Carnitine metabolism and biosynthesis in yeast Saccharomyces
... those beneficial impacts appear not to be directly linked to shuttle activity. This study makes use of the yeast Saccharomyces cerevisiae as a cellular model system in order to study the impact of carnitine and of the carnitine shuttle on cellular physiology, and also investigates the eukaryotic car ...
... those beneficial impacts appear not to be directly linked to shuttle activity. This study makes use of the yeast Saccharomyces cerevisiae as a cellular model system in order to study the impact of carnitine and of the carnitine shuttle on cellular physiology, and also investigates the eukaryotic car ...
Carnitine-Metabolism and Functions
... studies in the 193Os, such studies did not reveal any definite evidence either for the physiological role of carnitine or for its biosynthesis or degradation. In 1952 Carter et al. (89) created new interest in carnitine when they established that it is a growth factor for the meal worm Tenebrio moZi ...
... studies in the 193Os, such studies did not reveal any definite evidence either for the physiological role of carnitine or for its biosynthesis or degradation. In 1952 Carter et al. (89) created new interest in carnitine when they established that it is a growth factor for the meal worm Tenebrio moZi ...
REGULATION OF CYTOCHROME P450 BY
... sequencing of entire genomes, researchers have identified and continue to discover many P450 enzymes in a wide variety of organisms. In order to systematically identify and categorize this growing family of enzymes, a leading group of researchers in the field established the current system of nomenc ...
... sequencing of entire genomes, researchers have identified and continue to discover many P450 enzymes in a wide variety of organisms. In order to systematically identify and categorize this growing family of enzymes, a leading group of researchers in the field established the current system of nomenc ...
Ketone Body Metabolism Preserves Hepatic Function during
... Semenkovich, Tom Baranski, and D. Andre d’Avignon. No one has spent more time in the trenches with me than Andre, who has even come into work at 11:30 PM, beer in hand, to help me trouble shoot intrument problems. Most importantly, this work would not exist without the unwavering support, guidance, ...
... Semenkovich, Tom Baranski, and D. Andre d’Avignon. No one has spent more time in the trenches with me than Andre, who has even come into work at 11:30 PM, beer in hand, to help me trouble shoot intrument problems. Most importantly, this work would not exist without the unwavering support, guidance, ...
Regulation of Urea Synthesis by Agmatine in the Perfused Liver
... molecule in regulating the urea cycle remains to be defined. In the current investigation we have explored the hypothesis that dietary arginine (whether free or as a part of a high protein diet), is decarboxylated to agmatine in hepatic mitochondria, and that agmatine, not arginine, is the regulator ...
... molecule in regulating the urea cycle remains to be defined. In the current investigation we have explored the hypothesis that dietary arginine (whether free or as a part of a high protein diet), is decarboxylated to agmatine in hepatic mitochondria, and that agmatine, not arginine, is the regulator ...
Lactic Acidosis: Recognition, Kinetics, and Associated Prognosis
... shock patients.33 Initial and final phase lactate levels were lower in survivors whereas DO2 and VO2 were not different. Bakker and colleagues34 showed that lactime, or duration of elevated serum lactate levels, most accurately corresponded to organ failure and death and did so better than initial l ...
... shock patients.33 Initial and final phase lactate levels were lower in survivors whereas DO2 and VO2 were not different. Bakker and colleagues34 showed that lactime, or duration of elevated serum lactate levels, most accurately corresponded to organ failure and death and did so better than initial l ...
Production and Utilization of Acetate in Mammals
... Initial experiments on the intracellular distribution of acetyl-CoA synthetase and acetyl-CoA hydrolase were performed by differential centrifugation of homogenates in 0.25M-sucrose (Schneider & Hogeboom, 1950). Although the particulate activities of the two enzymes were associated with the mitochon ...
... Initial experiments on the intracellular distribution of acetyl-CoA synthetase and acetyl-CoA hydrolase were performed by differential centrifugation of homogenates in 0.25M-sucrose (Schneider & Hogeboom, 1950). Although the particulate activities of the two enzymes were associated with the mitochon ...
Metabolic regulation via intracellular pH - AJP
... RESULTS. Nearly 50 yr passed without further progress until Steinhardt and Mazia (215), building on the work of Loeb, demonstrated that NH3 (in the form of seawater titrated to pH 9.1 with NH40H) activates one of the “late” events of fertilization, the appearance of new K+ conductance, in unfertiliz ...
... RESULTS. Nearly 50 yr passed without further progress until Steinhardt and Mazia (215), building on the work of Loeb, demonstrated that NH3 (in the form of seawater titrated to pH 9.1 with NH40H) activates one of the “late” events of fertilization, the appearance of new K+ conductance, in unfertiliz ...
