Download Yeast ING Protein Yeast Protein Human Ortholog Description of

Yeast
ING
Protein
Yeast
Protein
Human
Ortholog
Yng2
OCT1
MIPEP
Pho23
ABF2
HMGB3
YNG1
ACP1
NDUFAB1
Yng2
AFG3
AFG3L2
Yng1,
Yng2
ALD4
ALDH1B1
Yng2
ARH1
FDXR
Yng2
ATM1
ABCB7
Yng2
ATP11
N.D*
Yng2
ATP12
ATPAF2
Yng1,
Yng2
AYR1
N.D
Yng1
CBP2
N.D
Pho23
CBR1
CYB5R2
Description of Yeast gene function**
Mitochondrial intermediate peptidase, cleaves N-terminal residues
of a subset of proteins upon import, after their cleavage by
mitochondrial processing peptidase (Mas1p-Mas2p); may
contribute to mitochondrial iron homeostasis
Mitochondrial DNA-binding protein involved in mitochondrial DNA
replication and recombination, member of HMG1 DNA-binding
protein family; activity may be regulated by protein kinase A
phosphorylation
Mitochondrial matrix acyl carrier protein, involved in biosynthesis
of octanoate, which is a precursor to lipoic acid; activated by
phosphopantetheinylation catalyzed by Ppt2p
Component, with Yta12p, of the mitochondrial inner membrane mAAA protease that mediates degradation of misfolded or
unassembled proteins and is also required for correct assembly of
mitochondrial enzyme complexes. spg-7 encodes a
metalloprotease orthologous to human paraplegin, a nuclearencoded mitochondrial metalloprotease mutations in which are
associated with hereditary spastic paraplegia (spinal cord
dysfunction); based upon studies of Saccharomyces cerevisiae
SPG7, C. elegans SPG-7 is predicted to function as part of a mtAAA metalloprotease that regulates proteolytic degradation of
mitochondrial proteins and formation of multisubunit mitochondrial
protein complexes
Mitochondrial aldehyde dehydrogenase, required for growth on
ethanol and conversion of acetaldehyde to acetate;
phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+
equally as coenzymes; expression is glucose repressed
Oxidoreductase of the mitochondrial inner membrane, involved in
cytoplasmic and mitochondrial iron homeostasis and required for
activity of Fe-S cluster-containing enzymes; one of the few
mitochondrial proteins essential for viability
Mitochondrial inner membrane ATP-binding cassette (ABC)
transporter, exports mitochondrially synthesized precursors of
iron-sulfur (Fe/S) clusters to the cytosol
Molecular chaperone, required for the assembly of alpha and beta
subunits into the F1 sector of mitochondrial F1F0 ATP synthase
Conserved protein required for assembly of alpha and beta
subunits into the F1 sector of mitochondrial F1F0 ATP synthase;
mutation of human ATP12 reduces active ATP synthase levels
and is associated with the disorder ATPAF2 deficiency
NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase
found in lipid particles, ER, and mitochondrial outer membrane;
involved in phosphatidic acid biosynthesis; required for spore
germination; capable of metabolizing steroid hormones
Mitochondrial protein required for splicing of the group I intron aI5
of the COB pre-mRNA, binds to the RNA to promote splicing; also
involved in but not essential for splicing of the COB bI2 intron and
the intron in the 21S rRNA gene
Microsomal cytochrome b reductase, not essential for viability;
also detected in mitochondria; mutation in conserved NADH
binding domain of the human ortholog results in type I
methemoglobinemia
Yng2
CCE1
N.D
Yng1
CDC9
LIG1
Yng2
CYT2
N.D
Yng2
DIN7
EXO1
Yng2
DLD3
D2HGDH
Yng2,
Pho23
DOP1
DOPEY2
Yng2
ECM40
N.D
Yng2
EFR3
N.D
Yng2,
Pho23
FRE5
N.D
Yng1
FUN30
SMARCAD
1
Yng2
FZO1
MFN2
Yng2,
Pho23
GDB1
AGL
HFA1
ACACB
Pho23
HMI1
N.D
Yng2,
Pho23
HSP78
N.D
Yng2
HSP82
HSP90AB1
Mitochondrial cruciform cutting endonuclease, cleaves Holliday
junctions formed during recombination of mitochondrial DNA
DNA ligase found in the nucleus and mitochondria, an essential
enzyme that joins Okazaki fragments during DNA replication; also
acts in nucleotide excision repair, base excision repair, and
recombination. lig-1 is orthologous to the human gene LIM
HOMEOBOX PROTEIN 3 ISOFORM B, which when mutated
leads to disease.
