* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download Macromolecules
Magnesium transporter wikipedia , lookup
Self-assembling peptide wikipedia , lookup
Endomembrane system wikipedia , lookup
Nucleic acid analogue wikipedia , lookup
Bottromycin wikipedia , lookup
Protein (nutrient) wikipedia , lookup
Metalloprotein wikipedia , lookup
Genetic code wikipedia , lookup
Protein domain wikipedia , lookup
Protein folding wikipedia , lookup
Homology modeling wikipedia , lookup
Western blot wikipedia , lookup
Protein moonlighting wikipedia , lookup
Expanded genetic code wikipedia , lookup
Fatty acid synthesis wikipedia , lookup
Interactome wikipedia , lookup
Two-hybrid screening wikipedia , lookup
Biosynthesis wikipedia , lookup
Nuclear magnetic resonance spectroscopy of proteins wikipedia , lookup
Cell-penetrating peptide wikipedia , lookup
Fatty acid metabolism wikipedia , lookup
Circular dichroism wikipedia , lookup
Protein adsorption wikipedia , lookup
Intrinsically disordered proteins wikipedia , lookup
Protein–protein interaction wikipedia , lookup
List of types of proteins wikipedia , lookup
Compare and Contrast inorganic and organic molecules Carbon Dioxide (CO2) Glucose (C6H12O6) Water (H2O) Methane (CH4) 4 Major Macromolecules - • Proteins • Carbohydrates • Nucleic acids • Lipids These organic molecules comprise approximately 25% of all living organisms ! Contrast the terms monomer and polymer Monomers are the building blocks of polymers Ex: Amino Acids -> Proteins (Polypeptides) How do we build and breakdown macromolecules? How do we build and breakdown macromolecules? Monomers: monosaccharides Monomers: monosaccharides Covalently Joining Monosaccharides together… How does variation in molecular building blocks provide cells with a wider range of functions? How does variation in molecular building blocks provide cells with a wider range of functions? Starches—major energy storage molecule in plants Glycogen—major energy storage molecule in animals Cellulose—major structural component of “plant-like” cell walls **These polysaccharides are ALL comprised entirely of glucose monomers** Images of Three Major Polysaccharides How are lipids different from carbohydrates, even though they are composed of the same three elements? Lipids are insoluble in water because of many nonpolar covalent bonds. Widest Variation among molecules Functions… Figure 2.12 Saturated Fatty Acid (Part 1) Figure 2.12 Unsaturated Fatty Acid (Part 2) Explain the difference between a saturated fatty acid and an unsaturated fatty acid. Structure function relationship… Saturated versus Unsaturated Fatty Acids… THINK ABOUT IT: At night, the cotton plant can avoid freezing by increasing the number of unsaturated fatty acids in its cell membranes… How does this enhance its survival? Figure 2.13 B Phospholipids Nucleic Acids: Monomers - Nucleotides 3 components of a Nucleotide: Polymers of Nucleic Acids: Examples! The CENTRAL DOGMA OF BIOLOGY! DNA->RNA->Protein A change in DNA sequence can affect all levels of organism function! Amino Acids: The building blocks of proteins 20 different types in most biological systems Same general structure with a variable “R” group Covalently bonding Amino Acids to form a Protein: The four levels of protein structure – Due to its extreme complexity Primary structure: The sequence of amino acids in a polypeptide chain Interactions: Peptide Bonds Concept 3.2 Proteins Are Polymers with Important Structural and Metabolic Roles Secondary structure – helices and pleated sheet structures seen in proteins Interactions: H-bonds between H of one amino acid and O of nonadjacent a.a.s Concept 3.2 Proteins Are Polymers with Important Structural and Metabolic Roles Tertiary structure: Specific, unique 3D structure of a protein Interactions: R-group interactions between each other and the environment Ex: nonpolar attractions, + and – attractions, hydrophilic interactions with water Figure 3.9 The Structure of a Protein Quarternary Structure Quaternary structure—Structure that results from multiple polypeptide chains interacting (ex: insulin, hemoglobin) Digestive Enzymes!! How can changes in molecular units of proteins result in a wider range of function? Fetal versus Adult hemoglobin: Antibody Diversity Denaturation: Which level of protein structure would be disrupted first? Which level of protein structure would be the hardest to disrupt? Changes in the environment resulting in changes in the 3D structure of a protein -> disrupts function Tertiary disrupted first; Primary hardest to disrupt THINK ABOUT IT: How did this lesson demonstrate the relationship between structure and function of biological molecules? Shape determines function is a MAJOR theme in biology. What determines the shape of these organic compounds?