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Supporting information. Rat urinary glycoprotein identified from lectin captured protein lectin C J W Ref Protein name glycosylation coverage function Displays several functions associated with host defense: it promotes agglutination, o o o IPI00188225 C-reactive protein g 26.52 bacterial capsular swelling, phagocytosis and complement fixation through its calciumdependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells o o o IPI00188967 Ig kappa chain C region ns 55.66 o o o IPI00190943 Glial fibrillary acidic protein, astrocyte s 2.56 o o o IPI00191711 Major urinary protein p 82.32 o o o IPI00191715 Alpha-1-acid glycoprotein po 27.80 o o o IPI00191737 GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells Binds pheromones that are released from drying urine of males. These pheromones affect the sexual behavior of females Appears to function in modulating the activity of the immune system during the acutephase reaction Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Serum albumin ns 67.11 Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood Part of prostatein which is the major secretory glycoprotein of ventral prostate gland. o o o IPI00191771 Prostatic steroid-binding protein C3 chain g 13.68 Steroid-binding protein; can bind non-polar steroids, cholesterol and a group of small proline-rich peptides o o o IPI00191773 Prostatic steroid-binding protein C2 chain p 35.71 Part of prostatein which is the major secretory glycoprotein of ventral prostate gland o o o IPI00191774 Prostatic steroid-binding protein C1 chain s 37.84 Part of prostatein which is the major secretory glycoprotein of ventral prostate gland o o o IPI00193171 Epididymal secretory protein 1 ns 26.85 o o o IPI00195063 13 kDa protein ns 10.83 o o o IPI00195148 Liver carboxylesterase 1 po 14.75 o o o IPI00195160 Sulfated glycoprotein 1 po 6.32 o o o IPI00195516 Hemopexin po 29.78 o o o IPI00195685 CD44 protein s 3.08 o o o IPI00196249 Limitrin po 13.8 o o o IPI00196656 Ba1-667 ns 38.88 o o o IPI00198021 Uromodulin po 30.75 o o o IPI00198466 Amy1 protein s 51.82 o o o IPI00199448 Mama s 9.93 o o o IPI00199695 s 10.59 Belongs to the serpin family o o o IPI00200422 Alpha2u globulin s 12.15 Belongs to the lipocalin family o o o IPI00200591 Contrapsin-like protease inhibitor 3 po 40.92 By growth hormone. Reduced during acute inflammation o o o IPI00200593 Contrapsin-like protease inhibitor 1 po 40.87 Binds to and inhibits kallikreins. Inhibits trypsin but not chymotrypsin or elastase Serine (Or cysteine) peptidase inhibitor, clade F, member 2 Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation May play a role in the maturation and maintenance of blood-brain barrier May play a role in regulating the circulating activity of cytokines as it binds to IL-1, IL-2 and TNF with high affinity Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, o o o IPI00200757 Fibronectin po 2.22 DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Interaction with TNR mediates inhibition of cell adhesion and neurite outgrowth Protease inhibitor with a wide spectrum of protein targets, which attaches through its o o o IPI00201262 Alpha-1-inhibitor 3 po 33.51 o o o IPI00201592 Glandular kallikrein-7, submandibular/renal po 25.29 o o o IPI00201596 Alpha-2u globulin s 4.97 Belongs to the lipocalin family o o o IPI00201616.1 ALPHA-2U GLOBULIN. s 18.23 Belongs to the lipocalin family o o o IPI00201617.1 ALPHA-2U GLOBULIN. s 24.86 Belongs to the lipocalin family thioester function Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lysbradykinin. Predominant kallikrein protein in the kidney Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic o o o IPI00203102 Prostaglandin-H2 D-isomerase g 8.99 molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 o o o IPI00203149 Interleukin-4 receptor alpha chain po 1.62 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammmation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 o o o IPI00204359 Beta-2-microglobulin ns 19.33 o o o IPI00204777 Common salivary protein 1 s 55.97 o o o IPI00205208 Cystatin-related protein 1 g 46.59 Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules o o o IPI00205210 Cystatin-related protein 2 p 27.27 This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The o o o IPI00205255 Polymeric-immunoglobulin receptor p 11.44 complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separate