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Download Gene Section TCTA (T-cell leukemia translocation-associated gene) Atlas of Genetics and Cytogenetics
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Transcript
Atlas of Genetics and Cytogenetics in Oncology and Haematology OPEN ACCESS JOURNAL AT INIST-CNRS Gene Section Short Communication TCTA (T-cell leukemia translocation-associated gene) Jean-Loup Huret Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France Published in Atlas Database: March 1998 Online updated version: http://AtlasGeneticsOncology.org/Genes/TCTA.html DOI: 10.4267/2042/37412 This work is licensed under a Creative Commons Attribution-Non-commercial-No Derivative Works 2.0 France Licence. © 1998 Atlas of Genetics and Cytogenetics in Oncology and Haematology Homology Identity None is known. Location: 3p21 Implicated in DNA/RNA t(1;3)(p32;p21)/T-cell ALL → TAL1/TCTA Disease T-cell ALL. Hybrid/Mutated Gene Head to head orientation of TAL1 and TCTA. Abnormal Protein No fusion protein, but possibly promoter exchange and gene disregulation. DNA diagram Transcription 2.1 kb mRNA. Protein To be noted Description Note: on day 04 Feb 1998, nothing new has appeared since the above coted paper. 103 amino acids; 11 kDa; rich in hydrophobic amino acids (residues 41-61). References Expression Wide, especially in kidneys. Aplan PD, Johnson BE, Russell E, Chervinsky DS, Kirsch IR. Cloning and characterization of TCTA, a gene located at the site of a t(1;3) translocation. Cancer Res 1995 May 1;55(9):1917-21. Localisation May be a membrane associated protein, as there is a hydrophobic domain. This article should be referenced as such: Function Huret JL. TCTA (T-cell leukemia translocation-associated gene). Atlas Genet Cytogenet Oncol Haematol.1998;2(2):51. Unknown. Atlas Genet Cytogenet Oncol Haematol. 1998;2(2) 51