Cytochrome c1 heme lyase, involved in maturation of cytochrome
c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c
reductase; links heme covalently to apocytochrome c1
Mitochondrial nuclease functioning in DNA repair and replication,
modulates the stability of the mitochondrial genome, induced by
exposure to mutagens, also induced during meiosis at a time
nearly coincident with commitment to recombination
D-lactate dehydrogenase, part of the retrograde regulon which
consists of genes whose expression is stimulated by damage to
mitochondria and reduced in cells grown with glutamate as the
sole nitrogen source, located in the cytoplasm
Protein of unknown function, essential for viability, involved in
establishing cellular polarity and morphogenesis; the authentic,
non-tagged protein is detected in highly purified mitochondria in
high-throughput studies
Mitochondrial ornithine acetyltransferase, catalyzes the fifth step
in arginine biosynthesis; also possesses acetylglutamate synthase
activity, regenerates acetylglutamate while forming ornithine
Non-essential protein of unknown function; exhibits synthetic
lethal genetic interactions with PHO85; the authentic, non-tagged
protein is detected in highly purified mitochondria in highthroughput studies and is phosphorylated
Putative ferric reductase with similarity to Fre2p; expression
induced by low iron levels; the authentic, non-tagged protein is
detected in highly purified mitochondria in high-throughput studies
Protein whose overexpression affects chromosome stability,
potential Cdc28p substrate; homolog of Snf2p; the authentic, nontagged protein is detected in highly purified mitochondria in highthroughput studies
Mitochondrial integral membrane protein involved in mitochondrial
fusion and maintenance of the mitochondrial genome; contains Nterminal GTPase domain
Glycogen debranching enzyme containing glucanotranferase and
alpha-1,6-amyloglucosidase activities, required for glycogen
degradation; phosphorylated in mitochondria
Mitochondrial acetyl-coenzyme A carboxylase, catalyzes the
production of malonyl-CoA in mitochondrial fatty acid biosynthesis
Mitochondrial inner membrane localized ATP-dependent DNA
helicase, required for the maintenance of the mitochondrial
genome; not required for mitochondrial transcription; has
homology to E. coli helicase uvrD
Oligomeric mitochondrial matrix chaperone that cooperates with
Ssc1p in mitochondrial thermotolerance after heat shock; prevents
the aggregation of misfolded matrix proteins; component of the
mitochondrial proteolysis system
Hsp90 chaperone required for pheromone signaling and negative
regulation of Hsf1p; docks with Tom70p for mitochondrial
Yng1
HTS1
hisRS
(HARS)
Yng2
ILV5
N.D
Yng2
IML2
TTC39C
Pho23
INH1
N.D
Yng2
ISA2
ISCA2
Yng2
ISU2
ISCU
Pho23
MAS1
PMPCB
Yng2
MAS2
PMPCA
Yng2
MCR1
CYB5R2
Yng1,
Yng2
MDM20
C12orf30
Yng1
MEF1
GFM1
Yng1
MIS1
MTHFD1
Yng2
MRF1
MTRF1L
Pho23
MRP2
MRPS14
Pho23
MRP20
N.D
preprotein delivery; promotes telomerase DNA binding and
nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
Cytoplasmic and mitochondrial histidine tRNA synthetase;
encoded by a single nuclear gene that specifies two messages;
efficient mitochondrial localization requires both a presequence
and an amino-terminal sequence
Acetohydroxyacid reductoisomerase, mitochondrial protein
involved in branched-chain amino acid biosynthesis, also required
for maintenance of wild-type mitochondrial DNA and found in
mitochondrial nucleoids
