* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download (Rev. 9/04), Biographical Sketch Format Page
Gene expression wikipedia , lookup
Index of biochemistry articles wikipedia , lookup
History of molecular evolution wikipedia , lookup
Ancestral sequence reconstruction wikipedia , lookup
Magnesium transporter wikipedia , lookup
Protein (nutrient) wikipedia , lookup
Molecular evolution wikipedia , lookup
Molecular neuroscience wikipedia , lookup
Biochemistry wikipedia , lookup
Secreted frizzled-related protein 1 wikipedia , lookup
Clinical neurochemistry wikipedia , lookup
Biochemical cascade wikipedia , lookup
Gene regulatory network wikipedia , lookup
Intrinsically disordered proteins wikipedia , lookup
Interactome wikipedia , lookup
Nuclear magnetic resonance spectroscopy of proteins wikipedia , lookup
Protein moonlighting wikipedia , lookup
Western blot wikipedia , lookup
List of types of proteins wikipedia , lookup
Signal transduction wikipedia , lookup
Protein adsorption wikipedia , lookup
BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FOUR PAGES. NAME POSITION TITLE Koelle, Michael, R. Associate Professor of Molecular Biophysics & Biochemistry eRA COMMONS USER NAME MKOELLE EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) INSTITUTION AND LOCATION DEGREE (if applicable) YEAR(s) FIELD OF STUDY University of Washington, Seattle, WA B.S., B.S. 1982-86 Biology, Math Stanford University, Stanford, CA Ph.D. 1986-92 Biochemistry MIT, Cambridge, MA Postdoctoral 1992-96 Molecular Genetics A. Positions and Honors Research and Professional Experience: 1986-1992 Ph.D. in Biochemistry, Laboratory of Dr. David S. Hogness, Stanford University 1992-1996 Postdoctoral Fellow, Laboratory of Dr. H. Robert Horvitz, MIT 1996-2001 Assistant Professor of Molecular Biophysics and Biochemistry, Yale University 2001-2005 Associate Professor of Molecular Biophysics and Biochemistry, Yale University 2005Tenured Associate Professor of Molecular Biophysics and Biochemistry, Yale University Other Experience 2004 Co-organizer, East Coast C. elegans Meeting 2007-2008 Co-organizer, International RGS Protein Colloquium Honors 1986-1989 National Science Foundation Predoctoral Fellowship 1992-1995 Helen Hay Whitney Foundation Postdoctoral Fellowship 1995-1996 Senior Postdoctoral Fellowship, The Medical Foundation 1997-2001 Pew Scholar 1999-2004 Leukemia Society Scholar 2001 Dylan Hixon Prize for Teaching Excellence in the Natural Sciences at Yale B. Selected peer-reviewed publications (in chronological order) Koelle, M.R., Talbot, W.S., Segraves, W.A., Bender, M.T., Cherbas, P. and Hogness, D.S. (1991) The Drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily. Cell 67, 59-77. Koelle, M. R., Segraves, W. A., and Hogness, D.S. (1992) DHR3: a Drosophila steroid receptor homolog. Proc. Natl. Acad. Sci. USA. 89, 6167-6171. Koelle, M.R., and Horvitz, H.R. (1996) egl-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins. Cell 84, 115125. Hajdu-Cronin, Y.M., Chen, W.J., Patikoglou, G., Koelle, M.R., Sternberg, P.W. (1999) Antagonism between Go and Gq in Caenorhabditis elegans: the RGS protein EAT-16 is necessary for Go signaling and regulates Gq activity. Genes Dev. 13, 1780-1793. Dong, M.Q., Chase, D., Patikoglou, G.A., and Koelle, M.R. (2000). Multiple RGS proteins alter neural G protein signaling to allow C. elegans to rapidly change behavior when fed. Genes Dev. 14, 2003-2014. Chase, D.L., Patikoglou, G.A, and Koelle, M.R. (2001). Two RGS proteins that inhibit Go and Gq signaling in C. elegans neurons require a G5-like subunit for function. Curr. Biol. 11, 222-231. Patikoglou, G.A. and Koelle, M.R. (2002). An N-terminal region of C. elegans RGS proteins EGL10 and EAT-16 directs inhibition of Go versus Gq signaling. J. Biol. Chem. 277, 47004-13. Bany, I.A., Dong, M.Q., and Koelle, M.R. (2003). Genetic and cellular basis for acetylcholine inhibition of Caenorhabditis elegans egg-laying behavior. J. Neurosci. 