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Neurologic System The nervous system Central and peripheral divisions Maintains and controls all body functions by its voluntary and autonomic responses Neurologic System (Cont.) The physical examination of the nervous system assesses the following elements: Motor Sensory Autonomic Cognitive Behavioral Physical Examination Preview Neurologic System Test cranial nerves I through XII Cerebellar function and proprioception Evaluate coordination and fine motor skills by the following: Rapid rhythmic alternating movements Accuracy of upper and lower extremity movements Evaluate balance using the Romberg test Observe the patient’s gait Posture Rhythm and sequence of stride and arm movements Neurologic System (Cont.) Sensory function Test primary sensory responses to the following: Superficial touch Superficial pain Test vibratory response to tuning fork over joints or bony prominences on upper and lower extremities. Evaluate perception of position sense with movement of the great toes or a finger on each hand. Neurologic System (Cont.) Sensory function Assess ability to identify a familiar object by touch and manipulation. Assess two-point discrimination. Assess ability to identify a letter or number “drawn” on palm of hand. Assess ability to identify a body area when touched. Neurologic System (Cont.) Superficial and deep tendon reflexes Test abdominal reflexes. Test the cremasteric reflex in male patients. Test the plantar reflex. Test the following deep tendon reflexes: biceps, brachioradialis, triceps, patellar, and Achilles. Test for ankle clonus. Anatomy and Physiology Central nervous system Main network of coordination and control for the body Brain Spinal cord Peripheral nervous system Carries information to and from the central nervous system Cranial nerves Spinal nerves Anatomy and Physiology (Cont.) Autonomic nervous system Coordinates and regulates the internal organs of the body Two divisions that balance the impulses of each other Sympathetic division: prods body to action during periods of physiologic and psychologic stress Parasympathetic division: functions in a complementary and counterbalancing manner to conserve body resources and day-to-day functions (e.g., digestion and eliminations) Anatomy and Physiology (Cont.) Brain and spinal cord are protected by: Skull and vertebrae Meninges Cerebrospinal fluid (CSF) Three layers of meninges produce and drain CSF. CSF circulates between an interconnecting system of ventricles in the brain and around the brain and spinal cord, serving as a shock absorber. Anatomy and Physiology (Cont.) The intricate interrelationship of the nervous system permits the body to perform the following: Receive sensory stimuli from the environment Identify and integrate the adaptive processes needed to maintain current body functions Orchestrate body function changes required for adaptation and survival Integrate the rapid responsiveness of the central nervous system with the more gradual responsiveness of the endocrine system Control cognitive and voluntary behavioral processes Control subconscious and involuntary body functions Brain Blood supply 20% of cardiac output Arterial Two internal carotids Two vertebral Venous Venous plexuses and dural sinuses Two internal jugular veins Brain (Cont.) Three major units Cerebrum Cerebellum Brainstem Cerebrum Two cerebral hemispheres, each divided into lobes, form the cerebrum. Gray outer layer (cerebral cortex) houses the higher mental functions and is responsible for: General movement Visceral functions Perception Behavior Integration of functions Cerebrum (Cont.) Commissural fibers (corpus callosum) interconnect the counterpart areas in each hemisphere, permitting the coordination of activities between the hemispheres. Cerebrum (Cont.) Frontal lobe Voluntary skeletal movement Fine repetitive movement Control of eye movement Corticospinal tracts extend from the primary motor area into the spinal cord. Cerebrum (Cont.) Parietal lobe Processes sensory data Interpretation of tactile sensations (i.e., temperature, pressure, pain, size, shape, texture, and two-point discrimination) Recognition of body parts and awareness of body position (proprioception) Cerebrum (Cont.) Parietal lobe Assists with: Visual sensations Gustatory sensations Olfactory sensations Auditory sensations Association fibers provide communication between the sensory and motor areas of the brain Cerebrum (Cont.) Occipital lobe Contains the primary vision center and provides interpretation of visual data Temporal lobe Perception and interpretation of