Download Innate immunity

Faculty
of
Pharmacy
Teacher name:
Dr. Suha M. Abudoleh
First Term
2016-2017
Immunology and vaccination
‫علم المناعة و المطاعيم‬
Course #
Credit hours :
Prerequisite:
501417
3
501415+501416
Lecture time:
Office # 326
Lecture days:
Office hours:
Room:
Course Description:
This course is designed to offer essential information of basic immunology Including:
development of the immune system, innate and acquired immunity, immunoglobulin
structure, antigen-antibody reactions, the major histocompatibility complex reactions
and antigen presentation, T cell receptors (structure, selection), T cell activation and
effector functions, cytokines, phagocytic cell function, immune responses to infectious
organisms and tumors, autoimmune diseases, autoimmunity, allergies, and immune
deficiencies, and immunogenicity and vaccination. Also it will cover the
immunological disorders and future therapeutic to treating certain diseases by using
immunological components.
Course objectives:
At the end of this course the students should be:
 Understand the essential components of the immune system
 Differentiation between innate and acquired immunity
 Understand the kinetic reaction of the immune system against evading microbes
 Understand the concept of the self, non self recognition by the immune system.
 Maturation and differentiation of the T and B cells
 Understand the different types of vaccines and their clinical uses
 Understand some of the immunological disorders and their potential therapeutic
Course outline:
Topic
1.




2.
Overview of the immune system
Terminology and general properties
Components of the immune system
Damaging effects of the immune response
Future of the immunology
Innate immunity





3.




4.






5.
6.



Cellular receptors for microbes and damaged cells
Component of the innate immunity
Innate immune reactions
Microbe evasions of innate immunity
Role of innate immunity in stimulating adaptive immunity
Acquired immunity
Cells and organs involved in acquired immunity
Biology of B lymphocytes
Biology and learning of T lymphocytes
Interrelation between innate and acquired immunity
Immunogens and antigens
Requirements for immunogenicity
Primary and secondary immune responses
Antigenicity and antigen binding site
Epitopes recognized by B and T cells
Major classes of antigen
Cross-reactivity
Adjuvant and vaccines
Antibody structure and function
Structure of immunoglobulins
Biological properties of immunoglobulins
Kinetics of antibody responses following immunization;
primary and secondary responses.
7. Role of the MHC in the immune system
8.



Cytokines
General properties
Functional categories of cytokines
Roles of cytokines in diseases
Bacterial septic shock
Cancer
 Therapeutic exploitation of cytokines
Cytokines inhibitors
Treatment of immunodeficiency
Treatment of cancer and transplant patients
Treatment of allergies and asthma
9. Tolerance and autoimmunity
10. Hypersensitivity reactions
11. Congenital and acquired immunodeficiencies
References:
Basic immunology; functions and disorders of the Immune system. Fourth edition.
(2016) By Abbas Abul, Lichhtman Andrew and Pillai Shiv.
Immunology: A short course. (2015). Seventh edition By Richard Coico and Geoffrey
Sunshine
Immunology a short course. Sixth edition. By Coico Richard and Geoffrey Sunshine.
Microbiology and immunology. (2014). Sixth edition. By Hawley, Ziegler, and Clarke
Cellular and molecular immunology. Sixth edition. (2007). By Abbas Abul, Lichtman
Andrew, and Pillai Shiv
Attendance Policies:
 Be Punctual.
 Attendance is mandatory. Students are not allowed to miss more than 15%
of the lectures, without acceptable real cause.
 If a student misses more that 15 % of the course lectures, she/he will forfeit
the course credits. After this, medical reports may be submitted for
evaluation, for a total absence of no more than 20%. If student misses more
than 20% of lectures, regardless of the cause, the course will be failed.
In the lecture hall:
 Mobile phones must be turned off or muted in the lecture hall and they are
not allowed in the exams.
 The medical report should be presented within 72 hours after the end of
cause
Grading system:
First exam:
25%
Second exam: 25%
Course work: 10%
Final exam:
40%
Total
100