Protein of unknown function; the authentic, non-tagged protein is
detected in highly purified mitochondria in high-throughput studies
(ATPIF1)Protein that inhibits ATP hydrolysis by the F1F0-ATP
synthase, inhibitory function is enhanced by stabilizing proteins
Stf1p and Stf2p; has similarity to Stf1p and both Inh1p and Stf1p
exhibit the potential to form coiled-coil structures
Protein required for maturation of mitochondrial and cytosolic Fe/S
proteins, localizes to the mitochondrial intermembrane space,
overexpression of ISA2 suppresses grx5 mutations
Conserved protein of the mitochondrial matrix, required for
synthesis of mitochondrial and cytosolic iron-sulfur proteins,
performs a scaffolding function in mitochondria during Fe/S cluster
assembly; isu1 isu2 double mutant is inviable
Smaller subunit of the mitochondrial processing protease (MPP),
essential processing enzyme that cleaves the N-terminal targeting
sequences from mitochondrially imported proteins
Larger subunit of the mitochondrial processing protease (MPP),
essential processing enzyme that cleaves the N-terminal targeting
sequences from mitochondrially imported proteins
Mitochondrial NADH-cytochrome b5 reductase, involved in
ergosterol biosynthesis
Non-catalytic subunit of the NatB N-terminal acetyltransferase,
which catalyzes N-acetylation of proteins with specific N-terminal
sequences; involved in mitochondrial inheritance and actin
assembly
Mitochondrial elongation factor involved in translational
elongation. F29C12.4 encodes the C. elegans ortholog of
mitochondrial translation elongation factor G1 (EFG1), a GTPbinding protein essential for the elongation phase of protein
synthesis
Mitochondrial C1-tetrahydrofolate synthase, involved in
interconversion between different oxidation states of
tetrahydrofolate (THF); provides activities of formyl-THF
synthetase, methenyl-THF cyclohydrolase, and methylene-THF
dehydrogenase
Mitochondrial translation release factor, involved in stop codon
recognition and hydrolysis of the peptidyl-tRNA bond during
mitochondrial translation; lack of MRF1 causes mitochondrial
genome instability
Mitochondrial ribosomal protein of the small subunit
Protein involved in homologous recombination in mitochondria
and in transcription regulation in nucleus; binds to activation
domains of acidic activators; required for recombinationdependent mtDNA partitioning
Yng2
MRP21
N.D
Mitochondrial ribosomal protein of the large subunit; MRP21
exhibits genetic interactions with mutations in the COX2 and
COX3 mRNA 5'-untranslated leader sequences
Yng2
MRP7
N.D
Mitochondrial ribosomal protein of the large subunit
Yng2
MRPL11
N.D
Mitochondrial ribosomal protein of the large subunit
YNG1
MRPL17
MRPL46
Mitochondrial ribosomal protein of the large subunit
Yng2
MRPL27
N.D
Mitochondrial ribosomal protein of the large subunit
Pho23
MRPL28
N.D
Mitochondrial ribosomal protein of the large subunit
Yng2
MRPL9
MRPL3
Pho23
Yng2,
Yng1
Yng2,
Pho23
MRPS18
N.D
Mitochondrial ribosomal protein of the large subunit
Mitochondrial ribosomal protein of the small subunit; essential for
viability, unlike most other mitoribosomal proteins
MRPS28
N.D
Mitochondrial ribosomal protein of the small subunit
MRPS5
MRPS5
Pho23
MSD1
DARS2
Yng2
MSH1
N.D
Pho23
MSP1
AFDC1
Yng2
MSS116
DDX18
Yng2
MSS2
N.D
Yng2
MTF2
N.D
Mitochondrial ribosomal protein of the small subunit
Mitochondrial aspartyl-tRNA synthetase, required for acylation of
aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and
