Download Date Revised: Fall 2006 COURSE SYLLABUS Syllabus for

Date Approved:
Date Revised: Fall 2006
(Text edition only; no content)
(Prerequisites only updated 7/07)
COURSE SYLLABUS
Syllabus for:
BIOL
2420
Genetics
Discipline
Number
Course Name
Former Course and Title:
Catalog
Description:
Credit Hours:
BIO 242 Genetics
This course is an introduction to the fundamental principles and
laws governing inheritance in plants and animals including man.
4
Prerequisite(s):
Contact Hours: 3 (lecture)
Lab Hours: 2
Documented eligibility for collegiate level English; BIOL 1110
(General Biology I)
Required
Text(s): (1) Genetics:
Approach
A Molecular
Russell
2nd / 2006
Benjamin Cummings
Title
Author(s)
Edition/Date
Publisher
Title
Author(s)
Edition/Date
Publisher
Title
Author(s)
Edition/Date
Publisher
(2)
(3)
Required Supplies/Material(s):
Recommended Supplementary Material(s):
Student Group for Whom Course is Required/Intended:
Science majors including
Biology majors
Motlow State Community College
Lynchburg, TN
Page 1 of 9
GOALS
GOALS: These should be broadly stated, measurable learner outcomes expected with the
completion of the course; use additional sheet(s) if necessary.
To demonstrate a knowledge of the history of genetics
To understand the structures and functions of DNA and RNA
To understand the functions of genes and gene products
To identify the classic Mendelian principles
To understand the mechanisms of non-Mendelian genetic
To compute statistical probabilities and outcomes
To differentiate between multiple allelic and polygenic traits
To demonstrate a knowledge of the various chromosomal abnormalities
To understand the mechanisms of mitosis and meiosis
To understand the role of chromosomal nondisjunction in genetic disorders
To interpret a genetic pedigree
To demonstrate a knowledge a various genetic syndromes and their causes
To use the Hardy-Weinberg equation to determine the statistical genome of a
population
To demonstrate a knowledge of various biotechnical procedures
To appreciate the role of genetic engineering and research in society
OBJECTIVES: These should be specifically stated, measurable learner outcomes to be met
throughout the course; use additional sheet(s) if necessary.
1.
Distinguish between prokaryotic and eukaryotic cells
2.
Define and recognize the structures and functions of cytoplasmic organelles
3.
Differentiate between sexual and asexual reproduction
4.
Define and recognize the stages of mitosis
5.
Define and recognize the stages of meiosis
6.
List the phases of the cell cycle
7.
Differentiate between plant and animal cytokinesis
8.
Define or recognize examples of the following: karyotype, genotype, phenotype,
homologous chromosomes, nonhomologous chromosomes, genes, alleles, gametes, selffertilization, cross-fertilization, monohybrid cross, dihybrid cross, test cross.
Motlow State Community College
Lynchburg, TN
Page 2 of 9
9.
List and explain Mendel's four laws
10.
Define the following terms: diploid, haploid, tetrad, somatic cell, germ cell,
fertilization, zygote, dominate, recessive, incomplete dominance.
11.
Use a Punnett square to illustrate a monohybrid and dihybrid cross and work out
the genotypic and phenotypic ratios expected from such crosses.
12.
Solve genetics problems.
13.
Read and translate a familial pedigree.
14.
Recognize the 1:2:1 and 2:1 ratios characteristic of incomplete dominance and
lethal alleles.
15.
State the possible genotypes of people with types A,B,AB and O and use knowledge
of multiple allelic traits to solve problems.
16.
Describe the different patterns of sex determination.
17.
Explain the role of chromosomal nondisjunction in genetic anomalies.
18.
Describe the possible events that can lead to chromosomal nondisjunction.
19.
Describe the role of the environment in determining traits.
20.
Describe and explain the following: genetic linkage, cross-over, genetic linkage,
cross-over, gene mapping.
21.
Demonstrate an ability to map genes onto chromosomes when provided with necessary
information.
22.
Define explain the following regarding bacterial and bacteriophage genetics:
transduction; transformation, conjugation; sex factor F; high frequency
recombination strains; mapping genes.
23.
Demonstrate a knowledge of the following regarding molecular genetics; gene
function; gen control of protein structure; structure of genetic material;
chemical composition of DNA and RNA,organization of DNA in chromosomes; DNA
replication and recombination; transcription and RNA processing; translation and
the structure of protein.
24.
Describe the structure of a molecule of DNA.
