheme A [1 mark] 3. Which sequence represents the order of events in protein synthesis? [1 mark] Markscheme B 4. What happens during glycolysis for one molecule of glucose? [1 mark] A. Two pyruvates are formed. B. There is a net gain of two NADPH + H +. C. There is a net loss of two ATP. D. Two acetyl CoA are formed. Markscheme A 5. Which type of bond is identified by the arrow? [1 mark] A. Phosphate B. Hydrogen C. Covalent D. Peptide Markscheme C 6. What is required to replicate DNA? A. Temperature of 37 °C B. Free nucleotides carrying A, C, G and T bases C. Plasmids D. Endonuclease [1 mark] Markscheme B 7. How is the information in the genetic code used? [1 mark] A. To predict the genotype of gametes B. To distinguish prokaryotic genomes from eukaryotic genomes C. To deduce phenotypes in pedigree charts D. To translate mRNA into polypeptides Markscheme D 8. What is required to replicate DNA? [1 mark] A. Temperature of 37 °C B. Free nucleotides carrying A, C, G and T bases C. Plasmids D. Endonuclease Markscheme B 9. The base sequence of a fragment of DNA is: ACC GTG CAG GAT What is the base sequence on the messenger RNA (mRNA) molecule transcribed from it? A. TGG CAC GTC CTA B. TGG CUC GTC CTU C. UGG CTC GUC CUT D. UGG CAC GUC CUA Markscheme D [1 mark] 10. What is correct for the DNA double helix? [1 mark] Markscheme D 11. A base substitution in a gene has changed a codon. Which of these consequences could result from a base substitution in a codon? I. Another amino acid will be incorporated in the protein II. A stop codon is generated III. The same protein will be synthesized A. I only B. I and II only C. I and III only D. I, II and III Markscheme D [1 mark] 12. What links the pairs of complementary bases in a DNA double helix? [1 mark] A. Covalent bonds B. Hydrogen bonds C. Ionic bonds D. Peptide bonds Markscheme B 13. Organisms can be genetically modified to produce the human blood clotting factor IX. What characteristic of the genetic code makes this possible? [1 mark] A. It is conservative. B. It is degenerate. C. It is complementary. D. It is universal Markscheme D 14. What is the relationship between enzymes and DNA? [1 mark] A. Enzymes contain the code for DNA. B. Enzymes act on DNA during translation. C. Both enzymes and DNA have similar shapes. D. The structure of enzymes is determined by DNA. Markscheme D 15. What occurs during DNA replication? A. DNA polymerase separates the two DNA strands. B. DNA molecules containing nucleotides from the original molecule are produced. C. Adenine forms a base pair with either thymine or uracil. D. New bases attach to the original sugar-phosphate backbone. Markscheme B [1 mark] 16. The diagram shows the translation of a mRNA molecule. [1 mark] A tRNA molecule with anticodon CAG carries the amino acid phenylalanine. Which codon of mRNA will the tRNA join? A. CTG B. CAG C. GTC D. GUC Markscheme D 17. What is formed during transcription? [1 mark] A. RNA strand complementary to DNA strand, formed by RNA polymerase B. DNA strand complementary to DNA strand, formed by DNA polymerase C. RNA strand complementary to RNA strand, formed by DNA polymerase D. DNA strand complementary to RNA strand, formed by RNA polymerase Markscheme A 18. What occurs during DNA replication? A. DNA polymerase separates the two DNA strands. B. DNA molecules containing nucleotides from the original molecule are produced. C. Adenine forms a base pair with either thymine or uracil. D. New bases attach to the original sugar-phosphate backbone. Markscheme B [1 mark] 19. Which of the following statements is/are correct for DNA replication? [1 mark] I. It occurs during interphase. II. It is semi-conservative. III. It is a stage in protein synthesis. A. I only B. II only C. I and II only D. I, II and III Markscheme C 20. Which of the following processes uses DNA ligase? [1 mark] A. Unwinding DNA B. Gene transfer using plasmids C. Adding primers D. Complementary base pairing Markscheme B 21. What does the structure labelled X represent? [1 mark] A. Hydrogen bond B. Phosphate C. Covalent bond D. Base Markscheme C 22. What does the structure labelled Y represent? [1 mark] A. Ribose B. Thymine C. Guanine D. Deoxyribose Markscheme B 23. Which points to the 3′ end of a strand of DNA? A. I B. II C. III D. IV Markscheme B [1 mark] 24. What type of bond does Z represent? [1 mark] A. Covalent bond B. Hydrogen bond C. Peptide bond D. Semi-conservative bond Markscheme A 25. The diagram shows part of a DNA molecule. [1 mark] What type of bond does X represent? A. Covalent bond B. Hydrogen bond C. Peptide bond D. Semi-conservative bond Markscheme A 26. What will be the sequence on the mRNA molecule that is produced when the DNA base sequence ACTGATGCC is [1 mark] transcribed? A. ACTGATGCC B. ACUGAUGCC C. TGACTACGG D. UGACUACGG Markscheme D 27. Which of the following are involved in both replication and transcription? [1 mark] A. DNA only B. DNA and RNA C. DNA and ribosomes D. DNA, RNA and ribosomes Markscheme B 28. What is a codon? A. A sequence of nucleotides on rRNA that corresponds to an amino acid B. A sequence of nucleotides on mRNA that corresponds to an amino acid C. A sequence of nucleotides on tRNA that corresponds to an amino acid D. A sequence of nucleotides on DNA that corresponds to an amino acid [1 mark] Markscheme B 29. What sequence of processes is carried out by the structure labelled X during translation? [1 mark] A. Combining with an amino acid and then binding to an anticodon B. Binding to an anticodon and then combining with an amino acid C. Binding to a codon and then combining with an amino acid D. Combining with an amino acid and then binding to a codon Markscheme D 30. The following diagram shows a short stretch of DNA. What bases are indicated by labels Y and Z? [1 mark] Markscheme B 31. Which molecules form the nucleotide marked in the diagram? [1 mark] A. phosphate, deoxyribose and nitrogenous base B. phosphorus, ribose and nitrogenous base C. phosphorus, deoxyribose and guanosine D. phosphate, ribose and guanine Markscheme A 32. Which enzyme catalyzes the elongation of the leading strand? A. RNA polymerase B. Helicase C. DNA polymerase D. Ligase Markscheme C [1 mark] 33. The table below shows the codons that determine different amino acids in protein translation. [1 mark] What is the sequence of the amino acids that is being translated from the following mRNA sequence? 5' AUGGGUGCUUAUUGGUAA 3' A. Met-Pro-Arg-Ile-Thr B. Met-Cys-Ser-Tyr-Trp C. Met-Gly-Ala-Tyr-Trp D. Met-Gly-Tyr-Ala-Thr Markscheme C 34. What principle is necessary to prevent mutation of DNA during replication? A. Base pairing is complementary. B. One gene codes for one polypeptide. C. Substrates are specific to enzymes. D. The genetic code is universal. [1 mark] Markscheme A 35. What happens during translation? A. Copying of DNA to produce DNA B. Copying of DNA to produce mRNA C. Copying of DNA to produce tRNA D. Polypeptide synthesis Markscheme D [1 mark] 36. In the model of the DNA molecule shown below, which arrows point to covalent bonds? [1 mark] A. I, II and III only B. II, III and IV only C. I, III and IV only D. I, II and IV only Markscheme D 37. On which molecule is a codon found? [1 mark] A. DNA B. mRNA C. tRNA D. rRNA Markscheme B © International Baccalaureate Organization 2017 International Baccalaureate® - Baccalauréat International® - Bachillerato Internacional® Printed for Highland High School