ABA overlysensitive5 (ABO5), encoding a pentatricopeptide repeat
... ROS production, and an alternative oxidase (AOX), which directly accepts electrons from the ubiquinone pool for reducing ROS production. These alternative pathways increase the tolerance of plant mitochondria to respiratory defects, and loss of complex I has diverse effects on plant cells. For examp ...
... ROS production, and an alternative oxidase (AOX), which directly accepts electrons from the ubiquinone pool for reducing ROS production. These alternative pathways increase the tolerance of plant mitochondria to respiratory defects, and loss of complex I has diverse effects on plant cells. For examp ...
Localization and nucleotide specificity of Blastocystis succinyl‐CoA
... infecting up to 10% of the developed world (Stenzel and Boreham, 1996). However, the role Blastocystis has in causing actual disease, if any, is still a matter of dispute. It is one of the few known human parasites within the stramenopiles (Silberman et al., 1996), a group also containing, for examp ...
... infecting up to 10% of the developed world (Stenzel and Boreham, 1996). However, the role Blastocystis has in causing actual disease, if any, is still a matter of dispute. It is one of the few known human parasites within the stramenopiles (Silberman et al., 1996), a group also containing, for examp ...
Nicotinamide adenine dinucleotide, a metabolic regulator of
... as Npt1p, are localised primarily to the nucleus, whereas components of the de novo pathway reside evenly throughout the cell and have no effect on silencing [14,15]. NAD also regulates gene expression at other genomic loci. Clock/BMAL1 and NPAS2/BMAL1 are heterodimeric transcription factors that r ...
... as Npt1p, are localised primarily to the nucleus, whereas components of the de novo pathway reside evenly throughout the cell and have no effect on silencing [14,15]. NAD also regulates gene expression at other genomic loci. Clock/BMAL1 and NPAS2/BMAL1 are heterodimeric transcription factors that r ...
Intermediary metabolism
... Recent estimates for the last common ancestor to vertebrates and nematodes range from 800 million to over one billion years ago (Hedges and Kumar, 2003; Hedges, 2002; Ureta-Vidal et al., 2003; Blaxter, 1998). Since that time, nematodes have developed a bewildering variety of life histories including ...
... Recent estimates for the last common ancestor to vertebrates and nematodes range from 800 million to over one billion years ago (Hedges and Kumar, 2003; Hedges, 2002; Ureta-Vidal et al., 2003; Blaxter, 1998). Since that time, nematodes have developed a bewildering variety of life histories including ...
Analysis and engineering of acetyl
... strating that the natifie cytosolic acetyl-CoA synthesis pathflay can be ffflly replaced, Chapter 3 also refiealed targets that need to be addressed to achiefie optimal in vivo performance of the alternatifie reactions for sffpply of cytosolic acetyl-CoA. Design and implementation of metabolic engineering st ...
... strating that the natifie cytosolic acetyl-CoA synthesis pathflay can be ffflly replaced, Chapter 3 also refiealed targets that need to be addressed to achiefie optimal in vivo performance of the alternatifie reactions for sffpply of cytosolic acetyl-CoA. Design and implementation of metabolic engineering st ...
PDF - Circulation Research
... Given that the heart is a metabolically versatile organ capable of utilizing a large range of substrates, the main features of cardiac metabolic networks merit a brief review. For more detail, please refer to the literature listed in the Appendix. Metabolic networks for the utilization of energy-pro ...
... Given that the heart is a metabolically versatile organ capable of utilizing a large range of substrates, the main features of cardiac metabolic networks merit a brief review. For more detail, please refer to the literature listed in the Appendix. Metabolic networks for the utilization of energy-pro ...
Mechanistic studies on the diazo transfer reaction
... As reported in the literature the diazo transfer reaction can be used to modify enzymes, antibiotics, and proteins to study their functions or to modify their activity. But in these cases, the Cu(II) catalyst is avoided lest it have any adverse effect on the structure or biological function of the p ...
... As reported in the literature the diazo transfer reaction can be used to modify enzymes, antibiotics, and proteins to study their functions or to modify their activity. But in these cases, the Cu(II) catalyst is avoided lest it have any adverse effect on the structure or biological function of the p ...
REPRODUCTION
... commonly used to study oocyte development in several mammalian species, and has application to assisted reproduction in humans and livestock animal production (Trounson et al. 2001, Gilchrist & Thompson 2007, Hashimoto 2009). Oocyte maturation involves the resumption of meiosis from prophase I (germ ...