the extracellular (known as the secretory component) from the transmembrane segment o o o IPI00205273 Urinary protein 1 po 32.67 o o o IPI00205275 Urinary protein 2 po 32.67 o o o IPI00205325 po 14.94 o o o IPI00205971 Urinary protein 3 s 35.64 Low-density lipoprotein receptor-related protein 2 Acts together with cubilin to mediate HDL endocytosis. Receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracelular GSH level. It is part of the cell antioxidant o o o IPI00206254 Gamma-glutamyltranspeptidase 1 po 4.58 defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate o o o IPI00206623 Beta-glucuronidase po 14.04 Plays an important role in the degradation of dermatan and keratan sulfates Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to o o o IPI00206662 Epithelial-cadherin po 12.53 the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cellcell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation; in ovulation it weakens the walls of the Graafian follicle. It activates the o o o IPI00206780 Plasminogen ns 12.44 urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. It cleaves fibrin, fibronectin, thrombospondin, laminin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo o o o IPI00206823.1 ALPHA-2U GLOBULIN. s 44.20 o o o IPI00206980 Apomucin s 6.21 o o o IPI00207668 Afamin po 33.88 o o o IPI00208410 Probasin ns 16.38 Belongs to the lipocalin family Possible role in the transport of yet unknown ligand Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha- o o o IPI00209265 Gamma-glutamyl hydrolase po 22.71 glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates. Exhibits either endo- or exopeptidase activity depending upon the tissue of origin. When secreted, it acts primarily as an endopeptidase Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys- o o o IPI00209517 Submandibular glandular kallikrein-9 p 20.46 bradykinin. This enzyme has a vasoconstrictor activity. KLK-9 has both a chymotrypsin-like and a trypsin-like properties In response to lowered blood pressure, the enzyme renin cleaves angiotensin-1, from o o o IPI00209744 Angiotensinogen po 6.92 angiotensinogen. ACE (angiotensin converting enzyme) then removes a dipeptide to yield the physiologically active peptide angiotensin-2, the most potent pressor substance known, which helps regulate volume and mineral balance of body fluids o o o IPI00210091 Serine protease inhibitor A3M po 11.69 The single human alpha1-antichymotrypsin gene (SERPINA3) is represented by a cluster of 6 individual rat paralogs o o o IPI00210524 40 kDa protein s 15.36 o o o IPI00210824 Corticosteroid-binding globulin po 10.86 o o o IPI00210872 Meprin A subunit alpha po 21.26 Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species Hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues Alpha-1-microglobulin occurs in many physiological fluids including plasma, urine, and cerebrospinal fluid. It appears not only as a free monomer but also in complexes with IgA and albumin. Inter-alpha-trypsin inhibitor, present in plasma and urine, inhibits trypsin, o o o IPI00210900 AMBP protein po 15.76 plasmin, and lysosomal granulocytic elastase. Trypstatin is a trypsin inhibitor. It inhibits blood coagulation factor Xa and tryptase about 100-fold more rapidly than porcine pancreatic trypsin and chymase. It is a monomer but is also found in mast cells as a complex with tryptase Factor D cleaves factor B when the latter is complexed with factor C3b, activating the o o o IPI00212480 Complement factor D g 10.27 C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway o o o IPI00212697 Napsin s 16.19 o o o IPI00212708 Fetuin-B po 30.03 o o o IPI00212731 Cathepsin D po 7.37 Acid protease active in intracellular protein breakdown o o o IPI00212767 Anionic trypsin-1 s 8.13 Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa o o o IPI00212811 Cathepsin B g 25.07 Belongs to the fetuin family Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis C4 plays a central role in the activation of the classical pathway of the complement system. It is processed by activated C1 which removes from the alpha chain the C4a o o o IPI00213036 Complement C4 g 7.25 anaphylatoxin. Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory processes. