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北京大学生命科学学院
2013 学年春季学期系列学术讲座之十
题 目 ： The molecular mechanism of BRCA1 in DNA
damage response and tumor suppression
报告人：Xiaochun Yu
Associate professor, Department of Internal Medicine,
University of Michigan Medical School, Ann Arbor, MI
时间：2013 年 5 月 24 日（周五），下午 13:00-14:30 PM
地点：生命科学学院一楼邓祐才报告厅
Abstract:
Normal cells encounter numerous environmental and internal hazards during proliferation.
Proper DNA damage response helps cells protect genome integrity. Deregulation of this
cellular process results in chromosome instability, and eventually causes cancer. Many tumor
suppressors participate in DNA damage response. One typical example is BRCA1 (Breast
Cancer Susceptibility Gene 1). Mutation carriers of BRCA1 are predisposed to breast and
ovarian cancers, indicating that BRCA1 is a key tumor suppressor. Accumulated evidence
suggests that BRCA1 is involved in DNA damage-induced checkpoint activation and DNA
damage repair. However, the molecular mechanism by which BRCA1 participates in DNA
damage response remains elusive. Here, I will discuss of our recently findings on the role of
protein phosphorylation, ubiquitination and PARylation in BRCA1-dependent DNA damage
response. In particular, my talk will focus on protein PARylation, a unique posttranslational
modification that has been identified for more than 40 years. However, the role of PARylation
in response to DNA damage is not clear. Moreover, the inhibitors of protein PARylation can
specifically kill tumor cells bearing BRCA1 mutations. Again, the molecular mechanism
underlining this interesting phenomenon is not clear. I will present our recent data on the
functional interaction between PARylation and BRCA1 during DNA damage response. Our
results may explain not only a molecular mechanism of BRCA1 in DNA damage response but
also the mechanism by which PARP inhibitors kill breast tumor cells.
联系人：郑晓峰（电话：62755712）
欢迎各位老师和同学积极参加！