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Transcript
Bone Sarcoma Biology: 20 years Later
Biology
Treatment
(Prognostication)
Sarcomas with
specific reciprocal
translocations
Sarcomas with
complex unbalanced
karyotypes
Biological Insights/Prognostic Factors
• Important to identify and describe, even
more critical will be to validate.
• Three interesting candidates in
osteosarcoma presented.
• Identified using very different modalities –
integrative analysis, deep sequencing,
proteomics.
Nalan Gokgoz
53 gene signature for outcome
Tadashi Kondo
Peroxiredoxin2 correlates with
response to induction
Leonardo A. Meza-Zepeda
RNA and DNA sequencing identified a translocation between
chromosome 17 and 6, involving the PMP22 and ELOVL5 genes
respectively.
Therapeutic Approaches
Francois Lamoureux
Ymera Pignochino
Inhibition of clusterin with
OGX-011 is synergistic with
zoledronate in osteosarcoma
Trabectidin and PARP-1
inhibition is synergisic
Randomized phase 2 trial in
chondrosarcoma – Andrew Wagner
• Hedgehog pathway - strong preclinical rationale
• Appropriate design and PFS endpoint – challenging
disease
• The planned biology studies may help understand the trial
results further