* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download Supplementary information about the five
Genetic engineering wikipedia , lookup
Epigenetics of depression wikipedia , lookup
Ridge (biology) wikipedia , lookup
History of genetic engineering wikipedia , lookup
Epigenetics in learning and memory wikipedia , lookup
X-inactivation wikipedia , lookup
Neuronal ceroid lipofuscinosis wikipedia , lookup
Oncogenomics wikipedia , lookup
Epigenetics wikipedia , lookup
Transgenerational epigenetic inheritance wikipedia , lookup
Genome evolution wikipedia , lookup
Cancer epigenetics wikipedia , lookup
Genomic imprinting wikipedia , lookup
Long non-coding RNA wikipedia , lookup
Epigenetics in stem-cell differentiation wikipedia , lookup
Gene desert wikipedia , lookup
Gene therapy wikipedia , lookup
Genome (book) wikipedia , lookup
Gene nomenclature wikipedia , lookup
Behavioral epigenetics wikipedia , lookup
Polycomb Group Proteins and Cancer wikipedia , lookup
Vectors in gene therapy wikipedia , lookup
Epigenetics of human development wikipedia , lookup
Epigenetics of neurodegenerative diseases wikipedia , lookup
Microevolution wikipedia , lookup
Helitron (biology) wikipedia , lookup
Site-specific recombinase technology wikipedia , lookup
Epigenetics of diabetes Type 2 wikipedia , lookup
Therapeutic gene modulation wikipedia , lookup
Gene therapy of the human retina wikipedia , lookup
Mir-92 microRNA precursor family wikipedia , lookup
Designer baby wikipedia , lookup
Artificial gene synthesis wikipedia , lookup
Gene expression profiling wikipedia , lookup
Supplementary information about the five-gene model. Similar to the four-gene model, depending on the dominance between the positive and negative feedback of gene x1 , the five-gene model showed three behaviors: (i) fixed-point attractor with high expression of pluripotent genes (FP), (ii) fixed-point attractor with high expression of differentiation genes (FD), and (iii) the oscillatory state (O). The five-gene model also showed differentiation from the oscillatory state (Fig. S4). The attractor depended on the parameters Kij for each edge, while most effective regulations to determine the type of attractors were related to gene x1 , as in the four-gene model. In the five-gene model, the expression level of gene x5 was important because the key gene x1 is promoted via x5 . Where oscillatory gene expression was observed, the gene expression levels in each cell were desynchronized with cell division, and the epigenetic threshold variables took different values according to cells. With the change in epigenetic variables, oscillation was attenuated or terminated for some cells, leading to differentiation. 1