lysyl-tRNA synthetases contain regions with high sequence
similarity, suggesting a common ancestral gene
DNA-binding protein of the mitochondria involved in repair of
mitochondrial DNA, has ATPase activity and binds to DNA
mismatches; has homology to E. coli MutS; transcription is
induced during meiosis
Mitochondrial protein involved in sorting of proteins in the
mitochondria; putative membrane-spanning ATPase
DEAD-box protein required for efficient splicing of mitochondrial
Group I and II introns; non-polar RNA helicase that also facilities
strand annealing
Peripherally bound inner membrane protein of the mitochondrial
matrix involved in membrane insertion of C-terminus of Cox2p,
interacts genetically and physically with Cox18p
Mitochondrial matrix protein that interacts with an N-terminal
region of mitochondrial RNA polymerase (Rpo41p) and couples
RNA processing and translation to transcription
Pho23
NAM9
N.D
Yng2
NGL1
CNOT6
Yng2
NTG1
NTHL1
Yng2,
Pho23
OM45
N.D
Yng2
PDX1
N.D
Yng2
PET123
N.D
Mitochondrial ribosomal component of the small subunit
Putative endonuclease, has a domain similar to a magnesiumdependent endonuclease motif in mRNA deadenylase Ccr4p; the
authentic, non-tagged protein is detected in highly purified
mitochondria in high-throughput studies
DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved
in base excision repair, localizes to the nucleus and mitochondrion
Protein of unknown function, major constituent of the
mitochondrial outer membrane; located on the outer (cytosolic)
face of the outer membrane
Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of
the mitochondrial pyruvate dehydrogenase (PDH) complex, plays
a structural role in the complex by binding and positioning E3 to
the dihydrolipoamide acetyltransferase (E2) core
Mitochondrial ribosomal protein of the small subunit; PET123
exhibits genetic interactions with PET122, which encodes a COX3
mRNA-specific translational activator
Yng2
PET127
N.D
Pho23
PET309
N.D
Pho23
PET56
N.D
Yng2
PET8
SLC25A26
Yng2
PIF1
C15orf20
Yng2
PIL1
N.D
Yng2
PNT1
N.D
Yng2
POS5
NADK
Yng2
PPA2
N.D
Yng2
PPX1
PRUNE
Yng2
PSD1
PISD
Yng2
PSP2
N.D
Yng2
PUT2
ALDH4A1
Yng2,
Pho23
Q0050
N.D
Pho23
Q0060
N.D
Yng2
QCR2
UQCRC2
Yng2
QRI7
OSGEPL1
Protein with a role in mitochondrial RNA stability and/or
processing, located in the mitochondrial membrane
Specific translational activator for the COX1 mRNA, also
influences stability of intron-containing COX1 primary transcripts;
located in the mitochondrial inner membrane
Ribose methyltransferase that modifies a functionally critical,
conserved nucleotide in mitochondrial 21S rRNA
S-adenosylmethionine transporter of the mitochondrial inner
membrane, member of the mitochondrial carrier family; required
for biotin biosynthesis and respiratory growth
DNA helicase involved in telomere formation and elongation; acts
as a catalytic inhibitor of telomerase; also plays a role in repair
and recombination of mitochondrial DNA
Primary component of eisosomes, which are large immobile cell
cortex structures associated with endocytosis; null mutants show
activation of Pkc1p/Ypk1p stress resistance pathways; detected in
phosphorylated state in mitochondria
Mitochondrial integral inner membrane protein involved in
membrane insertion of C-terminus of Cox2p, interacts genetically
and physically with Cox18p; deletion mutant sensitive to the antiPneumocystis carinii drug pentamidine
Mitochondrial NADH kinase, phosphorylates NADH; also
