* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download Schizophrenia as a model of disturbances in Non
Executive dysfunction wikipedia , lookup
Biology of depression wikipedia , lookup
Self-awareness wikipedia , lookup
Neuroeconomics wikipedia , lookup
Dual consciousness wikipedia , lookup
Emotional lateralization wikipedia , lookup
Neuroanatomy wikipedia , lookup
Cognitive neuroscience of music wikipedia , lookup
Temporoparietal junction wikipedia , lookup
Premovement neuronal activity wikipedia , lookup
Evolution of human intelligence wikipedia , lookup
Nervous system network models wikipedia , lookup
Synaptic gating wikipedia , lookup
Neurogenomics wikipedia , lookup
Mirror neuron wikipedia , lookup
Metastability in the brain wikipedia , lookup
Aging brain wikipedia , lookup
Neuropsychopharmacology wikipedia , lookup
Controversy surrounding psychiatry wikipedia , lookup
Clinical neurochemistry wikipedia , lookup
Embodied language processing wikipedia , lookup
Hum Tech! HumTec Seminar: Schizophrenia as a model of disturbances in Non-verbal Communication Yutaka Kato Department of Neuropsychiatry, Keio University School of Medicine Date: Monday 15, July, 2013 Description: Human mirror neuron system (MNS) consists of visuomotor neurons that fire both while the subject observes the goal-directed actions performed by others and while he himself performs similar actions. This system has raised the prospects of a "motor theory of social cognition" whose goal is to understand other’s actions and intentions directly often provided by its gestures as is used to non-verbal communication. Therefore the possible dysfunction of this mechanism could give rise to a certain types of neurophysiological conditions such as the disorders with social miscommunications. We have developed a novel paradigm to investigate the human MNS using magnetoencephalography, and made a comparison fifteen normal controls with fifteen medication-free schizophrenia patients. In normal controls, six brain regions, bilateral MT/ V5, inferior parietal (IPC) and premotor (PMC) cortices were sequentially activated while, the patients with schizophrenia elicited fewer activities in both hemispheres, which were more dominant in later responses from those corresponding to IPC regions. Dysfunction of the oscillation changes both in alpha and gamma band, which might be derived from the weaker phase-locking factors and gamma-synchronization predominantly in right inferior parietal cortex, emerged as the physiological correlates of the confusion of the sense of agency leading to the pathological experiences. The symptoms of schizophrenia can be formulated as a failure to recognize the self in action, e.g. misattributions of agency and delusions of control.