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Transcript
Chapter 21
Methods: Model Systems I
6 September, 2006
Model Systems
• Phage / Virus: DNA replication, Recombination, Regulation
• Bacteria: Minimal Cell
• S. cerevisiae: Minimal Eukaryote
• C. elegans: Development
• Drosophila: Genetics
• Mouse: Mammal
Overview
• Saccharomyces cerevisiae makes an excellent model system for studying
eukaryotic processes, including the cell cycle.
• S. cerevisiae is genetically tractable, and is readily cultured.
• Caenorhabitis elegans is an ideal model system for studying
development.
• C. elegans is easy to grow both sexually and asexually, has a defined
number of cells, and many genetic tools.
• Drosophila melanogaster is well characterized genetically, easy to grow,
and is long-standing model system.
• Mus musculus is a mammal whose development and stem cells are
similar to humans, and has a relatively rapid life cycle.
S. cerevisiae
Bread, beer, and the cell
cycle.
C. elegans
C. elegans
Defined cell lineages are useful in studying cell death and tissue
induction.
Drosophila has a rapid life cycle.
The first genetic maps were constructed in Drosophila. The fly is
also useful in studying development.
Genetic mosaics permit the analysis of lethal mutations.
P-element transposition can create transgenic flies.
P-element Transformation
Mouse Development