phosphorylates NAD(+) with lower specificity; required for the
response to oxidative stress
Mitochondrial inorganic pyrophosphatase, required for
mitochondrial function and possibly involved in energy generation
from inorganic pyrophosphate
Exopolyphosphatase, hydrolyzes inorganic polyphosphate (poly
P) into Pi residues; located in the cytosol, plasma membrane, and
mitochondrial matrix
catalyze formation of phosphatidylethanolamine from
phosphatidylserine. targeted to the inner mitochondrial membrane
Asn rich cytoplasmic protein that contains RGG motifs; high-copy
suppressor of group II intron-splicing defects of a mutation in
MRS2 and of a conditional mutation in POL1 (DNA polymerase
alpha); possible role in mitochondrial mRNA splicing
alh-6 is orthologous to the human gene ALDEHYDE
DEHYDROGENASE 4 FAMILY, MEMBER A1. Delta-1-pyrroline5-carboxylate dehydrogenase, nuclear-encoded mitochondrial
protein involved in utilization of proline as sole nitrogen source;
deficiency of the human homolog causes HPII, an autosomal
recessive inborn error of metabolism
Reverse transcriptase required for splicing of the COX1 premRNA, encoded by a mobile group II intron within the
mitochondrial COX1 gene
Endonuclease I-SceIII, encoded by a mobile group I intron within
the mitochondrial COX1 gene
Subunit 2 of the ubiquinol cytochrome-c reductase complex, which
is a component of the mitochondrial inner membrane electron
transport chain; phosphorylated; transcription is regulated by
Hap1p, Hap2p/Hap3p, and heme
Putative metalloprotease, similar to O-sialoglycoprotein
metallopeptidase from P. haemolytica; the authentic, non-tagged
protein is detected in highly purified mitochondria in highthroughput studies
Yng2
RPO41
POLRMT
Yng2
RSM23
N.D
Yng2
RSM27
N.D
Pho23
SHY1
SURF1
Pho23
STF1
N.D
Yng2
TIM11
N.D
Yng2,
Pho23
URA2
CAD
Yng2
VAS1
VARS
Yng2
YAT2
N.D
Yng2,
Pho23
YDL027C
N.D
Yng2
YDR196C
DCAKD
Yng2
YER053C
SLC25A3
Yng2
YER080
W
N.D
Yng2,
Pho23
YER140
W
TAPT1
Yng2
YGL057C
N.D
YNG1
YGL220
W
BOLA2B,
BOLA2
Mitochondrial RNA polymerase; single subunit enzyme similar to
those of T3 and T7 bacteriophages; requires a specificity subunit
encoded by MTF1 for promoter recognition
Mitochondrial ribosomal protein of the small subunit, has similarity
to mammalian apoptosis mediator proteins; null mutation prevents
induction of apoptosis by overproduction of metacaspase Mca1p
Mitochondrial ribosomal protein of the small subunit
Mitochondrial inner membrane protein required for assembly of
cytochrome c oxidase (complex IV); associates with complex IV
assembly intermediates and complex III/complex IV
supercomplexes; similar to human SURF1 involved in Leigh
Syndrome
(ATPIF1) Protein involved in regulation of the mitochondrial F1F0ATP synthase; Stf1p and Stf2p act as stabilizing factors that
enhance inhibitory action of the Inh1p protein
Subunit e of mitochondrial F1F0-ATPase, which is a large,
evolutionarily conserved enzyme complex required for ATP
synthesis; essential for the dimeric and oligomeric state of ATP
synthase
Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate
transcarbamylase (ATCase), catalyzes the first two enzymatic
steps in the de novo biosynthesis of pyrimidines; both activities
are subject to feedback inhibition by UTP. yr-1 is orthologous to
the human gene CARBAMYL PHOSPHATE SYNTHETASE I
(CPS1), which when mutated leads to hyperammonemia; PYR-1
protein is predicted to be mitochondrial with 68% accuracy.