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes o o o IPI00213541 12 kDa protein ns 11.30 o o o IPI00213958 Prostatic spermine-binding protein g 15.05 o o o IPI00215300 C-CAM4 s 18.31 Spermine-binding protein is an androgen regulated ventral prostate glycoprotein that binds various polyamines Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May be involved in the o o o IPI00230862 Aminopeptidase N po 18.46 metabolism of regulatory peptides of diverse cell types. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells. May have a role in angiogenesis o o o IPI00230876 Deoxyribonuclease-1 po 47.54 o o o IPI00231643 Superoxide dismutase s 35.95 Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization Destroys radicals which are normally produced within the cells and which are toxic to biological systems As an inhibitor of cysteine proteinases, this protein is thought to serve an important o o o IPI00231801 Cystatin C s 42.14 physiological role as a local regulator of this enzyme activity. Known to inhibits cathepsin B, H, and L o o o IPI00231848 Pro-epidermal growth factor po 19.51 o o o IPI00324019 Alpha-1-antiproteinase po 49.39 EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture Inhibitor of serine proteases. The primary target is elastase, but also has a moderate affinity for plasmin and thrombin o o o IPI00324380 Transthyretin po 30.61 Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has o o o IPI00325847 Ceruloplasmin po 3.6 ferroxidase activity oxidizing iron(II) to iron(III) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. May also play a role in fetal lung development or pulmonary antioxidant defense Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational o o o IPI00326140 Alpha-1-macroglobulin po 28.33 change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates. Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase Isoform 1 is detectable at all developmental stages starting from postnatal day 1. Isoform 2 o o o IPI00326260 Neuroplastin po 8.4 is low at postnatal day 1, increases steadily until postnatal days 20-25 and then declines to an intermediate level Kininogens are plasma glycoproteins with a number of functions: (1) as precursor of the active peptide bradykinin they effect smooth muscle contraction, induction of hypotension o o o IPI00327182 T-kininogen 1 po 26.62 and increase of vascular permeability. (2) They play a role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII. (3) They are inhibitor of thiol proteases Could inhibit both insulin-receptor tyrosine kinase activity and insulin-stimulated receptor o o o IPI00327469 Alpha-2-HS-glycoprotein po 18.18 autophosphorylation and, concomitantly, antagonize the mitogenic effect of the hormone in cultured rat hepatoma cells o o o IPI00358444 cDNA sequence BC048546 s 17.60 o o o IPI00360737 similar to alpha 3 type VI collagen isoform 2 s 3.34 o o o IPI00361346 LOC367586 protein s 21.48 o o o IPI00365221 po 19.07 o o o IPI00366081 desmoplakin isoform I isoform s 5.32 o o o s 26.50 o o o IPI00368219 Gastric triacylglycerol lipase s 20.03 o o o IPI00371132 Bet-galactosidase s 14.68 o o o IPI00372372 s 30.54 o o o IPI00388265 48 kDa protein s 45.62 o o o IPI00390975 57 kDa protein s 12.5 o o o s 7.18 IPI00367761.4 EGF-containing fibulin-like extracellular matrix protein 1 SIMILAR TO PROSTATIC SPERMINEBINDING PROTEIN PRECURSOR. Serine (Or cysteine) peptidase inhibitor, clade C (Antithrombin), member 1 IPI00392753.2 ALPHA-2U GLOBULIN. Protease inhibitor with a wide spectrum of protein targets, which attaches through its thioester function Belongs to the lipocalin family Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of o o o IPI00421429 Junction plakoglobin s 14.9 both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques o o o IPI00464785 Protective protein for beta-galactosidase s 10.53 Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in o o o IPI00475946 Serotransferrin po 5.85 association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation C3 plays a central role in the activation of the complement system. Its processing by C3 o o o IPI00480639 Complement C3 p 8.72 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates o o o o o o o o o o o o IPI00559211 11 kDa protein s 22.92 s 17.22 IPI00763182 Urinary protein 3 precursor ns 50 o IPI00763610 lipocalin 13 s 15.47 o o IPI00767210 Prostatic steroid-binding protein C1 ns 35.04 o o o s 11.36 o o IPI00195173 CD59 glycoprotein po 7.14 o o IPI00196145 Interferon gamma inducible protein 30 s 5.65 o o IPI00200614 Regenerating islet-derived protein 3 gamma s 21.26 o