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Section of Spinal Cord Lab I and II 神經科學實驗:脊隨 王昭穎 助理教授 國防醫學院生物及解剖學科 [email protected] 18713 General Organization The spinal cord is housed within the vertebral column General Organization There are 31 segments in the spinal cord: 8 cervical (C1 - C8) 12 Thoracic (T1 - T12) 5 Lumbar (L1 - L5) 5 Sacral (S1 - S5) 1 Coccygeal The Spinal Cushing system(Meninges) General Organization Cross Section of The Spinal Cord Cross Sectional Organization Sectional Anatomy of the Spinal Cord Gray matter Central canal Consists of somas (cell bodies) surrounding the central canal White matter Consists of axons Nerves are organized into tracts or columns Located outside the gray matter area Cord Sections -- Cervical Cervical cord is wide, flat, almost oval in appearance Cord Sections -- Cervical Enlargement Cervical Cervical Enlargement Cord Section -- Thoracic Less white matter than cervical Rounder appearance Less prominent ventral horns than cervical enlargement Cord Section -- Lumbar Lumbar Less white matter than thoracic Rounder appearance Larger ventral horns, especially in lumbar enlargement Lumbar Enlargement Cord Section -- Sacral The proportion of gray matter is largest Not much white matter The diameter of the spinal cord is the smallest Gray Matter: Functional Organization Rexed’s lamina(layers)-Dorsal horn Lissauer’s tract (dorsolateral fasciculus) Lamina II, is called the substantia gelantinosa Lamina III & IV form what is also called the nucleus proprius Lamina VII (C8-L3) the Clarke's column, (or the nucleus thoracic or dorsalis), origin of the spinocerebellar tract Rexed’s lamina(layers)-Vental horn Lamina IX: alpha and gamma motor neurons Grey Matter: Posterior Horn Mostly Interneurons Substantia gelatinosa Pain/temp proc Body of the posterior horn Sensory proc Grey Matter: Intermediate Grey Clarke’s Column T1-L3 Balance/proprio. Intermediolateral Column T1-L3 Sympathetic neurons Grey Matter: Anterior Horn Lower Motor Neurons White Matter Sensory Pathway Neuron Definition Three major pathways carry sensory information 1. Posterior column pathway 2. Spinothalamic (Anterolateral) tract 3. Spinocerebellar(Anteroposterior) tract 1. 3. 2. 1.Posterior column pathway Carries fine touch, pressure and proprioceptive sensations Axons ascend within the fasculus gracillis and cuneatus Fasciculus gracilis Transmits information coming from areas inferior to T6 Fasciculus cuneatus Transmits information coming from areas superior to T6 Decussation in medulla oblongata Relay information to the thalamus via the medial lemniscus 2.Spinothalamic pathway Headed toward the ventral nuclei of the thalamus Carries poorly localized sensations of touch, pressure(anterior), pain and temperature(lateral) Axons decussate first in the spinal cord then ascend Spinothalamic pathway 3.Spinocerebellar pathway Include the posterior and anterior spinocerebellar tracts Carries sensation to the cerebellum concerning position of muscles, tendons and joints White Matter Motor pathways and Descending Tracts Originate from the cerebral cortex and brain stem Concerned with: Control of movements Muscle tone Spinal reflexes and equilibrium Modulation of sensory transmission to higher centers The motor pathways are divided into two groups Direct pathways (voluntary motion pathways) The pyramidal tracts (corticospinal) Indirect pathways (postural pathways) The extrapyramidal pathways The Corticospinal Tract Originate in the pyramidal neurons in the precentral gyri. Concerned with voluntary, discrete, skilled movements. Impulses are sent through the corticospinal tracts and synapse in the contralateral side of anterior horn. Part of the direct pathway, called corticobulbar tracts, innervates cranial nerve nuclei. Axons pass through corona radiata, internal capsule, crus cerebri and pyramid of medulla oblongata. In the caudal medulla about 75-90% of the fibers decussate and form the lateral corticospinal tract. Rest of the fibers remain ipsilateral and form anterior corticospinal tract. They also decussate before termination. Other Motor Tracts √ Voluntary Motor √ √ √ The Subconscious Motor Tracts Consists of four tracts involved in monitoring the subconscious motor control Vestibulospinal tracts Tectospinal tracts Reticulospinal tracts Rubrospinal tracts The Subconscious Motor Tracts Vestibulospinal tracts Send information from the inner ear to monitor position of the head Vestibular nuclei respond by altering muscle tone, neck muscle contraction, and limbs for posture and balance Vestibulospinal tracts The Subconscious Motor Tracts Tectospinal tracts Send information to the head, neck, and upper limbs in response to bright and sudden movements and loud noises The tectum area consists of superior and inferior colliculi Superior colliculi: receives visual information Inferior colliculi: receives auditory information Tectospinal tracts and Rubrospinal tracts The Subconscious Motor Tracts Rubrospinal tracts Send information to the flexor and extensor muscles Reticulospinal tracts Send information to cause eye movements and activate respiratory muscles Reticulospinal tracts Ascending and Descending Tracts Spinal Cord Blood Supply Ventral Dorsal Spinal Cord Blood Supply Checking list 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. Which segment of spinal cord(C, T, L, or S) Caudal equina Filum terminalis Denticulate ligament Conus medullaris Ventral median fissure Dorsal median sulcus Dorsal intermedian sulcus Dorsal lateral sulcus Central canal Posterior root ganglion Spinal nerve Dorsal horn and Ventral horn Anterior spinal artery 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. 30. Artery of Adamkiewicz Posterior spinal artery Anterior and Posterior radicular arteries Lissauer’s tract (dorsolateral fasciculus) Substantia gelatinosa--- Rexed’s laminae I-II Nucleus proprius--- laminae III-IV Doral column (Fasciculus gracilis and cuneatus) Clarke’s column (T1-L3)---Rexed’s laminae VII Spinothalamic tract (anterior and lateral) Fasciculus proprius Spinocerebellar tract (anterior and posterior) Rubospinal tract Corticospinal tract (lateral and ventral) Tectospinal tract Reticulospinal tract (lateral or medullary; medial or pontine) Vestibulospinal tract