sounds and determination of their source Integration of taste, smell, and balance Reception of speech and interpretation of speech located in Wernicke area Cerebrum (Cont.) Basal ganglia system Extrapyramidal pathway and processing station between the cerebral motor cortex and the upper brainstem Refine motor movements through interconnections with: Thalamus Motor cortex Reticular formation Spinal cord Cerebrum (Cont.) Aids in integration of voluntary movement to produce steady and precise movements Processes sensory information Eyes, ears, touch receptors, and musculoskeleton Uses sensory data for reflexive control of: Muscle tone Equilibrium Posture Brainstem Pathway between the cerebral cortex and the spinal cord Controls many involuntary functions The nuclei of the 12 cranial nerves arise from these structures Brainstem (Cont.) Parts Medulla oblongata Site where the descending corticospinal tracts decussate (cross to the contralateral side) Midbrain Pons Transmits information between the brainstem and the cerebellum Diencephalon Thalamus: major integrating center for perception of various sensations Cranial Nerves Twelve peripheral nerves that originate from brain Functions Motor Sensory Parasympathetic Spinal Cord and Spinal Tracts Spinal cord Spinal cord begins as a continuation of medulla oblongata. Fibers grouped into tracts run through spinal cord and carry sensory, motor, and autonomic impulses between higher centers and the body. Myelin-coated white matter contains ascending and descending tracts. Gray matter contains nerve cell bodies. Spinal Cord and Spinal Tracts (Cont.) Ascending spinal tracts: spinothalamic, spinocerebellar Mediate sensations Facilitate signals for complex discriminations tasks Transmit precise information on types of stimulus and location Spinal Cord and Spinal Tracts (Cont.) Ascending spinal tracts Posterior (dorsal) column tract: fasciculus gracilis, fasciculus cuneatus Carries the fibers for the sensations of fine touch, two-point discrimination, and proprioception Spinothalamic tracts carry fibers for sensations of light and crude touch, pressure, temperature, and pain. Spinal Cord and Spinal Tracts (Cont.) Descending spinal tracts: corticospinal, reticulospinal, and vestibulospinal Originate in the brain Convey inhibitory or facilitatory impulses to various muscle groups Play a role in the control of: Muscle tone Posture Precise motor movements Spinal Cord and Spinal Tracts (Cont.) Descending spinal tracts Corticospinal tract permits skilled, delicate, and purposeful movements. Vestibulospinal tract causes extensor muscles to contract suddenly when falling. Corticobulbar tract innervates the motor functions of the cranial nerves. Spinal Cord and Spinal Tracts (Cont.) Upper motor neurons Nerve cell bodies for the motor pathways that all originate and terminate within the central nervous system Comprise descending pathways from brain to spinal cord Primary role is influencing, directing, and modifying spinal reflex arcs and circuits Can affect movement only through the lower motor neurons Injury results in initial paralysis followed by partial recovery over an extended period Spinal Cord and Spinal Tracts (Cont.) Lower motor neurons Cranial and spinal: originate in the anterior horn of spinal cord and extend into peripheral nervous system Transmit neural signals directly to the muscles to permit movement Injury often results in permanent paralysis Spinal Nerves Thirty-one pairs arise from the spinal cord Exit at each intervertebral foramen Sensory and motor fibers of each spinal nerve supply receive information in a specific body distribution called a dermatome Spinal Nerves (Cont.) Within the spinal cord, each spinal nerve separates into anterior and posterior roots. Motor or efferent fibers of the anterior root carry impulses from the spinal cord to the muscles and glands of the body. Sensory or afferent fibers of the posterior root carry impulses from sensory receptors of the body to the spinal cord, and then on to the brain for interpretation by the cerebral sensory cortex. Spinal Nerves (Cont.) Reflex arcs Spinal afferent (sensory) neuron may initiate a reflex arc response when it receives an impulse stimulus. Response is transmitted outward by the efferent (motor) neuron in the anterior horn of the spinal cord via the spinal nerve and peripheral nerve of the skeletal muscle. Spinal Nerves (Cont.) Reflex arcs (Cont.) Dependent on: Intact afferent neurons Functional synapses in the spinal cord Intact efferent neurons Functional neuromuscular junctions Competent muscle fibers Infants and Children Major brain