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Microarray analysis each spot represents one gene Yellow: no change in gene expression Green: the gene is Red: the gene is turned off in the tumor turned on in the tumor Analyzing Human Breast Cancer Types By Microarray Analysis Identifying genes whose expression changes at specific stages of the cell cycle day night day night day night Circadian Rhythms and Sleep Genes whose expression changes during the day in fruit flies (and people) Implications for sleep disorders Arp3 Arp3 Arp2 Arc40 Arc35 18 19 15 35 Arp2 Arc19 Arc18 Arc15 40 QuickTime™ and a GIF decompressor are needed to see this picture. Example from Bruce Goode, QuickTime™ and a Photo - JPEG decompressor are needed to see this picture. Fig. 1. Representation of chromosome V incorporating genetic footprinting data. Each box is colored to summarize the results obtained to date from genetic footprinting. Mutant phenotypes: Q1, all selections, <75% population growth rate; Q2, all selections, 75 to 85% population growth rate; Q3, all selections, 85 to <100% population growth rate. Genes in which mutations gave distinctive phenotypes under specific selections are colored according to the selection(s) affected, as follows: M: (dark green),: minimal medium;. L (teal),: lactate medium;. H (orange),: high temperature;. C (brown),: caffeine;. S (yellow),: high salt;. X (light green),: mating;. WT (dark blue),: wild-type for all selections;. NR (grey) QuickTime™ and a GIF decompressor are needed to see this picture. QuickTime™ and a GIF decompressor are needed to see this picture. bim1 x rad54