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Intro to DNA Replication A QUICK REFRESHER • Where is DNA found? • nucleus • Where else? • mitochondria, chloroplast (the endosymbiont theory) • What form does DNA take in the nucleus? • chromosome • How do the 150 million base pairs that make up the human genome fit into the nucleus? • wrapped around histones • coiled and supercoiled chromatin condenses into chromosomes • What is a karyotype? • A picture of all the chromosomes found in a cell • How many chromsomes are found in a human somatic cell? • 23 pairs (46 total) • How many chromosomes are found in human gametes? • 23 • Is this person male or female? • male • All cells can give rise to a new generation of cells via the cell cycle •S phase of interphase •DNA replicates • Mitosis • Replicated DNA splits between two nuclei • Cytokinesis • Cytoplasm splits between two daughter cells • Each daughter cell has an exact copy of the parent cell’s DNA Meselson and Stahl DNA Replication - The Process