Midazolam Oxidation by Cytochrome P450 3A4 and Active
... The oxidation of MDZ by CYP3A4 has been the focus of
many in vitro investigations (Kronbach et al., 1989; Gorski et
al., 1994; Ghosal et al., 1996; Maenpaa et al., 1998; Hosea et
al., 2000; Wang et al., 2000). These studies have found very
different KM values for the formation of 1⬘-OH MDZ compared ...