Mitochondrial and cytoplasmic valyl-tRNA synthetase
Carnitine acetyltransferase; has similarity to Yat1p, which is a
carnitine acetyltransferase associated with the mitochondrial outer
membrane
Putative protein of unknown function; the authentic, non-tagged
protein is detected in highly purified mitochondria in highthroughput studies; YDL027C is not an essential gene
Putative dephospho-CoA kinase (DPCK) that catalyzes the final
step in Coenzyme A biosynthesis; essential for viability; the
authentic, non-tagged protein is detected in highly purified
mitochondria in high-throughput studies
Mitochondrial phosphate carrier, imports inorganic phosphate into
mitochondria; functionally redundant with Mir1p but less abundant
than Mir1p under normal conditions; expression is induced at high
temperature
Putative protein of unknown function; the authentic, non-tagged
protein is detected in highly purified mitochondria in highthroughput studies; null mutant displays decreased frequency of
mitochondrial genome loss
Putative protein of unknown function; the authentic, non-tagged
protein is detected in highly purified mitochondria in highthroughput studies
Putative protein of unknown function; the authentic, non-tagged
protein is detected in highly purified mitochondria in highthroughput studies; null mutant exhibits a growth defect on a nonfermentable (respiratory) carbon source
Putative protein of unknown function; (GFP)-fusion protein
localizes to the cytoplasm and the nucleus; null mutant displays
decreased mitochondrial genome loss (petite formation) and
severe growth defect in minimal glycerol media
Yng2
YGR046
W
AC083855
Yng2
YGR096
W
SLC25A19
Yng2
YGR150
C
N.D
Yng2
YGR257
C
SLC25A39
Yng2
YHL035C
N.D
Yng2
YIL077C
N.D
Pho23
YJL070C
AMPD2
Yng2
YJL131C
N.D
Yng2,
Pho23
YJL147C
N.D
Yng2
YJR070C
DOHH
Yng2
YJR080C
N.D
Yng2
YJR100C
PLSCR1
Yng2
YJR136C
N.D
Yng2
YKR023
W
N.D
Pho23
YLR132C
N.D
Mitochondrial protein involved in protein import into the
mitochondrial matrix; maintains the functional integrity of the
TIM23 protein translocator complex; viability of null mutant is
strain-dependent; mRNA is targeted to the bud
Mitochondrial membrane transporter that mediates uptake of the
essential cofactor thiamine pyrophosphate (ThPP) into
mitochondria; expression appears to be regulated by carbon
source; member of the mitochondrial carrier family
Protein of unknown function, contains PPR motifs; mutant has
growth defects on both non-fermentable carbon sources and rich
medium; the authentic, non-tagged protein is detected in highly
purified mitochondria in high-throughput studies
Mitochondrial protein of the mitochondrial carrier family, involved
in activating mitochondrial Sod2p probably by facilitating insertion
of an essential manganese cofactor
Protein of unknown function that may interact with ribosomes,
based on co-purification experiments; member of the ATP-binding
cassette (ABC) family; potential Cdc28p substrate; detected in
purified mitochondria in high-throughput studies
Putative protein of unknown function; the authentic, non-tagged
protein is detected in highly purified mitochondria in highthroughput studies; deletion confers sensitivity to 4-(N-(Sglutathionylacetyl)amino) phenylarsenoxide
Putative protein of unknown function with similarity to AMP
deaminases; the authentic, non-tagged protein is detected in
highly purified mitochondria in high-throughput studies
Putative protein of unknown function; the authentic non-tagged
protein is detected in highly purified mitochondria; null mutant is
viable, displays increased frequency of mitochondrial genome loss
Mitochondrial protein of unknown function; homozygous diploid
deletion strain has a sporulation defect characterized by elevated
dityrosine in the soluble fraction; expression induced by calcium
shortage
Deoxyhypusine hydroxylase, a HEAT-repeat containing
metalloenzyme that catalyses hypusine formation; binds to and is
required for the modification of Hyp2p (eIF5A); complements S.