growth and myelinization in first year of life At birth, the neurologic impulses primarily handled by the brainstem and spinal cord Sucking, rooting, yawn, sneeze, hiccup, blink at bright light, and withdrawal from painful stimuli Infants and Children (Cont.) Primitive reflexes present in newborn Moro (startle reflex), stepping, palmar and plantar grasp Motor maturation in cephalocaudal direction Head and neck Trunk Extremities Brain growth continues until 12 to 15 years of age Pregnant Women Hypothalamic-pituitary neurohormonal changes occur with pregnancy Specific alterations in the neurologic system are not well identified. Common alterations Increase nap and sleep time Do not feel rested after sleep Leg cramps and restless leg syndrome Older Adults The number of cerebral neurons decreases with aging, but this is not necessarily associated with deteriorating mental function. Vast number of reserve neurons inhibits the appearance of clinical signs. Velocity of nerve impulse conduction declines. Slowed response time Diminished touch and pain perception Review of Related History History of Present Illness Seizures or convulsions Sequence of events Character of symptoms Aura Level of consciousness Automatism: eyelid fluttering, chewing, lip smacking, swallowing History of Present Illness (Cont.) Seizures or convulsions (Cont.) Muscle tone Postictal phase behavior Relationship of seizure to other events Frequency of seizures Medication: anticonvulsant; initiation of medication that interacts with prescribed anticonvulsant History of Present Illness (Cont.) Pain Onset: sudden or progressive Quality Location Associated manifestations Efforts to treat Medications: opioids and NSAIDs; prescription, nonprescription History of Present Illness (Cont.) Gait coordination Balance Falling Associated problems: arthritis, stroke, seizure Medications: phenytoin, pyrimethamine, etoposide, vinblastine; prescription, nonprescription History of Present Illness (Cont.) Weakness or paresthesia Onset Character: generalized or specific body area Associated symptoms Concurrent chronic illness: HIV, nutritional or vitamin deficiency Medications: zidovudine, diaminodiphenylsulfone, dideoxyinosine, amphotericin B History of Present Illness (Cont.) Tremor Onset: sudden or gradual Character: worse with rest, intentional movement Associated problems: hyperthyroidism, familial tremor, liver or kidney disorder, consumption of alcohol, multiple sclerosis Relieved by: rest, activity, alcohol Medications: neuroleptics, valproate, phenytoin, albuterol, pseudoephedrine, antiarrhythmics, corticosteroids, caffeine Past Medical History Trauma: brain, spinal cord, or localized injury Meningitis, encephalitis, lead poisoning, poliomyelitis Deformities, congenital anomalies, genetic syndromes Cardiovascular or circulatory problem Neurologic disorder, brain surgery, and residual effects Family History Hereditary disease Alcoholism Mental retardation Epilepsy, seizure disorder, or headaches Alzheimer disease or other dementia Learning disorders Weakness or gait disorders Medical or metabolic disorder Personal and Social History Environmental or occupational hazards Hand, eye, foot dominance, family patterns of dexterity and dominance Ability to care for self Sleeping and eating patterns Use of alcohol and drugs Infants Prenatal history Birth history Respiratory status at birth Neonatal health Congenital anomalies Hypotonia or hypertonia in infancy, developmental delay Children Developmental milestones Age attained Pattern of development Performance of self-care activities: dressing, toileting, feeding Hyperactive or impulsive behavior Health problems Headaches, seizures, clumsiness or unsteady gait, muscle weakness or falling Pregnant Women Weeks of gestation or estimated date of delivery Seizure activity: past history of seizures or pregnancy-induced hypertension; frequency, duration, character of movement Headache Nutritional status Older Adults Pattern of increased stumbling, falls, unsteadiness, or decreased agility Interference with performance of ADLs, social withdrawal, feelings about symptoms Hearing loss, vision deficit, or anosmia Fecal or urinary incontinence Transient neurologic deficits May indicate transient ischemic attacks (TIAs) Examination and Findings Neurologic Examination Components Cranial nerves Proprioception and cerebellar function Sensory function Reflex function Cranial Nerves Olfactory (CN I) Sensory and smell Test for odor identification Cranial Nerves (Cont.) Optic (CN II) sensory and visual acuity Test for visual acuity Test visual fields Perform ophthalmologic