* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download Slide 1 - AccessPharmacy
Histone acetylation and deacetylation wikipedia , lookup
Secreted frizzled-related protein 1 wikipedia , lookup
Genome evolution wikipedia , lookup
Deoxyribozyme wikipedia , lookup
RNA interference wikipedia , lookup
Gene desert wikipedia , lookup
Transcription factor wikipedia , lookup
Polyadenylation wikipedia , lookup
Gene expression profiling wikipedia , lookup
Molecular evolution wikipedia , lookup
RNA silencing wikipedia , lookup
Messenger RNA wikipedia , lookup
Epitranscriptome wikipedia , lookup
Artificial gene synthesis wikipedia , lookup
Expression vector wikipedia , lookup
Non-coding DNA wikipedia , lookup
Gene regulatory network wikipedia , lookup
Non-coding RNA wikipedia , lookup
RNA polymerase II holoenzyme wikipedia , lookup
Gene expression wikipedia , lookup
Eukaryotic transcription wikipedia , lookup
Promoter (genetics) wikipedia , lookup
Schematic diagram showing the transcription control regions in a hypothetical mRNA-producing, eukaryotic gene transcribed by RNA polymerase II. Such a gene can be divided into its coding and regulatory regions, as defined by the transcription start site (arrow; +1). The coding region contains the DNA sequence that is transcribed into mRNA, which is ultimately translated into protein. The regulatory region consists of 2 classes of elements. One class is responsible for ensuring basal expression. The “promoter,” is often composed of the TATA box and/or INR and/or DPE elements direct RNA polymerase II to the correct site (fidelity). However, in certain genes that lack TATA, the so-called TATA-less promoters, an initiator (INR) and/or DPE elements may direct the polymerase to this site. Another component, the upstream elements, specifies the frequency of initiation; such elements can either be proximal Source: Transcription: RNA Synthesis, Processing, and Regulation, Integrative Medical Biochemistry Examination and Board Review (50–200 bp) or distal (1000–105 bp) to the promoter as shown. Among the best studied of the proximal elements is the CAAT box, but several other Citation: King MW. Integrative Medical Examination and Board Review; 2014 Available at: http://mhmedical.com/ Accessed: May elements (bound by the transactivator proteins Sp1,Biochemistry NF1, AP1, etc) may be used in various genes. The distal elements enhance or repress expression, 06, 2017 several of which mediate the response to various signals, including hormones, heat shock, heavy metals, and chemicals. Tissue-specific expression also Copyright © 2017ofMcGraw-Hill Education. All dependence rights reserved involves specific sequences this sort. The orientation of all the elements is indicated by the arrows within the boxes. For example, the proximal promoter elements (TATA box, INR, DPE) must be in the 5′–3′ orientation, while the proximal upstream elements often work best in the 5′–3′