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Transcript
The Three Stages of Catabolism Stage I: Hydrolysis of Macromolecules into Building Blocks FOOD Proteins Carbohydrates Amino Acids Monosaccharide Transamination Stage II: Conversion of Building Blocks into Acetyl CoA Fats Glycerol Fatty Acids Glycolysis Pyruvate Fatty Acid Spiral Acetyl CoA Citric Acid Cycle Stage III: Complete Oxidation forming simple End Products Oxidative Phosphorylation NH3 CO2 H2O Overview of Glucose Metabolism Carbons One 6C glucose SPLITS TO FORM two 3C molecules OXIDIZED TO FORM two 3C pyruvates BREAKING INTO two 1C CO 2 and CO2 two 2C Acetyl CoA High E n e rgy M o l ecu l e s Glucose Cytoplasm ATP Activation= -2 ATP Glyceraldehyde-3-phosphate NADH 2x1 = 2 NADH ATP 2x2 = 4 ATP Pyruvate NADH 2x1 = 2 NADH Acetyl CoA Mitochondrion FURTHER OXIDATION YIELDS a total of CO2 six 1C CO2 Oxygens O2 Oxygen receives H's from NADH and H2O FADH2 to form H2O. Citric Acid Cycle Oxidative Phosphorylation Total = C6H12O6 + 6 O2 —> 6 CO2 + 6 H2O NADH FADH 2 NADH 2x3 = 6 NADH 2x1 = 2 ATP ATP 2x1 = 2 FADH2 -10 NADH ATP FADH 2 -2 FADH 2 8x3 = 28 ATP 2x2 2x2 = 4 ATP Total 36ADP + 36Pi= 36 ATP
