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Wellness and Illness Wellness and Illness • Cell Pathology – understanding dysfunction of the body’s heirarchy – studied at the microscope level 1) examine cells 2) measure cell metabolism using chemical or genetic testing Cell Pathology Biopsy → identifying conditions 1) amyloid deposition 2) atrophy 3) dysplasia 4) dystrophy 5) fatty change 6) hyperplasia 7) hypertrophy 8) metaplasia 9) metastasis 10) necrosis Cell Pathology amyloid deposition • accumulation of amyloids in a cell – amyloidosis • amyloidosis usually results in cell death • Alzheimer’s is an example of amyloid deposition Cell Pathology atrophy • decrease in size of cell, tissue, or organ • due to undernutrition, blood flow problems • muscle atrophy is the result of nerve damage or lack of muscle use. Cell Pathology dysplasia • disorderly growth pattern in a tissue or organ • not cancerous • significant impact on function of the affected body structure Cell Pathology dystrophy • “ill growth” • progressive changes in tissue • due to 1) long term malnutrition 2) undernutrition 3) decreased blood flow Cell Pathology fatty change • accumulation of lipids in the cell due to cellular injury • ↑ alcohol → fat accumulation in liver cells • fat continues to build up in cell’s organelles until it disrupts normal cell and tissue function Cell Pathology hyperplasia • abnormal multiplication of the number of cells in a tissue • arrangement and distribution of cells in the tissue not affected • ↑ risk of certain cancers • distorts the function of the tissue or organ Cell Pathology hypertrophy • enlargement of a tissue or organ • NOT due to cell number, but cell size • distorts tissue or organ function • disrupts homeostasis Cell Pathology metaplasia • change in cell and tissue function from normal to abnormal • can be reversible – one cell type replaced by another cell type → inappropriate functioning of tissue or organ • caused by: – DNA damage – exposure to hazardous chemicals • long term metaplasia can result in cancer due to breakdown in cell communication and tissue organization Cell Pathology metastasis • restricted to highly abnormal cells → cancerous • diseased cells break away from the original location in the body and establish themselves in a new area – carry out abnormal functions in new location Cell Pathology necrosis • localized tissue death • results from – blood flow decrease – burns – chemical damage – infection – injury • results in deceased function of tissue, organ, and organ system Wellness and Illness Cellular Aging As we know, cellular aging = the accumulation of molecular decay Occurs 2 ways 1) cytoplasmic damage 2) DNA damage Cellular Aging No mitosis in: a) fat cells b) skeletal muscle c) nervous tissue Mitosis = minor DNA damage repairs made Over a lifetime → cells accumulate years of damage in cytoplasm = accumulated cell damage Cellular Aging Cells with accumulated cell damage eventually fail at performing normal tasks → negatively affects other tissues and organ systems The effects of accumulated cell damage are increased by: a) hazardous chemicals b) pollution c) smoking d) radiation e) ultraviolet light f) viruses g) stress Cellular Aging Too much chemical damage = premature death due to: 1) metabolic malfunction 2) apoptosis Cellular Aging Cells that do replicate (mitosis) accumulate different damage • DNA damaged every S phase (mostly deletions) • After several hundred rounds of mitosis these cells may function abnormally due to accumulation of mutations – digestive – respiratory – integumentary Cellular Aging • These changes can lead to cancer, especially if genes related to mitosis are damaged • Additionally, every mitosis shortens the end of chromosomes (telomeres) • No genes on telomeres, but too much telomere shortening → abnormal chromosome structure → malfunction or apoptosis Cellular Aging • Hypothesis that telomere shortening = molecular clock • Telomere shortening DOES NOT occur in cancer cells Cellular Aging apoptosis – normal cell death scheduled by genetic programming, that does not affect surrounding cells Stress releases body chemicals that contribute to decay • chemicals bind to DNA ↑ altered gene expression dysfunction biologists → abnormal, impaired, or incomplete functioning of an organism, organ system, organ, tissue, or cell – almost all gross diseases are the result of dysfunction in one or more tissues in an organ system biopsy the removal of diseased cells for study amyloid • proteinlike material • intended to be beneficial for cell, but harmful when build up in cytoplasm • indicate cell damage