Download Gene Section EEN (extra eleven nineteen leukemia fusion gene)

Atlas of Genetics and Cytogenetics
in Oncology and Haematology
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Gene Section
Short Communication
EEN (extra eleven nineteen leukemia fusion gene)
Jean-Loup Huret
Genetics, Department of Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021
Poitiers, France
Published in Atlas Database: December 1997
Online version is available at: http://AtlasGeneticsOncology.org/Genes/EEN.html
DOI: 10.4267/2042/32053
This work is licensed under a Creative Commons Attribution-Non-commercial-No Derivative Works 2.0 France Licence.
© 1997 Atlas of Genetics and Cytogenetics in Oncology and Haematology
Identity
Implicated in
Location: 19p13
t(11;19)(q23;p13)/ANLL → MLL/EEN
DNA/RNA
Disease
Yet unknown (only one case).
Hybrid/Mutated Gene
5’ MLL - 3’ EEN; breakpoint at exon 6 of MLL.
Abnormal Protein
Includes the N-term of MLL (with the AT hook and
DNA binding motifs) and the major functional domain
of EEN.
Transcription
Multiple transcript sizes, from 1 kb to the major form
of 2.6 kb.
Protein
Description
368 amino acids; 46 kDa (major product); contains a
central alpha-helical region and a SH3 (SRC homology
3) domain in C-term.
References
So CW, Caldas C, Liu MM, Chen SJ, Huang QH, Gu LJ, Sham
MH, Wiedemann LM, Chan LC. EEN encodes for a member of
a new family of proteins containing an Src homology 3 domain
and is the third gene located on chromosome 19p13 that fuses
to MLL in human leukemia. Proc Natl Acad Sci U S A. 1997
Mar 18;94(6):2563-8.
Expression
Wide, especially in the pancreas.
Homology
GRB2.
This article should be referenced as such:
Huret JL. EEN (extra eleven nineteen leukemia fusion gene).
Atlas Genet Cytogenet Oncol Haematol.1997;1(2):64.
Atlas Genet Cytogenet Oncol Haematol. 1997;1(2)
64