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Download Illumina Infinium HumanMethylation450 BeadChip Data
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Illumina® Infinium HumanMethylation450 BeadChip Methylation Workflow for Illumina BeadChip Partek has developed the only third-party analysis workflow for the Illumina® Infinium® HumanMethylation450 BeadChip used in epigenomic research. Access the workflow through Partek® Genomics Suite™ software where you can perform analysis in a single, user-friendly application. Start by importing native .idat files directly into Partek Genomics Suite and applying innovative techniques for signal processing, background correction, and normalization. Follow with secondary analysis using powerful embedded statistics and visualizations to yield deep biological interpretation. Going from raw data to biological interpretation has never been easier. Exploratory analysis using Principal Component Analysis (PCA) for detection of sample grouping and outliers. • Import raw .idat files and perform background correction • Filter probes by chromosome, single-nucleotide polymorphism (SNP), copy number variant (CNV) regions, multiple mapping, and detection p-values • Normalize data with Illumina normalization and SWAN methods • Perform exploratory analysis with principal component analysis (PCA), clustering, partial least squares (PLS), and multidimensional scaling (MDS) • Apply inferential statistics of methylated loci at the individual level and across experimental conditions to compare islands Hierarchical clustering analysis of significant differentially methylated genomic regions. • Visualize with hierarchical clustering, 2D/3D dot-plots, profile trellis, chromosome view, and more • Integrate with other data-types, such as mRNA/miRNA expression, SNP/CNV, and ChIP • Interpret biological meaning with pathway and gene ontology analysis Partek is a registered trademark of Partek Incorporated. copyright of Kanehisa Laboratories. Under license from Pathway Solutions Inc. Copyright © 2015 Partek Incorporated. St. Louis, MO. Pathway analysis of genes, which had been found to be targeted by differential methylation using Partek® Pathway™. North America: +1.314.878.2329 Europe: +44 (0) 2075 588491 Asia/Australasia: +65-64789730 [email protected] | www.partek.com Partek® Genomics Suite® Workflows for Illumina® Data Partek Genomics Suite has workflows for the following Illumina assays to provide you one platform for all your genomic data analysis needs. RNA Sequencing Next Generation Sequencing* Differential Gene Expression • Small RNA-Seq • Alternative Splicing • Fusion Transcripts • Coding SNPs/eQTL • DNA Sequencing Candidate Genes • Whole Genome • Exome • Gene Regulation Copy Number • DNA Methylation • ChIP-Seq • ncRNA Gene Expression • Microarray Micro RNA Association/Trio Allele Specific Copy Number LOH Copy Number DNA Methylation *Partek Genomics Suite accepts any aligned NGS data in BAM/SAM formats. When alignment is performed with Partek® Flow® software the results are seamlessly imported into Partek Genomics Suite. Partek is a registered trademark of Partek Incorporated. All other brands or product names mentioned are trademarks owned by their respective companies or organizations. Copyright © 2015 Partek Incorporated. St. Louis, MO. • • • • • • •