Download Cloze passage 4

BIOLOGY Y12
Option – The Code Broken
CLOZE PASSAGE No 4
Gene Therapy and Mutations
Complete the following sentences using appropriate words or short phrases
a) Inherited disease causing the build-up of excess mucus in the lungs
b)
The mutation, deletion of the bases CTT causes the amino acid ………… not to be
produced in CF patients
c) This mutation is called ………………
Cystic Fibrosis
Phenylalanine
ΔF508
d) The treatment of a disease by replacing, switching or correcting faulty genes is called Gene therapy
e) Gene therapy always involves……………………… technologies
Recombinant DNA
f) In CF patients the vector used to move the gene into the lungs
A virus
g) Mutations can be either ……………………. or ………………………
Chromosomal or
gene
Jacob and Klinefelter
syndrome
h) XYY individuals are called and XXY are called
i)
Turner syndrome XO is caused by the ………………. of a sex chromosome
deletion
j)
When part of a chromosome joins onto another
translocation
k) The big fat cat ate the rat  The big bat cat ate the rat
l)
The big fat cat ate the rat  The igb atc ata tet her at
Base substitution
Deletion causing
frameshift
m) Cells that become gametes are called ……………. cells
Germ
n) These cells undergo …………….. to make gametes
meiosis
o) Mutations in germ cells or gametes may be passed onto next ………………..
generation
p) Body cells are known as ……………………. cells
somatic
q) The presence of extra sets of chromosomes is called
Polyploidy
r) This occurs more common in …………………. than in animals
plants
s) DNA segments that can move from one position to another on a chromosome
t) These elements are commonly called………………… or “…………………….”
Transposable genetic
elements
Transposons or
“jumping genes”
u) These elements were discovered by American biologist ………………….in the 1940’s Barbara McClintock
v)
Her ideas were too advanced for the time and she was not recognised until 1983
when she was awarded the …………………. prize for her work
Nobel
w) Mutations are 1 source of variation that is essential for ………………….
Evolution
x) DNA has the ability to …………………… itself
repair
y) DNA damage …………………. as we age
increases
z)
Scientist have discovered that there are approx …………. genes whose job it is to
repair damaged DNA
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