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chromosomes: compact molecules of DNA A human set of chromosomes contains 23 pairs, half from mom, half from dad 23rd pair are your sex chromosomes Karyotype Genes are units of heredity that are passed on from parent to offspring (two copies, one from each parent) Genes give specific instructions for proteins proteins give traits ex. widow’s peak, skin tone, etc Environment can be a factor in traits as well* https://www.youtube.com/watch?v=ubq4eu_T DFc Genome: All of our hereditary information. A complete set of human gene instructions. Gene: portion of DNA that codes for a protein, ex. oncogene the genome (and genes) is made of DNA DNA -DeoxyriboNucleic Acid -what chromosomes are made of -the hereditary material inherited from past generations, what chromosomes are made of -The vast majority ( >99%) of your DNA is in the nucleus of your cells 1. DNA Structure - double helix - the sides of the ladder are made of alternating deoxyribose sugar and phosphate molecules -the rungs of the ladder are made of nucleotides held together by hydrogen bonds A-T G-C A always binds to T C always binds to G DNA RNA Protein very similar to DNA, but ◦ single stranded ◦ complementary base to adenine is not thymine, as it is in DNA, but rather uracil. A–U G-C cellular machines made from small units called amino acids carry out tasks, like controlling the cell cycle! 1. DNA RNA DNA (double stranded) is transcribed in the NUCLEUS with the aid of an enzyme called RNA polymerase. a) RNA polymerase unwinds and unlinks the two strands of DNA. b) The TEMPLATE strand will be used by RNA polymerase. RNA polymerase adds the RNA base compliment to the DNA template to make the RNA For example: TACGGGAGTCTC The newly formed RNA strand is SINGLE STRANDED. It leaves the nucleus and enters the cytoplasm The next step is Translation! 2. RNA ______________ Occurs in the cytoplasm with the aid of a ribosome. Each RNA codes for amino acids. The RNA is read by reading the codon sequence. ◦ A codon is 3 BASE PAIRS LONG. Each codon codes for an amino acid. RNA strand: AUGGUUAUUGCG For example: AUGCCCUCAGAG RNA strand: AUGGUUAUUGCG The appropriate amino acid is placed on the growing polypeptide chain. The polypeptide chain then undergoes structural changes to become a functional protein! If we change the DNA: ◦ RNA will be changed = Protein will be changed This is what we take advantage of in biotechnology!