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SIRT6, 1-355aa Human, His tagged, Recombinant, E.coli Cat. No. SIR0901 Cat. No. SIR0951 Size: 0.5 mg Size: 100 ug Full name: sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) Synonym: sirtuin 6, SIR2L6 NCBI Accession No: NP_057623 Description: The SIRT6 is included in class IV of the sirtuin family, homologs to the yeast Sir2 protein. The functions of human sirtuins have not yet been determined; however, in yeast sirtuins are known to regulate epigenetic gene silencing. Also SIRT6, a chromatin-associated protein, appears to be involved in DNA repair. Recombinant SIRT6, fused to His-tag at N-terminus, was expressed in E.coli and purified by conventional chromatography techniques. Form: Liquid in 20 mM Tris-HCl pH 8.0, 10% Glycerol Molecular Weight: 41 kDa (375 aa) Purity: > 95% by SDS PAGE Concentration: 1 mg/ml Sequences: MGSSHHHHHH SSGLVPRGSH MSVNYAAGLS PYADKGKCGL PEIFDPPEEL ERKVWELARL VWQSSSVVFH TGAGISTASG IPDFRGPHGV WTMEERGLAP KFDTTFESAR PTQTHMALVQ LERVGLLRFL VSQNVDGLHV RSGFPRDKLA ELHGNMFVEE CAKCKTQYVR DTVVGTMGLK ATGRLCTVAK ARGLRACRGE LRDTILDWED SLPDRDLALA DEASRNADLS ITLGTSLQIR (kDa) PSGNLPLATK RRGGRLVIVN LQPTKHDRHA DLRIHGYVDE VMTRLMEHLG LEIPAWDGPR 70 VLERALPPLP RPPTPKLEPK EESPTRINGS IPAGPKQEPC AQHNGSEPAS PKRERPTSPA PHRPPKRVKA KAVPS 40 28 General references: Michishita E., et al. (2008) Nature. 27;452(7186):492-6 18 Mostoslavsky R., et al. (2006) Cell. 27;124(2):315-29. 13.5 Storage: Store at -20℃. Avoid freeze/thaw cycle 15% SDS-PAGE