... commonly used to study oocyte development in several mammalian species, and has application to assisted reproduction in humans and livestock animal production (Trounson et al. 2001, Gilchrist & Thompson 2007, Hashimoto 2009). Oocyte maturation involves the resumption of meiosis from prophase I (germ ...
REDESIGN OF CARNITINE ACETYLTRANSFERASE SPECIFICITY BY PROTEIN ENGINEERING UNIVERSIDAD DE BARCELONA
... dietary uptake. Dietary carnitine is especially required in early infancy when the capacity for carnitine biosynthesis is limited (Borum, 1983) and for patients on hemodialysis. Carnitine is found at the highest concentrations in heart and skeletal muscle of vertebrates, and unusually high concentra ...
... dietary uptake. Dietary carnitine is especially required in early infancy when the capacity for carnitine biosynthesis is limited (Borum, 1983) and for patients on hemodialysis. Carnitine is found at the highest concentrations in heart and skeletal muscle of vertebrates, and unusually high concentra ...
The influence of age and type 2 diabetes on
... bedside regarding the susceptibility to myocardial infarction with old age and diabetes. In laboratories all over the world, strategies have been developed to protect the myocardium from this insult, including the use of ischaemic conditioning (short periods of ischaemia and reperfusion prior to or ...
... bedside regarding the susceptibility to myocardial infarction with old age and diabetes. In laboratories all over the world, strategies have been developed to protect the myocardium from this insult, including the use of ischaemic conditioning (short periods of ischaemia and reperfusion prior to or ...
Document
... • Beta-Oxidation proper in the mitochondrial matrix • Fatty acids are oxidized by most of the tissues in the body. • Brain, erythrocytes and adrenal medulla cannot utilize fatty acids for energy requirement. ...
... • Beta-Oxidation proper in the mitochondrial matrix • Fatty acids are oxidized by most of the tissues in the body. • Brain, erythrocytes and adrenal medulla cannot utilize fatty acids for energy requirement. ...
Biomarker discovery for psychiatric disorders
... Although over the last century tremendous progress has been made in the therapy and mortality decrease of devastating conditions such as cancer and cardiopathies, no decrease has been observed in mortality rates or overall prevalence of psychiatric disorders (Kessler et al., 2005). It is therefore n ...
... Although over the last century tremendous progress has been made in the therapy and mortality decrease of devastating conditions such as cancer and cardiopathies, no decrease has been observed in mortality rates or overall prevalence of psychiatric disorders (Kessler et al., 2005). It is therefore n ...
Molecular Neurobiology - Universidad Autónoma de Madrid
... Current work involves the study of functional mechanism, biogenesis, intracellular trafficking, regulation of CNS glycine transporters, GlyT1 and GlyT2, plasma membrane proteins responsible for the completion of glycinergic transmission. Our research is oriented towards CNS pathologies associated wi ...
... Current work involves the study of functional mechanism, biogenesis, intracellular trafficking, regulation of CNS glycine transporters, GlyT1 and GlyT2, plasma membrane proteins responsible for the completion of glycinergic transmission. Our research is oriented towards CNS pathologies associated wi ...
Phosphorylation of the F1Fo ATP Synthase Я Subunit
... charged residue to mimic phosphorylation. The alanine mutations act as a control mutation by ensuring backbone spacing is retained, without the possibility of phosphorylation. The model system is an essential tool because 100% of ATP are modified at the same site and all ATP synthase complexes cont ...
... charged residue to mimic phosphorylation. The alanine mutations act as a control mutation by ensuring backbone spacing is retained, without the possibility of phosphorylation. The model system is an essential tool because 100% of ATP are modified at the same site and all ATP synthase complexes cont ...
Carnitine Overview
... dynamic balance with acylcarnitines with the acyl to free Carnitine ratio of ≤ 0.4 being considered normal. ...
... dynamic balance with acylcarnitines with the acyl to free Carnitine ratio of ≤ 0.4 being considered normal. ...
Characterization of carnitine and fatty acid metabolism in the long
... RESULTS AND DISCUSSION Method development ...
... RESULTS AND DISCUSSION Method development ...
Balancing between respiration and fermentation - UvA-DARE
... thiss carrier have been identified, with different expression patterns depending on aerobic and anaerobicc conditions [59, 60, 108, 114, 143]. In an aac2 background, S. cerevisiae is unable to producee viable petites [109], thus resembling petite-negative yeasts. In parallel with the F ^ ATPP syntha ...
... thiss carrier have been identified, with different expression patterns depending on aerobic and anaerobicc conditions [59, 60, 108, 114, 143]. In an aac2 background, S. cerevisiae is unable to producee viable petites [109], thus resembling petite-negative yeasts. In parallel with the F ^ ATPP syntha ...