Download Essential Bio 4.1

Essential Biology 4.1 Chromosomes, Genes, Alleles, Mutations
Due Date:
Student Name:
Candidate Number: 002171-
Blog resource: http://tinyurl.com/5v54w9z
Click4Biology: http://click4biology.info/c4b/4/gene4.htm
Cite all sources using the CSE method (or ISO 690 Numerical in Word. Highlight all objective 1 command terms in
yellow and complete these before class. Highlight all objective 2 and 3 command terms in green – these will be
part of the discussions in class. After class, go back and review them.
Complete the self-assessment rubric before submitting to Moodle. Avoid printing this if possible.
1. Define the following:
Chromosome
Gene
Allele
Gene locus
Genome
Chromatid
Mutation
Haploid
Diploid
2. State the components of a chromosome.
 DNA &
3. State the number of chromosomes present in a single human diploid cell.

4. Identify structures a. and b. on the line drawing of a chromosome in
prophase shown to the right.
a.
b.
5. Give two examples of genes and some of their possible alleles.
Gene
Eye colour
Possible alleles
Blue, brown, green, hazel
6. List factors that increase the chance of a genetic mutation.


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Stephen Taylor
Bandung International School
http://sciencevideos.wordpress.com
Essential Biology 4.1 Chromosomes, Genes, Alleles, Mutations
Due Date:
Student Name:
Candidate Number: 002171-
7.
mRNA
amino acid
8. Distinguish between the two DNA strands above in terms of:
a. DNA base sequence.

b. Amino acid sequence in the resulting polypeptide.

9. Compare the following types of base-substitution mutation.
Silent mutation
Number of bases
substituted
Mis-sense mutation
1
Stop codon produced
early – polypeptide
shortened
Effect on polypeptide
Example illness
Stephen Taylor
Nonsense mutation
Sickle cell disease
Bandung International School
http://sciencevideos.wordpress.com
Essential Biology 4.1 Chromosomes, Genes, Alleles, Mutations
Due Date:
Student Name:
Candidate Number: 002171-
10. Describe the effects of sickle cell disease on sufferers in terms of:
a. Hemoglobin production

b. Symptoms and mortality

11. Identify parts of the world where a single sickle cell (Hbs) allele could be beneficial

Explain your answer

12. Define evolution.

13. Outline how mutations lead to evolution by natural selection.


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14. Outline how the spread of the sickle cell gene is an example of natural selection in action.
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15. How could this be an example of a correlation which has a strong element of causality?

Stephen Taylor
Bandung International School
http://sciencevideos.wordpress.com
Essential Biology 4.1 Chromosomes, Genes, Alleles, Mutations
Due Date:
Student Name:
Candidate Number: 002171-
In-class activity: Using gene databases
(ICT Databases)
1. Using the NCBI gene database at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene ,
identify the gene locus of the HBB (hemoglobin) gene.

2. Using the same database, look for the gene related to the illness PKU (phenylketonuria)
a. What is the gene name?

b. What is the gene locus of this gene?

c. Which enzyme is encoded by this gene?

d. What is the consequence of a base-substitution (mis-sense) mutation of this gene?

e. How is PKU diagnosed and why must it be diagnosed as early as possible?

3. Stem cells link:
Read this article: http://notexactlyrocketscience.wordpress.com/2007/12/08/sickle-cell-micecured-by-stem-cells-reprogrammed-from-their-own-tails/
a. What is an IPS stem cell?
b. Outline the use of this technology in treating the mice with sickle cell disease.
Stephen Taylor
Bandung International School
http://sciencevideos.wordpress.com
Essential Biology 4.1 Chromosomes, Genes, Alleles, Mutations
Due Date:
Student Name:
Candidate Number: 002171-
Works Cited
1. Allott, Andrew. IB Study Guide: Biology for the IB Diploma. s.l. : Oxford University Press, 2007. 978-019-915143-1.
2. Mindorff, D and Allott, A. Biology Course Companion. Oxford : Oxford University Press, 2007. 978099151240.
3. Clegg, CJ. Biology for the IB Diploma. London : Hodder Murray, 2007. 978-0340926529.
4. Campbell N., Reece J., Taylor M., Simon. E. Biology Concepts and Connections. San Fransisco :
Pearson Benjamin Cummings, 2006. 0-8053-7160-5.
5. Taylor, Stephen. Science Video Resources. [Online] Wordpress, 2010.
http://sciencevideos.wordpress.com.
6. Burrell, John. Click4Biology. [Online] 2010. http://click4biology.info/.
7. IBO. Biology Subject Guide. [Online] 2007. http://xmltwo.ibo.org/publications/migrated/productionapp2.ibo.org/publication/7/part/2/chapter/1.html.
Self Assessment:
Essential Biology
Criterion
Presentation &
Organisation
Academic
Honesty
Objective 1
understanding
Objective 2
understanding
Objective3
understanding
Logic, notation,
mathematical
working
Further research
Assessment
Complete (2)
Partially complete (1)
NA
Complete and neat. All command terms
highlighted, tables and diagrams well presented.
Self
Sources cited using the CSE (ISO 690 numerical)
method, with Works Cited section complete and
correct.
All answers for the following command terms
Most answers for the following command terms
correct:
correct:
Define
Draw
Label
List
Measure State
Most answers for the following command terms
All answers for the following command terms correct:
correct:
Annotate Apply
Calculate Describe Distinguish Estimate Identify
Outline
Most answers for the following command terms
All answers for the following command terms correct:
correct:
Analyse Comment Compare Construct Deduce Derive Design Determine Discuss
Evaluate
Explain Predict
Show Solve
Sketch Suggest
Answers are presented in a logical and concise
manner. SI units used most times, with correct
NA
unit symbols and definitions of terms. All
mathematical working shown.
Evidence is apparent of research and reading
beyond the textbook and presentations to find
correct answers to challenging questions. If any
NA
questions are unanswered, this criterion scores
zero.
NA
Total (max 10):
Stephen Taylor
Bandung International School
http://sciencevideos.wordpress.com
MrT