o IPI00202887 Decay-accelarating factor s 2.96 o o IPI00206658 Pre-eosinophil-associated ribonuclease-2 s 12.26 o o IPI00207475 Endothelial cell-selective adhesion molecule po 12.18 o o IPI00213615 po 5.22 o o IPI00325146 Annexin A2 s 4.13 IPI00563352.3 ALPHA-2U GLOBULIN. IPI00769183.2 SIMILAR TO ROBO-1. N(4)-(Beta-N-acetylglucosaminyl)-Lasparaginase Belongs to the lipocalin family Potent inhibitor of the complement membrane attack complex (MAC) action. Acts at or after the C5b-8 stage of MAC assembly Might be a stress protein involved in the control of bacterial proliferation Can mediate aggregation most likely through a homophilic molecular interaction Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparaginelinked glycoproteins Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity o o IPI00358343 14 kDa protein ns 23.85 o o IPI00371899 15 kDa protein s 8.7 o o s 18.32 o o s 10.04 o o s 8.84 o o IPI00568085 19 kDa protein s 15.06 o o IPI00655254 LRRGT00161 s 5.15 o o ns 12.80 Po, O 1.86 s 9.17 IPI00389939.3 15 KDA PROTEIN. IPI00421761 Glandular kallikrein-11 IPI00554102.3 SIMILAR TO ALPHA2U GLOBULIN. IPI00780603.1 14 KDA PROTEIN. o o IPI00188909 Collagen alpha-1(I) chain o o IPI00194927 RoBo-1 Belongs to the lipocalin family Type I collagen is a member of group I collagen (fibrillar forming collagen) Binds to various kinds of negatively charged substances such as heparin, phospholipids, o o IPI00195241 Beta-2-glycoprotein 1 po 7.41 and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands required calcium. Serves as important transporter in several absorptive o o IPI00196620 Cubilin po 4.58 epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface o o IPI00198494 Prolactin-inducible protein homolog po 23.97 Belongs to the PIP family Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta- o o IPI00203152 Di-N-acetylchitobiase po 7.36 D-glucosamine (1-5)N-acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase o o IPI00208422 Dipeptidyl peptidase 4 po 9.00 o o IPI00210968 Odorant-binding protein s 7.95 o o IPI00230946 Dipeptidyl-peptidase 2 po 21.8 Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted Ntermini provided that the penultimate residue is proline Plays an important role in the degradation of some oligopeptides (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) o o IPI00231282 Kininogen-1 po 2.31 induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMWkininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting o o IPI00327398 Glutamyl aminopeptidase po 6.03 o o IPI00365241 L-amino acid oxidase 1 s 11.47 o o IPI00368115 46 kDa protein s 3 o o IPI00391338 ICOS ligand s 2.75 Appears to have a role in the catabolic pathway of the renin-angiotensin system. Isoform 1 has aminopeptidase activity while isoform 2 does not Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational o o IPI00392886 Alpha-2-macroglobulin po 0.88 change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase o o IPI00400579 Lysosomal alpha-glucosidase o o IPI00475984 53 kDa protein po 1.05 s 5.26 Essential for the degradation of glygogen to glucose in lysosomes Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are o IPI00188524 Neurofilament heavy polypeptide s 3.10 involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins o IPI00188800 103 kDa protein s 1.96 o IPI00189036 ABC transporter, white homologue s 1.28 o IPI00191437 64 kDa protein s 5.05 Involved in the initial immune cell clustering during inflammatory response and may o IPI00194733 Attractin po 2.57 regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti. Has a critical role in normal myelination in the central nervous system o IPI00199497 Leukemia inhibitory factor receptor po 1.19 o IPI00200344 Retinoid-inducible serine carboxypeptidase po 3.98 o IPI00201347 Histidine-rich glycoprotein 2 s 1.24 Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells May be involved in vascular wall and kidney homeostasis Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system. It is not able to receive electrons from o IPI00201561 Peroxiredoxin-2 s 0.86 glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) o IPI00203203 Fragile-X mental retardation related protein 2 s 1.93 G protein-coupled receptor that probably associates with the patched protein (PTCH) to o IPI00206713 Smoothened homolog po 1.89 transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). o IPI00208027 Trefoil factor 3 s 19.75 o IPI00208659 Platelet complement factor H s 5.83 May have a role in promoting cell migration (motogen) o IPI00210193 Titin s 0.05 Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important o IPI00211779 Peroxiredoxin-1 s 5.03 role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) o IPI00211883 Cadherin-11 s 1.26 Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1/Tip60 and inhibit Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity. Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. May be involved in copper homeostasis/oxidative stress through copper ion reduction. Can regulate neurite outgrowth through binding to components of the extracellular matrix such o IPI00212319 Amyloid beta A4 protein Po, O 1.69 as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Beta-amyloid peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. Rat and mouse beta-amyloid peptides bind only weakly transient metals and have little reducing activity due to substitutions of transient metal chelating residues. Beta-APP42 may activate mononuclear phagocytes in the brain and elicit inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation. Appicans elicit adhesion of neural cells to the extracellular matrix and may regulate neurite outgrowth in the brain. The gammaCTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis A proteinase activates the inhibitor by specific proteolysis in the bait region, which, by an unknown mechanism leads to reaction at the cysteinyl-glutamyl internal thiol ester site and to a conformational change, whereby the proteinase is trapped and/or covalently bound to o IPI00212666 Murinoglobulin-1 po 10.63 the inhibitor. While in the tetrameric proteinase inhibitors steric inhibition is sufficiently strong, monomeric forms need a covalent linkage between the activated glutamyl residue of the original thiol ester and a terminal amino group of a lysine or another nucleophilic group on the proteinase, for inhibition to be effective o IPI00212694 EGF receptor s 1.49 o IPI00213847 Granulins po 7.47 o IPI00231136 Nidogen-1 s 0.96 o IPI00231631 Beta-enolase s 4.16 o IPI00231929 Pyruvate kinase isozymes M1/M2 s 4.32 Belongs to the protein kinase superfamily. Tyr protein kinase family Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling Appears to have a function in striated muscle development and regeneration Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial o IPI00231949 Monocyte differentiation antigen CD14 po 2.96 lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules o IPI00358704 Desmocollin 2 s 1.44 o IPI00362538 ubiquitin-conjugating enzyme E2Q s 2.03 o IPI00367093 Lachrymal protein s 22.83 o IPI00368397 Igha_mapped protein s 7.47 o IPI00369047 Odorant-binding protein s 6.36 Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules This protein is found in nasal epithelium and it binds a wide variety of chemical odorants o IPI00370706 Lactoperoxidase s 8.04 o IPI00372469 85 kDa protein s 2.1 Probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. Degrades catecholamines o IPI00372522 Renalase s 5.71 such as dopamine, norepinephrine and epinephrine in vitro (By similarity). Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk Haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the o IPI00382202 Ba1-647 po 6.82 kidneys and protecting the kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes o IPI00392907 keratinocytes proline-rich protein s 6.54 o IPI00393340 Hypothetical protein s 1.81 o IPI00411191 MHC class Ib antigen s 3.26 o IPI00421601 N-acylsphingosine amidohydrolase 1 s 3.05 o IPI00421857 Cytokeratin type I s 8 o IPI00421981 RT1 class I, CE15 s 3.22 Involved in the presentation of foreign antigens to the immune system o IPI00421984 RT1 class I, CE11 s 3.27 Involved in the presentation of foreign antigens to the immune system Involved in the presentation of foreign antigens to the immune system Functions as an E1 enzyme essential for multisubstrates such as GABARAPL1 and o IPI00471650 Autophagy-related protein 7 s 1.58 ATG12. Forms intermediate conjugates with GABARAPL1 (GABARAPL2, GABARAP or MAP1ALC3). Formation of the final GABARAPL1-PE conjugate is essential for autophagy o IPI00561733 29 kDa protein s 5.11 o IPI00562229 14 kDa protein ns 11.57 A proteinase activates the inhibitor by specific proteolysis in the bait region, which, by an unknown mechanism leads to reaction at the cysteinyl-glutamyl