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Download Gene Section MDS2 (myelodysplastic syndrome 2 translocation associated) Atlas of Genetics and Cytogenetics
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Transcript
Atlas of Genetics and Cytogenetics in Oncology and Haematology OPEN ACCESS JOURNAL AT INIST-CNRS Gene Section Short Communication MDS2 (myelodysplastic syndrome 2 translocation associated) Jean-Loup Huret, Sylvie Senon Genetics, Dept Medical Information, UMR 8125 CNRS, University of Poitiers, CHU Poitiers Hospital, F86021 Poitiers, France (JLH, SS) Published in Atlas Database: July 2003 Online updated version: http://AtlasGeneticsOncology.org/Genes/MDS2ID476.html DOI: 10.4267/2042/37984 This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 France Licence. © 2003 Atlas of Genetics and Cytogenetics in Oncology and Haematology Identity Protein HGNC (Hugo): MDS2 Location: 1p36 Location (base pair): 23024 Description The 4 alternate splicings give rise to 2 proteins, of 82 and 140 amino acids. Expression Wide. Implicated in t(1;12)(p36;p13) in myeloid disorders Prognosis Unknown so far. Hybrid/Mutated gene 5' ETV6 - 3' MDS2. Abnormal protein Truncated ETV6. Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics. DNA/RNA Description Spans 13 kb; 7 exons. Transcription References 4 alternate splicings; major splice: 281 bp, exons 1, 4, 6, 7 are constantly used. Odero MD, Vizmanos JL, Román JP, Lahortiga I, Panizo C, Calasanz MJ, Zeleznik-Le NJ, Rowley JD, Novo FJ. A novel gene, MDS2, is fused to ETV6/TEL in a t(1;12)(p36.1;p13) in a patient with myelodysplastic syndrome. Genes Chromosomes Cancer. 2002 Sep;35(1):11-9 This article should be referenced as such: Huret JL, Senon S. MDS2 (myelodysplastic syndrome 2 translocation associated). Atlas Genet Cytogenet Oncol Haematol. 2003; 7(3):174. Atlas Genet Cytogenet Oncol Haematol. 2003; 7(3) 174
