Download Gene Section AF17 (ALL1 fused gene from chromosome 17)

Atlas of Genetics and Cytogenetics
in Oncology and Haematology
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Gene Section
Short Communication
AF17 (ALL1 fused gene from chromosome 17)
Jean-Loup Huret
Genetics, Department of Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021
Poitiers, France
Published in Atlas Database: December 1997
Online version is available at: http://AtlasGeneticsOncology.org/Genes/AF17.html
DOI: 10.4267/2042/32047
This work is licensed under a Creative Commons Attribution-Non-commercial-No Derivative Works 2.0 France Licence.
© 1997 Atlas of Genetics and Cytogenetics in Oncology and Haematology
Identity
Implicated in
Other names: MLLT6 (myeloid/lymphoid leukemia
translocated to, 6)
Location: 17q21
Local order: proximal to RARA, also in 17q21; HLF
is even more distal in 17q22.
t(11;17)(q23;q21)/ANLL → MLL/AF17
Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular
Cytogenetics.
Disease
ANLL and MDS.
Cytogenetics
Additional anomaly: +8.
Hybrid/Mutated Gene
5’ MLL - 3’ AF17.
Abnormal Protein
N-term AT hook and DNA methyltransferase from
MLL fused to the leucine zipper C-term of AF17.
DNA/RNA
References
Transcription
Prasad R, Leshkowitz D, Gu Y, Alder H, Nakamura T, Saito H,
Huebner K, Berger R, Croce CM, Canaani E. Leucine-zipper
dimerization motif encoded by the AF17 gene fused to ALL-1
(MLL) in acute leukemia. Proc Natl Acad Sci USA 1994 Aug
16;91(17):8107-8111.
7.5 and 5 kb mRNA; coding sequence: 3.3 kb.
Protein
Bernard OA and Berger R. Molecular basis of 11q23
rearrangements in hematopoietic malignant proliferations.
Genes Chromosomes Cancer 1995 Jun;13(2):75-85.
Description
1093 amino acids; N-term - 3 Zn fingers (LAP type)
and a leucine zipper - C-term; a leucine zipper is a
dimerization motif.
Young BD and Saha V. Chromosome abnormalities in
leukemia: the 11q23 paradigm. Cancer Surv 1996;28:225-245.
Rubnitz JE, Behm FG, Downing JR. 11q23 rearrangements in
acute leukemia. Leukemia 1996 Jan;10(1):74-82. (Review).
Localisation
Nuclear.
This article should be referenced as such:
Function
Huret JL. AF17 (ALL1 fused gene from chromosome 17). Atlas
Genet Cytogenet Oncol Haematol.1997;1(2):53.
Transcriptional regulation factor.
Homology
With AF10 and BR140, a gene sitting in 3p25.
Atlas Genet Cytogenet Oncol Haematol. 1997;1(2)
53