25.
List three differences between RNA and DNA.
26.
Differentiate between the structural variants of chromosomes: metacentric,
subcentric, acrocentric, telocentric
27.
Describe the genetic code and explain why it must be a triplet code.
28.
Given a DNA coding strand, determine the complimentary mRNA strand.
29.
Define DNA, mRNA, rRNA, tRNA, protein synthesis and mutation.
30.
Define and/or explain the following: restriction enzymes; cloning vectors;
construction of recombinant DNA libraries; using DNA probes; analysis of genes and
gene transcripts; polymerase chain reaction; DNA sequence analysis; DNA
Motlow State Community College
Lynchburg, TN
Page 3 of 9
fingerprinting: Human Genome Project; commercial products from biotechnology;
genetic engineering of plants.
31.
Demonstrate a knowledge of the following; levels of control of gene expression in
both prokaryotes and eukaryotes; gene regulation in development and
differentiation.
32.
Define and/or explain the following; mutation; types of mutations; causes of
mutations; classes of mutagens; DNA repair mechanisms; screening for the isolation
of mutations; transposable elements; tumor viruses; oncogenes and cancer.
33.
Demonstrate a knowledge of the following; organization of extranuclear genomes;
rules of extranuclear inheritance; examples of extranuclear inheritance; maternal
effect.
34.
Demonstrate an ability to apply the following concepts in quantitative genetic
through the working of problems or the analysis of data: samples and populations;
distributions; binomial theorem; mean, variance and standard deviation; polygenic
inheritance; heritability; response to selection.
35.
Display a working knowledge of the following regarding population genetics:
genotypic and allelic frequencies; Hardy-Weinberg Law; genetic variation in
natural populations, changes in allelic frequencies in populations; nonrandom
mating; evolutionary forces on the gene pool of a population: conservation
genetics; molecular evolution, including DNA polymorphisms.
LAB OBJECTIVES:
The learner will perform for assessment laboratory experiments and/or activities
involving the following:
mitosis
meiosis
chromosomal nondisjunction
transmission of genetic traits
monohybrid and dihybrid crosses
plant genetics
environmental influences on gene expression
fruit fly test crosses
DNA restriction analysis
gel electrophoresis
Hardy-Weinberg distribution problems
Motlow State Community College
Lynchburg, TN
Page 4 of 9
SUGGESTED EVALUATION PLAN
TASK
WEIGHT
Exam I:
Cell structure and reproduction
Mendelian genetics
Linkage and gene mapping
100 points
Exam II:
Genetic analysis
Gene function
Structure of genetic material
Organization of DNA in chromosomes
100 points
Exam III:
DNA replication and recombination
100 points
Genetic code
Cloning and recombination DNA technology
Exam IV:
Regulation of gene expression
100 points
Gene mutation
Chromosome mutation
Transposable elements, tumor viruses and oncogenes
FINAL:
Extranuclear genetics
Quantitative genetics
Population genetics
100 points
Lab reports: 50 points
Lab midterm 100 points
Lab final
100 points
FINAL GRADING PLAN
Based Upon Percentages
A =
90 - 100
B =
80 - 89
C =
70 - 79
D =
60 - 69
F =
59 or less
Additional Comments:
Motlow State Community College
Lynchburg, TN
Page 5 of 9
OBJECTIVES
INSTRUCTIONAL SCHEDULE
for
BIOL 2420
-
Genetics
Course Number and Name
Week
I.
II.
Objective
Numbers
1-14
15-19
Content to be Covered
I.
Cell structure
A. Prokaryote cell structure
B. Eukaryote cell structure
II.
Cellular reproduction in
eukaryotes
A. Chromosome complement
B. Asexual and sexual
reproduction
C. Mitosis: nuclear division
D. Meiosis
III.
Mendelian Genetics
A. Genotype and phenotype
B. Mendelian Principles
C. Monohybrid and Dihybrid
crosses
D. Pedigree analysis
I.
Chromosomal Basis of
Inheritance
A. Sex chromosomes
B. Sex linkage
C. Nondisjunction of X
Chromosomes
II.
Sex determination and linkage
in eukaryotes
A. Genotypic sex determination
systems
B. Phenotypic sex
determination systems
C. Analysis of sex-linked
traits in humans
III.