internal thiol ester site and to a conformational change, whereby the proteinase is trapped and/or covalently bound to o IPI00564327 Murinoglobulin 2 po 0.82 the inhibitor. While in the tetrameric proteinase inhibitors steric inhibition is sufficiently strong, monomeric forms need a covalent linkage between the activated glutamyl residue of the original thiol ester and a terminal amino group of a lysine or another nucleophilic group on the proteinase, for inhibition to be effective o IPI00567122 17 kDa protein s 14.12 o IPI00758468 Pgcp protein po 5.3 o IPI00777596 393 kDa protein s 0.03 o IPI00778430 37 kDa protein s 6.73 o IPI00778633 Apolipoprotein H s 4.93 o IPI00781465 29 kDa protein s 5.3 s 3.00 po 19.17 s 10.08 po 2.27 INTER-ALPHA-INHIBITOR H4 HEAVY o o IPI00188541.3 o o IPI00188731.1 CD48 ANTIGEN PRECURSOR. o o IPI00189813.1 ACTIN, ALPHA SKELETAL MUSCLE. o o IPI00189981.1 CHAIN. PROTHROMBIN PRECURSOR (FRAGMENT). Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C o o IPI00192302.2 99 KDA PROTEIN. s 2.48 Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on o o IPI00194097.5 VITAMIN D-BINDING PROTEIN PRECURSOR. the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents po 22.69 polymerization of actin by binding its monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes o o IPI00200640.1 o o o ISOFORM 1 OF MUCIN AND CADHERIN- po 4.06 IPI00202440.3 IGH-1A PROTEIN. s 17.48 o IPI00204993.1 SIMILAR TO SLIT-LIKE 2. s 4.16 o o IPI00209782.4 SIMILAR TO VOMEROMODULIN. s 13.10 o o IPI00210120.2 AA1018. s 9.59 o o IPI00211075.1 Serine protease inhibitor A3N precursor po 7.66 o o IPI00211648.1 LIKE PROTEIN PRECURSOR. NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT. Acts as a calcium-dependent cell adhesion protein The single human alpha1-antichymotrypsin gene (SERPINA3) is represented by a cluster of 6 individual rat paralogs Involved in the high-affinity sodium-independent transport of cystine and neutral and po 6.44 dibasic amino acids (system B(0,+)-like activity). May function as an activator of SLC7A9 and be involved in the high-affinity reabsorption of cystine in the kidney proximal tubule A proteinase activates the inhibitor by specific proteolysis in the bait region, which, by an unknown mechanism leads to reaction at the cysteinyl-glutamyl internal thiol ester site and o o IPI00212666.1 ISOFORM 1 OF MURINOGLOBULIN-1 PRECURSOR. to a conformational change, whereby the proteinase is trapped and/or covalently bound to po 9.28 the inhibitor. While in the tetrameric proteinase inhibitors steric inhibition is sufficiently strong, monomeric forms need a covalent linkage between the activated glutamyl residue of the original thiol ester and a terminal amino group of a lysine or another nucleophilic group on the proteinase, for inhibition to be effective o o IPI00212753.4 13 KDA PROTEIN. ns 23.28 Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective o o IPI00231193.3 NERVE GROWTH FACTOR, GAMMA. p 8.68 action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa o o IPI00231767.4 TRIOSEPHOSPHATE ISOMERASE. o o IPI00231848.10 PRO-EPIDERMAL GROWTH FACTOR PRECURSOR. s 5.24 po 13.86 D-glyceraldehyde 3-phosphate = glycerone phosphate EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture May play a role in cell cycle regulation during anaphase and/or telophase, in relation to the o o IPI00325622.5 Serine/threonine-protein kinase 6 s 15.27 function of the centrosome/spindle pole region during chromosome segregation. Maybe involved in microtubule formation and/or stabilization. May play a key role during tumor development and progression Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has o o IPI00325847.3 GPI-ANCHORED CERULOPLASMIN. po 13.56 ferroxidase activity oxidizing iron(II) to iron(III) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. May also play a role in fetal lung development or pulmonary antioxidant defense SERUM AMYLOID P-COMPONENT o o IPI00327745.1 o o IPI00359024.2 o o IPI00361342.3 SIMILAR TO CLM3. PRECURSOR. EXTRA CELLULAR LINK DOMAINCONTAINING 1. p 30.26 s 12.83 s 2.27 SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin o o IPI00363974.3 GELSOLIN. s 12.42 monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed o o IPI00364039.3 RGD1311906 PROTEIN (FRAGMENT). s 1.93 o o IPI00368397.2 BWK3. s 9.34 o o IPI00369140.3 38 KDA PROTEIN. s 15.43 o o IPI00370486.3 IG LAMBDA-2 CHAIN C REGION. s 57.14 o o IPI00371830.3 SIMILAR TO PROTEASE INHIBITOR 16. s 4.97 Beta-3-microglobulin is the beta-chain of major histocompatibility complex class I molecules Contains 1 Ig-like (immunoglobulin-like) domain Probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. Degrades catecholamines o o IPI00372792.1 PLASMA PROTEASE C1 INHIBITOR PRECURSOR. po 18.85 such as dopamine, norepinephrine and epinephrine in vitro (By similarity). Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk o o o o IPI00382185.2 DA1-24. IPI00382202.1 ISOFORM 2 OF HAPTOGLOBIN PRECURSOR. s 2.68 Haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the po 7.09 kidneys and protecting the kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes o o IPI00388002.2 LOC500180 PROTEIN. s 13.68 o o IPI00390968.3 14 KDA PROTEIN. ns 27.48 o o IPI00392208.3 15 KDA PROTEIN. s 9.63 o o IPI00392266.3 11 KDA PROTEIN. ns 32.00 o o IPI00393340.2 LOC683313 PROTEIN. s 3.99 o o IPI00393521.2 o o o LEUCINE-RICH ALPHA-2- s 4.22 IPI00471669.1 GLYPICAN 4. s 7.18 o IPI00476292.3 121 KDA PROTEIN. s 1.23 o o IPI00555216.1 IGHA_MAPPED PROTEIN. s 5.13 o o IPI00556973.1 15 KDA PROTEIN. s 27.01 o o IPI00558944.3 12 KDA PROTEIN. ns 25.23 o o IPI00559142.1 PLEXIN DOMAIN CONTAINING 2 s 2.26 o o IPI00559877.2 12 KDA PROTEIN. s 16.67 o o IPI00563737.1 14 KDA PROTEIN. ns 19.20 o o IPI00563941.3 13 KDA PROTEIN. ns 16.24 o o IPI00567155.2 14 KDA PROTEIN. s 11.11 o o IPI00568528.1 85 KDA PROTEIN. s 1.87 o o IPI00763182.1 s 58.00 o o IPI00785608.1 ALPHA-2U GLOBULIN. s 13.26 o IPI00188142.1 ASPARTOACYLASE (AMINOACYLASE) 3. s 4.08 o IPI00188688.1 HISTONE H2A. s 21.54 GLYCOPROTEIN 1. SIMILAR TO URINARY PROTEIN 3 PRECURSOR. Belongs to the glypican family Belongs to the lipocalin family o IPI00188879.2 LAMIN C2. o IPI00189714.4 o IPI00190240.1 RIBOSOMAL PROTEIN S27A. o IPI00191738.1 o IPI00191767.5 TRIOSEPHOSPHATE ISOMERASE o IPI00193169.1 SIMILAR TO COLLAGEN ALPHA-1(XII) CHAIN PRECURSOR. GLUTAMATE--CYSTEINE LIGASE REGULATORY SUBUNIT ISOFORM 1 OF WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 2 PRECURSOR. s 2.60 s 1.66 s 10.26 s 5.59 s 15.79 s 7.74 This ribosomal protein is synthesized as a C- terminal extension protein (CEP) of ubiquitin ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine D-glyceraldehyde 3-phosphate = glycerone phosphate Contains 2 WAP domains Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T lymphocytes. o IPI00200683.1 SIMILAR TO PLASMA RETINOL-BINDING PROTEIN PRECURSOR. O 3.75 Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF- alpha and may also regulate protease secretion. Inhibits bone mineralization o IPI00204818.2 PROTEIN S100-A6. o IPI00205201.5 o IPI00211336.1 o IPI00230862.7 SIMILAR TO SIALATE OACETYLESTERASE PRECURSOR. SIMILAR TO SH3 DOMAIN BINDING GLUTAMIC ACID-RICH PROTEIN-LIKE 3. PRO-EPIDERMAL GROWTH FACTOR PRECURSOR. s 8.99 po 2.21 s po Catalyzes the removal of O-acetyl ester groups from position 9 of the parent sialic acid, Nacetylneuraminic acid 10.3 3.42 EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture o IPI00231118.4 CALBINDIN. s 5.00 Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase C9 is the final component of the complement system to be added in the assembly of the o IPI00231423.6 C9 PROTEIN. po 6.35 membrane attack complex. It is able to enter lipid bilayers, forming transmembrane channels Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in o IPI00231615.4 ANNEXIN A1. s 15.65 exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity o IPI00231848.10 TRANSTHYRETIN PRECURSOR. o IPI00324380.3 o IPI00324445.3 GASTRICSIN PRECURSOR. o IPI00339126.2 SIMILAR TO ALPHA 3 TYPE VI COLLAGEN ISOFORM 2 PRECURSOR. POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 1. o IPI00358286.4 13 KDA PROTEIN. o IPI00358707.3 o IPI00360196.4 SIMILAR TO CALMODULIN 4. ZINC FINGER, FYVE DOMAIN CONTAINING 9 po 3.88 po 43.54 s 3.06 EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain Hydrolyzes a variety of proteins Pore-forming (alpha) subunit of voltage-gated non- inactivating delayed rectifier potassium po 1.35 channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in myoblasts ns 13.33 s 2.24 s 15.65 s 1.70 s 5.69 SERINE (OR CYSTEINE) PEPTIDASE o IPI00372372.2 INHIBITOR, CLADE C (ANTITHROMBIN), MEMBER 1. o IPI00361798.2 INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 7. Contains 1 IGFBP N-terminal domain o IPI00363760.4 SORTING NEXIN 8. s 3.28 o IPI00365395.2 EPHRIN-B2 PRECURSOR. s 10.42 