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... apoptosis inducing factor (AIF), begin a cascade of proteolytic activity that ultimately leads to nuclear damage (DNA fragmentation, DNA mutations) and cell death. Cytochrome c appears to act by forming multimeric complexes with Apaf-1, which in turn activate procaspase 9, and begin a cascade of act ...
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... remaining genes are encoded in the cell nucleus and the resultant proteins are transported to the mitochondria. Only about 3% of the genes necessary to make a mitochondrion (100 of the 3000) are allocated for making ATP. More than 95% (2900 of 3000) are involved with other functions tied to the spec ...
< 1 ... 34 35 36 37 38

Mitochondrial replacement therapy

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