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Transcript
Beadle and Tatum â One gene, one enzyme ï® 1940s â isolated mutants that disrupted synthesis of arginine ï® ï® ï® ï® Auxotroph â needs supplement to grow on minimal media Prototroph âneeds no supplement Recombination analysis - mutations in four distinct regions of genome Complementation tests - each of four regions correlated with a different complementation group (4 different genes) 42
