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BIOGRAPHICAL SKETCH
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NAME
POSITION TITLE
Koelle, Michael, R.
Associate Professor of Molecular Biophysics &
Biochemistry
eRA COMMONS USER NAME
MKOELLE
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
DEGREE
(if applicable)
YEAR(s)
FIELD OF STUDY
University of Washington, Seattle, WA
B.S., B.S.
1982-86
Biology, Math
Stanford University, Stanford, CA
Ph.D.
1986-92
Biochemistry
MIT, Cambridge, MA
Postdoctoral
1992-96
Molecular Genetics
A. Positions and Honors
Research and Professional Experience:
1986-1992 Ph.D. in Biochemistry, Laboratory of Dr. David S. Hogness, Stanford University
1992-1996 Postdoctoral Fellow, Laboratory of Dr. H. Robert Horvitz, MIT
1996-2001 Assistant Professor of Molecular Biophysics and Biochemistry, Yale University
2001-2005 Associate Professor of Molecular Biophysics and Biochemistry, Yale University
2005Tenured Associate Professor of Molecular Biophysics and Biochemistry, Yale University
Other Experience
2004
Co-organizer, East Coast C. elegans Meeting
2007-2008 Co-organizer, International RGS Protein Colloquium
Honors
1986-1989 National Science Foundation Predoctoral Fellowship
1992-1995 Helen Hay Whitney Foundation Postdoctoral Fellowship
1995-1996 Senior Postdoctoral Fellowship, The Medical Foundation
1997-2001 Pew Scholar
1999-2004 Leukemia Society Scholar
2001
Dylan Hixon Prize for Teaching Excellence in the Natural Sciences at Yale
B. Selected peer-reviewed publications (in chronological order)
Koelle, M.R., Talbot, W.S., Segraves, W.A., Bender, M.T., Cherbas, P. and Hogness, D.S. (1991)
The Drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid
receptor superfamily. Cell 67, 59-77.
Koelle, M. R., Segraves, W. A., and Hogness, D.S. (1992) DHR3: a Drosophila steroid receptor
homolog. Proc. Natl. Acad. Sci. USA. 89, 6167-6171.
Koelle, M.R., and Horvitz, H.R. (1996) egl-10 regulates G protein signaling in the C. elegans
nervous system and shares a conserved domain with many mammalian proteins. Cell 84, 115125.
Hajdu-Cronin, Y.M., Chen, W.J., Patikoglou, G., Koelle, M.R., Sternberg, P.W. (1999) Antagonism
between Go and Gq in Caenorhabditis elegans: the RGS protein EAT-16 is necessary for Go
signaling and regulates Gq activity. Genes Dev. 13, 1780-1793.
Dong, M.Q., Chase, D., Patikoglou, G.A., and Koelle, M.R. (2000). Multiple RGS proteins alter
neural G protein signaling to allow C. elegans to rapidly change behavior when fed. Genes
Dev. 14, 2003-2014.
Chase, D.L., Patikoglou, G.A, and Koelle, M.R. (2001). Two RGS proteins that inhibit Go and Gq
signaling in C. elegans neurons require a G5-like subunit for function. Curr. Biol. 11, 222-231.
Patikoglou, G.A. and Koelle, M.R. (2002). An N-terminal region of C. elegans RGS proteins EGL10 and EAT-16 directs inhibition of Go versus Gq signaling. J. Biol. Chem. 277, 47004-13.
Bany, I.A., Dong, M.Q., and Koelle, M.R. (2003). Genetic and cellular basis for acetylcholine
inhibition of Caenorhabditis elegans egg-laying behavior. J. Neurosci. 23, 8060-8069.
Moresco, J.J., and Koelle, M.R. (2004). Activation of EGL-47, a Go-coupled receptor, inhibits
function of HSN motor neurons to regulate Caenorhabditis elegans egg-laying behavior. J.
Neurosci., 24, 8522-8530.
Chase, D.L., Pepper, J.S., and Koelle, M.R. (2004). Mechanism of extrasynaptic dopamine
signaling in C. elegans. Nature Neurosci, 7, 1096-1103.
