Download Metabolism Stages Figure

The Three Stages of Catabolism
Stage I:
Hydrolysis of
Macromolecules
into Building Blocks
FOOD
Proteins
Carbohydrates
Amino Acids
Monosaccharide
Transamination
Stage II:
Conversion of
Building Blocks
into Acetyl CoA
Fats
Glycerol
Fatty Acids
Glycolysis
Pyruvate
Fatty
Acid
Spiral
Acetyl CoA
Citric
Acid
Cycle
Stage III:
Complete Oxidation
forming simple
End Products
Oxidative Phosphorylation
NH3
CO2
H2O
Overview of Glucose Metabolism
Carbons
One 6C glucose
SPLITS TO FORM
two 3C molecules
OXIDIZED TO FORM
two 3C pyruvates
BREAKING INTO
two 1C CO 2 and CO2
two 2C Acetyl CoA
High
E n e rgy
M o l ecu l e s
Glucose
Cytoplasm
ATP Activation= -2 ATP
Glyceraldehyde-3-phosphate
NADH
2x1 = 2 NADH
ATP
2x2 = 4 ATP
Pyruvate
NADH
2x1 = 2 NADH
Acetyl CoA
Mitochondrion
FURTHER OXIDATION
YIELDS a total of CO2
six 1C CO2
Oxygens
O2
Oxygen receives
H's from NADH and H2O
FADH2 to form H2O.
Citric
Acid
Cycle
Oxidative
Phosphorylation
Total = C6H12O6 + 6 O2 —> 6 CO2 + 6 H2O
NADH
FADH 2
NADH
2x3 = 6 NADH
2x1 = 2 ATP
ATP
2x1 = 2 FADH2
-10 NADH
ATP
FADH 2
-2 FADH 2
8x3 = 28 ATP
2x2
2x2 = 4 ATP
Total 36ADP + 36Pi= 36 ATP