examination Cranial Nerves (Cont.) Oculomotor, trochlear, and abducens (CN III, IV, and VI): motor and eye movement, pupil size, eyelid opening Inspect eyelids for drooping. Inspect pupils for size and equality. Test consensual response and accommodation. Test extraocular eye movements. Cranial Nerves (Cont.) Trigeminal (CN V) Mixed: muscle tone and sensation Inspect face for atrophy or tremors. Palpate jaw for tone and strength. Test for pain and sensation. Test corneal reflex. Cranial Nerves (Cont.) Facial (CN VII) Mixed: facial expressions and taste Inspect facial symmetry. Test tongue for salt and sweet. Cranial Nerves (Cont.) Acoustic (CN VIII): sensory, hearing, and balance Test hearing. Compare bone and air conduction. Test for sound lateralization. Cranial Nerves (Cont.) Glossopharyngeal (CN IX); Mixed: taste and swallowing Test tongue for sour and bitter. Test gag reflex and swallow. Cranial Nerves (Cont.) Vagus (CN X); Mixed: swallowing and speech Inspect palate and uvula for symmetry. Inspect for swallow difficulty. Evaluate guttural speech sounds. Spinal accessory (CN XI): motor and muscle strength Test trapezius and sternocleidomastoid muscle strength. Cranial Nerves (Cont.) Hypoglossal (CN XII): motor and tongue strength Inspect tongue for symmetry/tremors/atrophy. Test tongue movement. Test tongue strength. Evaluate lingual speech sounds. Proprioception and Cerebellar Function Coordination and fine motor skills Observe for any involuntary movements, such as tremors (rhythmic oscillatory involuntary movements), tics, or fasciculations. Note the parts of the body affected, quality, rate and rhythm. Proprioception and Cerebellar Function (Cont.) Coordination and fine motor skills (Cont.) Test rapid rhythmic alternating movements: Alternately turning up and down the palms of the hands Touching thumb-to-fingers Test accuracy of movements: Finger-to-finger test Finger-to-nose Heel-to-shin Proprioception and Cerebellar Function (Cont.) Balance Equilibrium Romberg test Standing on one foot Gait Observe the expected gait sequence, noting simultaneous arm movements and upright posture Heel-toe walking Sensory Function Test with the patient’s eyes closed. Observe all sensory function tests for: Side-to-side differences Interpretation of sensation Discrimination Location If impairments are found, map boundaries by dermatome. Evaluate both primary and cortical discriminatory sensation. Sensory Function (Cont.) Primary sensory functions Superficial touch Cotton wisp or fingertip Superficial pain Broken tongue blade or the point and hub of a sterile needle Temperature and deep pressure Tested only when superficial pain sensation is not intact Sensory Function (Cont.) Primary sensory functions (Cont.) Vibration Tuning fork (lower Hz) Position of joints Raise or lower Sensory Function (Cont.) Cortical sensory function Test cognitive ability to interpret sensations. Inability to perform these tests should make you suspect a lesion in: Sensory cortex Posterior columns of the spinal cord Sensory Function (Cont.) Cortical sensory function (Cont.) Stereognosis Familiar object (key, coin) Tactile agnosia, an inability to recognize objects by touch, suggests parietal lobe lesion Two-point discrimination Distance at which the patient can no longer distinguish two points Varies with body parts Sensory Function (Cont.) Cortical sensory function (Cont.) Extinction phenomenon Simultaneously touch two areas on each side of the body. Similar sensations should be felt bilaterally. Graphesthesia Draw a letter, number, or shape on the palm of the patient’s hand. Point location Touch an area on the patient’s skin and withdraw the stimulus. Reflexes Both superficial and deep tendon reflexes are used to evaluate the function of specific spine segmental levels. Reflexes (Cont.) Superficial reflexes Abdominal reflex Equal movement of umbilicus May be absent on the side of a corticospinal tract lesion, but their presence or absence may have little clinical significance Reflexes (Cont.) Superficial reflexes (Cont.) Cremasteric reflex Stroke the inner thigh of the male patient. Testicle and scrotum should rise on the stroked side. Reflexes (Cont.) Superficial reflexes (Cont.) Plantar reflex Stroke the lateral side of the foot from the heel to the ball and then curve across the ball of the foot to the medial side. Patient should have plantarflexion of all toes. Babinski sign is present when there is dorsiflexion of the great toe. Indicates pyramidal tract disease Reflexes (Cont.) Deep tendon reflexes Biceps: elbow flexion Brachioradial: forearm pronation and elbow