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Faculty of Pharmacy Teacher name: Dr. Suha M. Abudoleh First Term 2016-2017 Immunology and vaccination علم المناعة و المطاعيم Course # Credit hours : Prerequisite: 501417 3 501415+501416 Lecture time: Office # 326 Lecture days: Office hours: Room: Course Description: This course is designed to offer essential information of basic immunology Including: development of the immune system, innate and acquired immunity, immunoglobulin structure, antigen-antibody reactions, the major histocompatibility complex reactions and antigen presentation, T cell receptors (structure, selection), T cell activation and effector functions, cytokines, phagocytic cell function, immune responses to infectious organisms and tumors, autoimmune diseases, autoimmunity, allergies, and immune deficiencies, and immunogenicity and vaccination. Also it will cover the immunological disorders and future therapeutic to treating certain diseases by using immunological components. Course objectives: At the end of this course the students should be: Understand the essential components of the immune system Differentiation between innate and acquired immunity Understand the kinetic reaction of the immune system against evading microbes Understand the concept of the self, non self recognition by the immune system. Maturation and differentiation of the T and B cells Understand the different types of vaccines and their clinical uses Understand some of the immunological disorders and their potential therapeutic Course outline: Topic 1. 2. Overview of the immune system Terminology and general properties Components of the immune system Damaging effects of the immune response Future of the immunology Innate immunity 3. 4. 5. 6. Cellular receptors for microbes and damaged cells Component of the innate immunity Innate immune reactions Microbe evasions of innate immunity Role of innate immunity in stimulating adaptive immunity Acquired immunity Cells and organs involved in acquired immunity Biology of B lymphocytes Biology and learning of T lymphocytes Interrelation between innate and acquired immunity Immunogens and antigens Requirements for immunogenicity Primary and secondary immune responses Antigenicity and antigen binding site Epitopes recognized by B and T cells Major classes of antigen Cross-reactivity Adjuvant and vaccines Antibody structure and function Structure of immunoglobulins Biological properties of immunoglobulins Kinetics of antibody responses following immunization; primary and secondary responses. 7. Role of the MHC in the immune system 8. Cytokines General properties Functional categories of cytokines Roles of cytokines in diseases Bacterial septic shock Cancer Therapeutic exploitation of cytokines Cytokines inhibitors Treatment of immunodeficiency Treatment of cancer and transplant patients Treatment of allergies and asthma 9. Tolerance and autoimmunity 10. Hypersensitivity reactions 11. Congenital and acquired immunodeficiencies References: Basic immunology; functions and disorders of the Immune system. Fourth edition. (2016) By Abbas Abul, Lichhtman Andrew and Pillai Shiv. Immunology: A short course. (2015). Seventh edition By Richard Coico and Geoffrey Sunshine Immunology a short course. Sixth edition. By Coico Richard and Geoffrey Sunshine. Microbiology and immunology. (2014). Sixth edition. By Hawley, Ziegler, and Clarke Cellular and molecular immunology. Sixth edition. (2007). By Abbas Abul, Lichtman Andrew, and Pillai Shiv Attendance Policies: Be Punctual. Attendance is mandatory. Students are not allowed to miss more than 15% of the lectures, without acceptable real cause. If a student misses more that 15 % of the course lectures, she/he will forfeit the course credits. After this, medical reports may be submitted for evaluation, for a total absence of no more than 20%. If student misses more than 20% of lectures, regardless of the cause, the course will be failed. In the lecture hall: Mobile phones must be turned off or muted in the lecture hall and they are not allowed in the exams. The medical report should be presented within 72 hours after the end of cause Grading system: First exam: 25% Second exam: 25% Course work: 10% Final exam: 40% Total 100