Download Name: DNA Stations Once Mendel`s work was rediscovered in the

Name: ___________________________________
DNA Stations
Once Mendel’s work was rediscovered in the 1900’s, many scientists wanted to search for the molecule involved in the
inheritance. Scientists knew the genetic information was carried on the chromosomes in eukaryotic cells, and that two
main components of chromosomes are DNA and protein. For many years, scientists tried to determine which of these
macromolecules—nucleic acid (DNA) or proteins—was the source of genetic information.
Station 1—Griffith’s Mouse Experiments
Read the section on Griffith on page 326
1. What year did Frederick Griffith do his first major experiment? __________
2. What is the strain of bacteria (Streptococcus pneumoniae) called that causes pneumonia? _____________________
3. What is the strain called that does not? _______________
Fill in the blanks in the picture below. Virulent means causing disease.
7. Griffith found that the disease-causing factor was passed from the ________________________________________
to the ______________________________________________, showing that the genetic material was able to be
transformed, meaning it could be _____________________________________________________________________.
Station 2—Oswald Avery (make sure to do station 1 before coming here)
8.
What kind of educational background did Avery have?
9. What became Avery’s main focus of study after he learned about Griffith’s mouse experiment?
10. What are three macromolecules Avery thought might hold the genetic information?
11. What happened when the S cells were killed?
12. What was Avery’s ultimate finding?
Station 3--Hershey and Chase
Watch the video and answer the questions as you go. You may need to watch it more than once.
A little background info: Bacteriophages are viruses that infect bacteria. Although they are not living, they do contain
DNA. At the time no one knew whether the genetic material was DNA or protein. To find out, Hershey and Chase
radioactively labeled proteins, then DNA. They wanted to see which was instrumental in producing new phages inside
the bacteria, which then infect that bacteria.
13. What did Hershey and Chase use to demonstrate DNA was the genetic material?
What did these consist of?
14. When phages affect bacteria, they inject what into the bacteria?
15. What part of the phage was radioactively labeled during the first experiment?
16. The phages were then allowed to what?
17. Where did the radioactive material end up?
18. In the second group of phages, which part of the phase was labeled with radioactivity?
19. Where did the radioactive material end up this time?
20. What did these experiments demonstrate?
Station 4--Watson and Crick
21. What nationality was Watson?
Crick?
22. In what year did Watson and Crick publish their famous study?
21. Where did they get their idea?
23. What do you suppose “posthumously” means?
Station 5—Rosalind Franklin
16. Why didn’t Franklin’s father want her to be a scientist?
17. How did Maurice Wilkins treat Franklin?
18. How was she beaten to publication by Watson and Crick?
19. In your opinion, who should get credit for discovering the double-helix model of DNA?
Why?
Station 6—DNA
Use the book for help, if you need it.
22. What does DNA stand for?
23. What are the three parts of DNA?
24. Explain how a double helix relates to a chromosome. You may either draw a picture or explain in words.
Station 7—BrainPop DNA
Watch the BrainPop video on DNA. When you’re done, take the graded quiz at the end. Once your quiz is
graded call Ms. Prehn over to initial here: __________
Station 8—Crossword Puzzle
Do Station 7 only after you have finished all other stations!