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KRISHANU RAY’S LAB DEPARTMENT OF BIOLOGICAL SCIENCES TATA INSTITUTE OF FUNDAMENTAL RESEARCH Research focus Molecular Cell Biology of Intracellular transport Stem cell proliferation and differentiation Drosophila melanogaster Neurons as model system for studying intracellular transport Axon Dendrite Synapse Nucleus Deciding the destinations Motor start and stopping coordination of movements Aparna Sadananda RAB4::mRFP contaning vesicle in the segmental nerve Anuttama Kulkarni AChE in lch5 axons Swagata Dey ChAT in lch5 axon ChAT GFP How does Kinesin-2 transport different cargos in axons? How do the sensory cilia develop & its implications? Drosophila testis as a model to study cell biology of proliferation and differentiation Understanding how microenvironment of cells regulate their fate Stem cell Progenitor cell Amplification Differentiation Differentiated cells The different signalling in the somatic cyst cells and their effects on the transit amplification of the germline stem cell progeny. Pankaj Dubey Mechanism of sperm release in Drosophila testis. What happens when you poke a cell? It reacts by mounting F-actin dynamics at the site. F-actin Sperm head 1 HCC 2 3 4 5 TCC WASp F-actin Spermatid Spermatid nucleus tails Dynamin WASp/Dynamin refractory zone Pankaj Dubey Krishanu Ph.D. M.Sc. Ayan Dipti Anuttama Samir Post Doc. Swagata Chetan Rajarshi JRF Samir Zoheb Purna Tushna Pranali Pooja Priya