pombe mmd1 mutants defective in mitochondrial positioning
Protein of unknown function; non-tagged protein is detected in
purified mitochondria in high-throughput studies; null mutant
displays increased frequency of mitochondrial genome loss and
reduced growth rate in minimal glycerol media
Putative protein of unknown function; non-tagged protein is
detected in purified mitochondria in high-throughput studies; null
mutant displays increased frequency of mitochondrial genome
loss (petite formation); similar to murine NOR1
Putative protein of unknown function; may interact with
mitochondrial ribosomal protein Rsm23p; green fluorescent
protein (GFP)-fusion protein localizes to the cytoplasm
Putative protein of unknown function; the authentic, non-tagged
protein is detected in highly purified mitochondria in highthroughput studies
Protein of unknown function; green fluorescent protein (GFP)tagged protein localizes to mitochondria and nucleus; YLR132C is
an essential gene
Yng2,
Pho23
YLR247C
N.D
Pho23
YLR253
W
ADCK1
Yng2
YLR419
W
DHX29
Yng2
YMC2
SLC25A29
Yng2
YMR098
C
N.D
Yng2
YMR115
W
N.D
YNG1
YNL168C
FAHD1
Yng2
YNL177C
N.D
Yng2
YNL195C
N.D
Yng2
YNL320
W
ABHD13
Yng2
YNR040
W
N.D
Yng2
YOR227
W
YOR228
C
Yng2,
Pho23
YPL005W
N.D
Yng2
YPL105C
GIGYF1
Yng2
YPL109C
ADCK2
Yng2
YPL158C
N.D
Yng2
N.D
N.D
Putative helicase; localized to mitochondria and the nucleus;
YLR247C is not an essential gene; null mutant displays increased
levels of spontaneous Rad52 foci
Putative protein of unknown function; the authentic, non-tagged
protein is detected in highly purified mitochondria in highthroughput studies; transcription is periodic during the metabolic
cycle
Putative helicase with limited sequence similarity to human Rb
protein; the authentic, non-tagged protein is detected in highly
purified mitochondria in high-throughput studies
Mitochondrial protein, putative inner membrane transporter with a
role in oleate metabolism and glutamate biosynthesis; member of
the mitochondrial carrier (MCF) family; has similarity with Ymc1p
Protein of unknown function; non-tagged protein is detected in
highly purified mitochondria; null mutant displays decreased
frequency of mitochondrial genome loss (petite formation) and
severe growth defect in minimal glycerol media
Putative protein of unknown function; the authentic, non-tagged
protein is detected in highly purified mitochondria in highthroughput studies
Putative protein of unknown function; GFP-fusion protein is
induced in response to the DNA-damaging agent MMS; the
authentic, non-tagged protein is detected in highly purified
mitochondria in high-throughput studies
Mitochondrial ribosomal protein of the large subunit
Putative protein of unknown function; shares a promoter with
YNL194C; the authentic, non-tagged protein is detected in highly
purified mitochondria in high-throughput studies
Putative protein of unknown function; the authentic, non-tagged
protein is detected in highly purified mitochondria in highthroughput studies
Putative protein of unknown function; the authentic, non-tagged
protein is detected in highly purified mitochondria in highthroughput studies
Protein of unknown function that may interact with ribosomes,
based on co-purification experiments; authentic, non-tagged
protein is detected in highly purified mitochondria in highthroughput studies
Protein of unknown function, localized to the mitochondrial outer
membrane
Peripheral mitochondrial inner membrane protein, located on the
matrix face of the membrane; stabilizes the bicistronic AAP1ATP6 mRNA encoding subunits 6 and 8 of the ATP synthase
complex
Protein of unknown function that may interact with ribosomes,
based on co-purification experiments; authentic, non-tagged
protein is detected in highly purified mitochondria in highthroughput studies
Putative protein of unknown function; the authentic, non-tagged
protein is detected in highly purified mitochondria in highthroughput studies
Protein of unknown function; null mutant displays increased
frequency of mitochondrial genome loss (petite formation) and
reduced growth rate in minimal glycerol media
Yng2
YPL159C
N.D
Yng2
YPL222W
AL022328
Yng2
YPR140
W
TAZ
Yng2,
Pho23
YSC83
N.D
Yng2
ZMS1
N.D
Mitochondrial protein, required for respiratory growth under some
conditions and for stability of the mitochondrial genome
Putative protein of unknown function; the authentic, non-tagged
protein is detected in highly purified mitochondria in highthroughput studies
Lyso-phosphatidylcholine acyltransferase, required for normal
phospholipid content of mitochondrial membranes; may remodel
acyl groups of cardiolipin in the inner membrane; similar to human
tafazzin, which is implicated in Barth syndrome
Non-essential mitochondrial protein of unknown function; mRNA
induced during meiosis, peaking between mid to late prophase of
meiosis I
Zinc-finger protein involved in transcriptional control of both
nuclear and mitochondrial genes, many of which specify products
required for glycerol-based growth, respiration, and other
functions
*N.D – Orthologs could not be determined or narrowed down by sequence analysis
**The yeast gene functions were taken from NCBI gene database or Saccharomyces Gene Database
Supplementary Table 1