flexion Triceps: elbow extension Patellar: lower leg extension Achilles: foot flexion Clonus: rhythmic oscillating movements Ankle Associated with upper motor neuron disease Reflexes (Cont.) Deep tendon reflexes (Cont.) Symmetric visible or palpable responses should be noted. Scoring deep tendon reflexes: 0 No response 1 Sluggish or diminished 2 Active or expected response 3 More brisk than expected, slightly hyperactive 4 Brisk, hyperactive, with intermittent or transient clonus Deep Tendon Reflexes Additional Procedures Protective sensation Test for protective sensation on several sites of the foot in all patients with diabetes mellitus and peripheral neuropathy Use the 5.07 monofilament or Waardenberg wheel Loss of protective pain sensation that alerts patients to skin breakdown and injury Additional Procedures (Cont.) Meningeal signs Stiff neck or nuchal rigidity is a sign that may be associated with meningitis and intracranial hemorrhage. With the patient supine, slip your hand under the head and raise it, flexing the neck. Pain and a resistance to neck motion are associated with nuchal rigidity. Additional Procedures (Cont.) Meningeal signs (Cont.) Brudzinski May also be present when neck stiffness is assessed May indicate meningeal irritation Involuntary flexion of the hips and knees when flexing the neck is a positive Brudzinski sign. Additional Procedures (Cont.) Meningeal signs (Cont.) Kernig May indicate meningeal irritation Evaluated by flexing the leg at the knee and hip when the patient is supine, then attempting to straighten the leg Pain in the lower back and resistance to straightening the leg at the knee constitute positive Kernig sign Brudzinski and Kernig Signs Infants Cranial nerves indirectly assessed by observing: CN II, III, IV, and VI Optical blink reflex Gaze and tracking Doll’s eye CN V Rooting Sucking Infants (Cont.) Cranial nerves CN VII Facial expressions Forehead wrinkling Smile CN VIII Acoustic blink reflex Doll’s eye maneuver Infants (Cont.) Cranial nerves CN IX and X Swallow and gag reflex CN XII Sucking and swallowing ability Tongue position with pinch test Infants (Cont.) Observe the infant’s spontaneous activity for symmetry and smoothness of movement. Coordinated sucking and swallowing is also a function of the cerebellum. A withdrawal of all limbs from a painful stimulus provides a measure of sensory integrity. The patellar tendon reflexes are present at birth, and the Achilles and brachioradial tendon reflexes appear at 6 months of age. Infants (Cont.) Posture and movement are routinely evaluated by primitive reflexes: Palmar grasp (birth) Plantar grasp (birth) Moro (birth) Placing (4 days of age) Stepping (between birth and 8 weeks) Asymmetric tonic neck (by 2 to 3 months) Inspect and palpate muscle for strength and tone. Children Observe neuromuscular development progress and skills displayed during physical examination. Evaluate developmental level. Modify CN examination according to age. Observe at play: Gait and fine motor coordination Heel-to-toe walking, hopping, jumping Children (Cont.) Deep tendon reflexes are not always tested in a child who demonstrates appropriate development. Evaluate light touch sensation by asking the child to close his or her eyes and point to where you touch or tickle. Use the tuning fork to evaluate vibration sensation. Superficial pain sensation is not routinely tested in young children. Pregnant Women Same as for adult Deep tendon reflexes on initial examination can serve as baseline Older Adults Same as for adult Medications can impair CNS function: Slowed reaction time, tremors, and anxiety Test gait for decreases in speed, balance, and grace Check tactile and vibratory sense for impairment Check deep tendon reflexes for diminished response Abnormalities Abnormalities Disorders of the central and peripheral nervous systems often fall into groups. Static problems develop at any age and do not get better or worse (e.g., nerve deafness and some trauma). Degenerative problems occur when function is lost and it progressively worsens. Some problems are intermittent, whereas others are genetic or related to a metabolic disorder. Central Nervous System Multiple sclerosis Progressive autoimmune disorder characterized by a combination of inflammation and degeneration of the myelin of the brain’s white matter leading to decreased brain mass and obstructed transmission of nerve impulses Gradual, but unpredictable, progression, with or without remissions Central Nervous System (Cont.) Seizure disorder Episodic abnormal electrical discharges (excessive concurrent firing) of cerebral