23, 8060-8069. Moresco, J.J., and Koelle, M.R. (2004). Activation of EGL-47, a Go-coupled receptor, inhibits function of HSN motor neurons to regulate Caenorhabditis elegans egg-laying behavior. J. Neurosci., 24, 8522-8530. Chase, D.L., Pepper, J.S., and Koelle, M.R. (2004). Mechanism of extrasynaptic dopamine signaling in C. elegans. Nature Neurosci, 7, 1096-1103. Hess, H.A., Röper J.C., Grill, S.W., and Koelle, M.R. (2004). RGS-7 Completes a ReceptorIndependent Heterotrimeric G Protein Cycle to Asymmetrically Regulate Mitotic Spindle Positioning in C. elegans. Cell 119, 209-218. Jose, A.M., and Koelle, M.R. (2005). Domains, amino acid residues, and new isoforms of C. elegans diacylglycerol kinase DGK-1 important for terminating diacylglycerol signaling in vivo. J. Biol. Chem. 280, 2730-2736. Palmitessa, A., Hess, H.A., Bany, I.A., Kim, Y.M., Koelle, M.R., and Benovic, J.L. (2005). Caenorhabditus elegans arrestin regulates neural G protein signaling and olfactory adaptation and recovery. J. Biol. Chem. 280, 24649-24662. Jose, A.M., Bany, I.A., Chase, D.L., and Koelle, M.R. (2007). A Specific Subset of TRPV Channel Subunits in Caenorhabditis elegans Endocrine Cells Function as Mixed Heteromers to Promote Neurotransmitter Release. Genetics 175, 93-105. Ferkey, D.M, Hyde, R., Haspel, G., Dionne, H.M., Hess, H.A., Suzuki, H., Schafer, W.R., Koelle, M.R., and Hart, A.C. (2007). C. elegans G Protein Regulator RGS-3 Controls Sensitivity to Sensory Stimuli. Neuron 53, 39-52. Tanis, J.E., Moresco, J.J., Lindquist, R.A., and Koelle, M.R. (2008). Regulation of serotonin biosynthesis by the G proteins Go and Gq controls serotonin signaling in C. elegans. Genetics 178, 157-169. Tanis, J.E., Bellemer, A., Moresco, J.J., Forbush, B., and Koelle, M.R. (2009). The potassium chloride cotransporter KCC-2 coordinates development of inhibitory neurotransmission and synapse structure in C. elegans. J. Neurosci., in press. Selected invited reviews and book chapters Koelle, M.R. (1997) A new family of regulators of G-protein signaling - the RGS proteins. Cur. Op. Cell Biol. 9, 143-147. Koelle, M.R. (2001) C. elegans as a model for human biology and disease. In Genetic Models in Cardiology. (Haddad, G.G. and Xu, T. eds.) Vol 156, pp. 21-34, Marcel Dekker, New York, NY. Chase, D.L., and Koelle, M.R. (2004). Genetic analysis of RGS protein function in Caenorhabditis elegans. Methods Enz., 389, 305-320. Hess, H.A., Reinke, V., and Koelle, M.R. (2006). Reverse genetics using targeted gene deletions in C. elegans. WormBook, ed. The C. elegans Research Community, WormBook, doi/10.1895/wormbook.1.47.1, http://www.wormbook.org. Chase, D.L., and Koelle, M.R. (2006). Biogenic Amine Neurotransmitters in C. elegans. In WormBook. ed. The C. elegans Research Community, WormBook, doi/10.1895/wormbook.1.132.1, http://www.wormbook.org. Koelle, M.R. (2006). G protein signaling moves inside the cell. Cell 126, 25-27. Porter, M.Y., and Koelle, M.R. (2009). Insights into RGS protein function from studies in Caenorhabditis elegans. Prog. in Mol. Biol. and Translational Sci., 86. in press. C. Research Support Ongoing Research Support 5R01 NS36918-09 Koelle (PI) 1/1/06-12/31/2010 NIH/NINDS 2.7 academic, 0.9 summer G Protein Signaling in the C. elegans Nervous System This project seeks to understand how neurotransmitters signal through G protein-coupled receptors to modulate activities of neurons. Role: PI 1R21MH082201-01A1 Koelle (PI) 7/1/2008-1/31/2010 NIH/NIMH 2.4 academic Biochemical and genetic analysis of Regulator of G protein Signaling (RGS) proteins This project seeks to analyze the protein complexes formed by RGS proteins to test a specific hypothesis that they form an unconventional type of G protein heterotrimer. Role: PI