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Department of Tropical Medicine Seminar Series Contact Us Monday, April 25th 2:00-3:00 in JBJ 504 All seminars will be streamed live in TW 2302 for your convenience " Exploring the Unique Dual Function and the Evolutionary Relationship of the giardial epsin-like Protein" Dr. Maria Carolina Touz, PhD For more information on the DTM Seminar Series please contact Dr. Patricia Scaraffia, [email protected] or Dr. Juan Pizarro,[email protected] "Like" the Department of Tropical Medicine on Facebook! 1440 Canal Street Suite 2308 New Orleans, LA 70112 504.988.3561 Instituto Mercedes y Martín Ferreyra, Argentina Endocytosis and lysosomal protein trafficking is essential in pathogenic parasites since it is directly linked to vital parasite-specific processes, e.g. host cell invasion, nutrition, and cell differentiation into resistant stages, as in the case of Giardia. Recently, we have identified a protein containing an ENTH domain that defines monomeric adaptor proteins in the epsin family in Giardia. This domain is present in the epsin or epsin-related adaptor proteins, which are implicated in endocytosis and Golgito-endosome protein trafficking, respectively, in other eukaryotic cells. We found that G1ENTHp participates in the machinery for clathrin-mediated membrane budding acting as a dual epsin-epsinR protein. By using the yeast system to explore the similarities as well as the particularities of G1ENTHp as a member of the epsin family, we found that it acts as a nonfunctional epsinR in yeast cells, reinforcing the idea the G1ENTHp belongs to the epsinR subfamily present in eukaryotes prior to its evolution in different taxa. Dr. Touz obtained her PhD in Biochemistry from the National University of Cordoba. Her research interests include molecular mechanisms in Giardia lamblia.