Hess, H.A., Röper J.C., Grill, S.W., and Koelle, M.R. (2004). RGS-7 Completes a ReceptorIndependent Heterotrimeric G Protein Cycle to Asymmetrically Regulate Mitotic Spindle
Positioning in C. elegans. Cell 119, 209-218.
Jose, A.M., and Koelle, M.R. (2005). Domains, amino acid residues, and new isoforms of C.
elegans diacylglycerol kinase DGK-1 important for terminating diacylglycerol signaling in
vivo. J. Biol. Chem. 280, 2730-2736.
Palmitessa, A., Hess, H.A., Bany, I.A., Kim, Y.M., Koelle, M.R., and Benovic, J.L. (2005).
Caenorhabditus elegans arrestin regulates neural G protein signaling and olfactory
adaptation and recovery. J. Biol. Chem. 280, 24649-24662.
Jose, A.M., Bany, I.A., Chase, D.L., and Koelle, M.R. (2007). A Specific Subset of TRPV Channel
Subunits in Caenorhabditis elegans Endocrine Cells Function as Mixed Heteromers to
Promote Neurotransmitter Release. Genetics 175, 93-105.
Ferkey, D.M, Hyde, R., Haspel, G., Dionne, H.M., Hess, H.A., Suzuki, H., Schafer, W.R., Koelle,
M.R., and Hart, A.C. (2007). C. elegans G Protein Regulator RGS-3 Controls Sensitivity to
Sensory Stimuli. Neuron 53, 39-52.
Tanis, J.E., Moresco, J.J., Lindquist, R.A., and Koelle, M.R. (2008). Regulation of serotonin
biosynthesis by the G proteins Go and Gq controls serotonin signaling in C. elegans.
Genetics 178, 157-169.
Tanis, J.E., Bellemer, A., Moresco, J.J., Forbush, B., and Koelle, M.R. (2009). The potassium
chloride cotransporter KCC-2 coordinates development of inhibitory neurotransmission and
synapse structure in C. elegans. J. Neurosci., in press.
Selected invited reviews and book chapters
Koelle, M.R. (1997) A new family of regulators of G-protein signaling - the RGS proteins. Cur. Op.
Cell Biol. 9, 143-147.
Koelle, M.R. (2001) C. elegans as a model for human biology and disease. In Genetic Models in
Cardiology. (Haddad, G.G. and Xu, T. eds.) Vol 156, pp. 21-34, Marcel Dekker, New York,
NY.
Chase, D.L., and Koelle, M.R. (2004). Genetic analysis of RGS protein function in Caenorhabditis
elegans. Methods Enz., 389, 305-320.
Hess, H.A., Reinke, V., and Koelle, M.R. (2006). Reverse genetics using targeted gene deletions
in C. elegans. WormBook, ed. The C. elegans Research Community, WormBook,
doi/10.1895/wormbook.1.47.1, http://www.wormbook.org.
Chase, D.L., and Koelle, M.R. (2006). Biogenic Amine Neurotransmitters in C. elegans. In
WormBook. ed. The C. elegans Research Community, WormBook,
doi/10.1895/wormbook.1.132.1, http://www.wormbook.org.
Koelle, M.R. (2006). G protein signaling moves inside the cell. Cell 126, 25-27.
Porter, M.Y., and Koelle, M.R. (2009). Insights into RGS protein function from studies in
Caenorhabditis elegans. Prog. in Mol. Biol. and Translational Sci., 86. in press.
C. Research Support
Ongoing Research Support
5R01 NS36918-09
Koelle (PI)
1/1/06-12/31/2010
NIH/NINDS
2.7 academic, 0.9 summer
G Protein Signaling in the C. elegans Nervous System
This project seeks to understand how neurotransmitters signal through G protein-coupled
receptors to modulate activities of neurons.
Role: PI
1R21MH082201-01A1
Koelle (PI)
7/1/2008-1/31/2010
NIH/NIMH
2.4 academic
Biochemical and genetic analysis of Regulator of G protein Signaling (RGS) proteins
This project seeks to analyze the protein complexes formed by RGS proteins to test a specific
hypothesis that they form an unconventional type of G protein heterotrimer.
Role: PI