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Nutritional Genomics Genes, Nutrition and Chronic Eye Disease A one-hour discussion on the latest research on affecting gene expression and nutrition I. Definition of Genomics a. Nutritional Genomics b. DNA, RNA and Protein Synthesis c. Transcriptomics, Proteonomics and Metabolomics II. The New Paradigm of Nutritional Genomics a. University programs b. Research Publications c. What’s Hot in Nutrition and Gene Science d. The Two Approaches i. Reductionist Approach ii. Systems Approach III. Baby Lucy and our genes a. Who is Baby Lucy and what makes her so special b. Why our cells respond to nutritional status c. The interplay of nutrition, genes, lifestyle and health IV. Cells and Molecular Nutrition a. Why do we need antioxidants? b. Free radical formation c. Our cells and DNA expression i. Primacy of DNA ii. Primacy of the Environment V. Epigenomics a. What is Epigenomics b. How does genetic information get expressed c. How nutrition affects gene expression VI. Macular Degeneration a. The genetic influence b. Complement System influence c. Vascular Endothelial Growth Factor d. Nuclear Factor kappa B e. The Phototrop Study VII. Diabetes a. Definition b. Genetic vs. environmental influences c. Effects of statins VIII. Other genetic influences a. Glaucoma b. Binocular vision c. Autism IX. Personalized Medicine and Genetics a. Genetic testing in our future b. How much do we want to know? c. What do we learn by testing genes? d. Four principals of biomedical ethics e. Genetic Information Nondiscrimination Act (GINA) f. Tenets of Nutritional Genomics X. Where are the Bodies? a. Are nutrients harmful? b. Common misconceptions about nutrients c. What is an “adverse effect” XI. Take Home Message-Summary