neurons may be caused by: Central nervous system (CNS) disorder CNS structural defect Disorder that affects functioning of the CNS Examples include brain injury, toxins, stroke, brain tumor, or hypoxic syndromes Central Nervous System (Cont.) Encephalitis Acute inflammation of the brain and spinal cord, involving the meninges, often due to a virus such as herpes simplex virus Meningitis Inflammatory process in the meninges, the membrane around the brain and spinal cord Intracranial tumors Abnormal growth of neural or nonneural tissue within the cranial cavity that may be a primary or metastatic cancer Central Nervous System (Cont.) Stoke (brain attack or cerebrovascular accident) Sudden interruption of blood supply to a part of the brain or the rupture of a blood vessel, spilling blood into spaces around brain cells Ischemic Hemorrhagic Peripheral Nervous System Myasthenia gravis Autoimmune disorder of neuromuscular transmission Guillain-Barré syndrome Autoimmune-mediated destruction of peripheral nerve myelin sheaths and inflammation of nerve roots Occurs following a nonspecific gastrointestinal or upper respiratory infection 1 to 3 weeks earlier or following an immunization Peripheral Nervous System (Cont.) Trigeminal neuralgia (tic douloureux) Recurrent paroxysmal sharp pain that radiates into one or more branches of the fifth cranial nerve Bell palsy Temporary acute paralysis or weakness of one side of the face Peripheral Nervous System (Cont.) Peripheral neuropathy Disorder of the peripheral nervous system that results in motor and sensory loss in the distribution of one or more nerves Diabetes mellitus B12 or folate deficiency Lyme disease HIV infection Children Cerebral palsy Permanent disorder of movement and posture development Myelomeningocele (spina bifida) Congenital defect of one or more vertebrae (commonly the lumbar or sacral) that permits a meningeal sac filled with a portion of the spinal cord to protrude Children (Cont.) Shaken baby syndrome Severe form of child abuse resulting from the violent shaking of infants under 1 year of age Stretching and tearing of nerve tissue and blood vessels causes brain damage and a subdural hematoma Spinal cord may also be damaged Pregnant Women Intrapartum maternal lumbosacral plexopathy Neuropathy that can occur during late pregnancy and delivery Lumbosacral trunk, and sometimes the superior gluteal and obturator nerves, is compressed between the maternal pelvic rim and the fetal head (a conduction nerve block) Motor deficits in a lower extremity Older Adults Parkinson disease Slowly progressive, degenerative neurologic disorder Deficiency of the dopamine neurotransmitter results in poor communication between parts of the brain that coordinate and control movement and balance Older Adults (Cont.) Normal-pressure hydrocephalus Syndrome simulating degenerative diseases that is caused by noncommunicating hydrocephalus Postpolio syndrome Reappearance of neurologic signs in survivors of the polio epidemics Question 1 Testing for sharp, dull and light touch on the face at the scalp cheek and chin examines: A. CN V B. CN VI C. CN VII D. CN VIII Question 2 Nerves that arise from the brain rather than the spinal cord are called: A. Cranial B. Parasympathetic C. Sympathetic D. Lower motor neurons Question 3 Cerebellar ataxia or vestibular dysfunction is tested by: A. Testing the acoustic nerve B. Heel toe walking C. Finger to nose movement D. Romberg test Question 4 A neurologic past medical history should include data about: A. Family patterns of dexterity and dominance B. Circulatory problems C. Educational level D. Immunizations Question 5 Hyperactive reflexes indicate: A. Lower motor neuron disorder B. Upper motor neuron disorder C. Lower sensory neuron disorder D. Upper sensory neuron disorder Case Study Julie is a 38-year-old patient who presents acutely to your office for a concern regarding facial drooping. You diagnose her with Bell palsy. Which of the following is the etiology of the disorder? A. Bilateral inflammation of CN V B. Acute inflammation of CN V C. Acute inflammation of CN VII D. Chronic inflammation of CN VII Case Study (Cont.) On examination, which of the following would you expect to find? (Select all that apply). A. Drooping of the eyelid on the affected side B. Facial creases and nasolabial fold disappear on the affected side C. Absent facial sensation D. Absent cranial nerves III, IV, and VI Case Study (Cont.) In Bell palsy, you will expect to find: A. Lower motor neuron disorder B. Upper motor neuron disorder C. Lower sensory neuron disorder D. Upper sensory neuron disorder