Extensions of Mendelian genetic
analysis
A. Multiple alleles
B. Incomplete dominance and
codominance
C. Gene interactions and
modified ratios
D. Essential and lethal genes
E. Relationship between
genotype and phenotype
Student Assignments/
Supplementary Material(s)
1. Textbook and lab assignments
2. Microscopy and models:
mitosis, meiosis, cell
structures
3. Attend lecture and lab
1. Textbook and lab assignments
2. Attend lecture and lab
3. Utilize LRC source
Motlow State Community College
Lynchburg, TN
Page 6 of 9
INSTRUCTIONAL SCHEDULE
for
BIOL 2420
-
Genetics
Course Number and Name
Week
Objective
Numbers
III.
20-21
Content to be Covered
I.
II.
III.
IV.
Student Assignments/
Supplementary Material(s)
Genetic Linkage
Gene mapping techniques
Mapping human genes
Tetrad analysis
EXAM I
Review EXAM I
IV.
V.
22-23
23-25
I.
Genetic analysis of bacteria
and bacteriophages
A. Bacteria
1. Gene mapping
2. Transformation
3. Conjugation
4. Transduction
B. Bacteriophages
1. Gene mapping
2. Fine structure analysis
of genes
3. Defining genes by
complementation tests
I. Molecular genetics: gene function
A. Gene control of enzyme
synthesis
B. Human genetic enzyme
deficiencies
C. Gene control of protein
syntheses
1.
2.
3.
Textbook and lab
assignments
Attend lecture and lab
Utilize LRC source
1. Textbook and lab assignments
2. Attend lecture and lab
3. Utilize LRC source
II. Structure and organization of
genetic material
A. Discovery of DNA and RNA
B. Nature of DNA and RNA
C. Chemical composition of DNA
and RNA
VI.
23,26
I. Organization of DNA in
chromosomes
A. Prokaryotic chromosomes
B. Bacteriophage λ Chromosome
C. Eukaryotic chromosomes
1.
2.
3.
EXAM II
Review EXAM II
Motlow State Community College
Lynchburg, TN
Page 7 of 9
Textbook and lab
assignments
Attend lecture and lab
Videotape:
"DNA: The Geometry of
Life"
INSTRUCTIONAL SCHEDULE
for
BIOL 2420
-
Genetics
Course Number and Name
Week
Objective
Numbers
VII.
23,29
VIII.
27-29
Content to be Covered
I.
DNA replication and recombination
A. In prokaryotes
B. In eukaryotes
II.
Transcription
A. Transcription process
B. Transcription: protein
coding genes
C. Transcription of other
genes
D. RNA processing
I.
Genetic code
A. Protein structure
B. Nature of the code
C. Translation of the genetic
message
D. Protein sorting in the cell
IX.
30
I. Cloning, Recombinant DNA
technology
A. Gene cloning
B. Construction of libraries
C. Identifying specific clones in
libraries
D. Analysis of genes and gene
transcript
E. Polymerase chain reaction
F. Application of recombinant
DNA technology
X.
31
I.
II.
III.
IV.
XI.
32
I.
II.
Student Assignments/
Supplementary Material(s)
1.
2.
Cloning, Recombinant DNA
technology
A. Lactose operon in E. coli
B. Tryptophan operon in E.
coli
Gene regulation in
bacteriophages
Gen expression in eukaryotes
Gene regulation in development
and differentiation
Gene mutation
Chromosome mutation
Motlow State Community College
Lynchburg, TN
Page 8 of 9
Textbook and lab
assignments
Attend lecture and lab
INSTRUCTIONAL SCHEDULE
for
BIOL 2420
-
Genetics
Course Number and Name
Week
Objective
Numbers
XII.
32,33
Content to be Covered
I.
Student Assignments/
Supplementary Material(s)
Transposable elements, tumor
viruses and oncogenes
EXAM IV
Review of EXAM IV
XIII.
33
I. Extranuclear genetic
A. Organization of extranuclear
genomes
B. Rules of extranuclear
inheritance
C. Examples of extranuclear
inheritance
D. Maternal effect
XIV.
34
I. Quantitative genetics
A. Continuous traits
B. Statistics
C. Polygenic inheritance
D. Heritability
E. Response to selection
XV.
35
I.
XVI.
33-35
FINAL EXAM
1.
2.
Population genetics
A. Gene frequencies
B. Hardy-Weinberg Law
C. Genetic variation in
natural populations
D. Changes in allelic
frequencies in populations
E. Nonrandom mating
II. Conservation genetics
III. Molecular evolution
Motlow State Community College
Lynchburg, TN
Page 9 of 9
Textbook and lab
assignments
Attend lecture and lab