o IPI00366848.3 s 2.49 o IPI00372372.2 ALPHA-2U GLOBULIN. s 2.58 o IPI00387666.3 17 KDA PROTEIN. s 17.65 o IPI00389419.2 IGHA_MAPPED PROTEIN. s 2.30 o IPI00389806.4 LOC498793 PROTEIN. s 2.74 o IPI00391528.2 13 KDA PROTEIN. s 10.43 o IPI00400746.1 po 0.72 o IPI00421295.2 s 5.91 o IPI00421832.1 DERMCIDIN. s 22.73 o IPI00554226.1 s 4.38 o IPI00557120.2 12 KDA PROTEIN. ns 13.76 o IPI00557643.2 13 KDA PROTEIN. ns 11.21 o IPI00557941.3 15 KDA PROTEIN. s 10.87 SIMILAR TO NONSPECIFIC CYTOTOXIC CELL RECEPTOR PROTEIN 1. PROTEIN C1ORF9 HOMOLOG PRECURSOR ACIDIC MAMMALIAN CHITINASE PRECURSOR. COMPLEMENT COMPONENT FACTOR HLIKE 1. Belongs to the lipocalin family Single-pass type I membrane protein Degrades chitin and chitotriose. May participate in the defense against nematodes and other pathogens o IPI00559211.2 o SIMILAR TO URINARY PROTEIN 3 s 22.92 IPI00559410.1 14 KDA PROTEIN. s 10.53 o IPI00559639.2 12 KDA PROTEIN. ns 10.19 o IPI00560431.2 13 KDA PROTEIN. ns 15.13 o IPI00561466.1 12 KDA PROTEIN. s 9.17 o IPI00562105.2 12 KDA PROTEIN. ns 17.31 o IPI00562465.2 14 KDA PROTEIN. ns 12.90 o IPI00562653.1 CATHEPSIN B PREPROPROTEIN. s 3.24 o IPI00564011.2 12 KDA PROTEIN. ns 16.67 o IPI00564145.2 12 KDA PROTEIN. ns 15.60 s 66.00 PRECURSOR. SIMILAR TO PROSTATIC STEROID- o IPI00763182.1 BINDING PROTEIN C1 CHAIN PRECURSOR. o IPI00779863.1 24 KDA PROTEIN. s 12.56 o IPI00779864.1 42 KDA PROTEIN. s 12.56 IPI00189819.1 ACTIN, CYTOPLASMIC 1. s 4.80 o Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as o IPI00190701.5 APOLIPOPROTEIN E PRECURSOR. s 3.53 a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues o IPI00191789.1 HISTIDINE-RICH GLYCOPROTEIN. s 9.61 o IPI00198667.7 CLUSTERIN PRECURSOR. p 8.28 o IPI00200792.3 56 KDA PROTEIN. s 9.27 o IPI00201276.5 po 2.84 o IPI00201622.3 LYSOSOMAL ACID PHOSPHATASE PRECURSOR. GROWTH-ARREST-SPECIFIC PROTEIN 6 PRECURSOR. o IPI00204217.2 58 KDA PROTEIN. o IPI00204808.5 MEPRIN A SUBUNIT BETA PRECURSOR. o IPI00205568.1 KALLISTATIN. o IPI00205907.5 o po 1.78 po 2.13 s 12.77 po 5.56 IPI00207146.1 ZERO BETA-1 GLOBIN. s 8.16 o IPI00215382.4 IG KAPPA CHAIN V REGION S211. s 13.76 o IPI00327182.7 48 KDA PROTEIN s 3.13 o o IPI00327469.1 IPI00363899.5 ALPHA-2-HS-GLYCOPROTEIN PRECURSOR. SIMILAR TO ALPHA-FETOPROTEIN PRECURSOR. A phosphate monoester + H(2)O = an alcohol + phosphate implicated in cell growth and survival, cell adhesion and cell migration. Plays a role in thrombosis by amplifying platelet aggregation and secretion in response to known agonists 1.58 ASSOCIATED LIPOCALIN PRECURSOR. membranes and hydrophobic proteins. It has been associated with programmed cell death Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is s NEUTROPHIL GELATINASE- It is known to be expressed in a variety of tissues and it seems to be able to bind to cells, Hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues Could inhibit both insulin-receptor tyrosine kinase activity and insulin-stimulated receptor po 5.32 autophosphorylation and, concomitantly, antagonize the mitogenic effect of the hormone in cultured rat hepatoma cells po 3.86 Binds estrogens, fatty acids and metals o IPI00365752.4 COAGULATION FACTOR XII. s 1.66 o IPI00366226.3 s 2.21 o IPI00367761.4 ALPHA-2U GLOBULIN. s 11.00 o IPI00368403.3 SIMILAR TO FILAGGRIN 2. s 1.28 o IPI00371986.2 PLAKOPHILIN-1. s 2.06 o IPI00373745.3 s 6.64 o IPI00392753.2 11 KDA PROTEIN. ns 8.34 o IPI00400749.3 s 3.33 o IPI00476458.3 s 5.26 o IPI00558996.2 48 KDA PROTEIN. s 2.41 o IPI00560188.2 14 KDA PROTEIN. s 9.30 o IPI00564368.2 11 KDA PROTEIN. ns 24.24 o IPI00568547.3 ANTHRAX TOXIN RECEPTOR. s 1.56 s 42.74 GLUCOSAMINE (N-ACETYL)-6SULFATASE. SIMILAR TO TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 1. COXSACKIE VIRUS AND ADENOVIRUS RECEPTOR-LIKE 1. GLUTATHIONE PEROXIDASE 3 PRECURSOR. SIMILAR TO PROSTATIC STEROID- o IPI00767210.1 BINDING PROTEIN C1 CHAIN PRECURSOR. Contains 1 peptidase S1 domain Belongs to the lipocalin family Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione C : concanavalin A J : Jacalin W : WGA g : N-glycoproteins confirmed by GlycoSuiteDB, O : O-glycoproteins confirmed by GlycoSuiteDB p : The term 'Probable' is stronger than the qualifier 'Potential' and there must be at least some experimental evidence po : The term 'Potential' indicates that there is some logical or conclusive evidence that the given annotation could apply s : potential glycoproteins predicted by NetNGlyc 1.0. NS : Not signal