Download Curriculum Vitae

Curriculum Vitae
Name
Birth Date
Place of Birth
Citizenship
Xiao-bing Yuan
March 31, 1973
Daye, Hubei, China
China
Mailing address:
Laboratory of Neural Circuit Development,
Institute of Neuroscience, SIBS, CAS
Shanghai 200031, China
Telephone: (86) -21-54921812; Fax: (86) –21-54921735
Email: [email protected]
Education:
1991-1995: Department of Biology, East China Normal University. Bachelor’s degree
1995-2001: Shanghai Brain Research Institute, CAS. Ph.D. degree
Advisor: Professor Mu-ming Poo, Prof. Shumin Duan, Prof. Chien-pin Wu
1999-2000: Biology Department, UCSD. Exchange student
Advisor: Professor Mu-ming Poo
Professional Positions:
2001-2002: Assistant Investigator, Institute of Neuroscience, SIBS, CAS
2003-2004: Associate Investigator, Institute of Neuroscience, SIBS, CAS
2005: Investigator, Institute of Neuroscience, SIBS, CAS
Honors and Services:
2003
Rising star of Science and Technology, Shanghai
2004
Top 100 excellent Ph.D. Dissertation Award of China
2006
National Science Fund for Distinguished Young Scholars of China
2007
9th National Science and Technology Award for Young Scholars of China
2007
Special Government Allowances from State Department of China
2008
Program Committee Local Organization Committee Member of the 8th Biennial
Meeting for APSN
2008
Excellent Mentoring Award, Chinese Academy of Sciences
2009
P&G Excellent Supervisor Award, Chinese Academy of Sciences
2010
Program Committee Member of the 11th Biennial Meeting for APSN
Teaching:
• Stem cell and generation of neurons. Graduate Neurobiology Courses in SIBS (04-08)
• Apoptosis and neurotrophic protection. Graduate Neurobiology Courses in SIBS (04)
• Axon guidance and neuronal migration. Graduate Neurobiology Courses in SIBS (04-10)
• Cell fate determination and neural patterning. Graduate Neurobiology Courses in SIBS (09-10)
Invited Talks (international conferences and symposia):
 11th International Neuroscience Winter Conference, Sölden, Austria, 2009/3/31-4/4
 IBRO 2007 Satellite Meeting “Stem cells, axon guidance, and cell migration in the
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developing and adult brain”, Cairns, Australia, 2007/7/8
The 1st Australia-China Biomedical Research Conference, Melbourne, Australia, 2007/2/1
The 6th Congress of Federation of the Asian and Oceanian Physiological Societies, Seoul,
Korea, 2006/10/18
The 4th International Chinese Neuroscience Symposium, KunMin, 2006/7/3
The 3rd Crouch Advanced Research Institute, Hong Kong University of Science &
Technology 2006/1/18
Sino-Canadian Symposium on Neuroscience, Shanghai, 2005/11/2
Gordon Research Conference, Mechanisms of Cell Signalling, Hong Kong University of
Science & Technology 2005/6/12
CAS-Columbia Symposium on Neuroscience, Shanghai, 2005/5/15
The First Shanghai Symposium on Signal Transduction and Cancer, SIBS, Shanghai,
2004/8/29
The 1st Crouch Advanced Research Institute, Hong Kong University of Science &
Technology 2002/1/12
Research field: Mechanisms underlying the guidance of neuronal migration in developing brain
1. Objectives:
My laboratory was set up in March 2005. The long-term goal of the laboratory is to understand the
molecular mechanisms underlying the proper migration and distribution of different types of
neurons in developing brain, one of the key steps for brain morphogenesis. Currently, we focus on
the guidance mechanism for the radial migration of cortical neurons by diffusible guidance factors
and the intracellular molecular machinery to drive the neuronal migration. A combination of
approaches including single neuron migration assay, embryo electroporation, tissue culture,
molecular manipulations, and optical imaging, are used to tackle these questions. Human genetic
studies showed that many neurological disorders are caused by defects in and neuronal migration
axon pathfinding during development. This line of
study will shed a new light on the diagnosis and
therapy of this group of diseases.
2. Main Topics
(1) Guidance of the cortical radial migration by
extracellular and intracellular factors
Formation of the laminar structure of the mammalian
cerebral cortex requires a well-coordinated migration
of cohorts of post-mitotic neurons along radial glial
fibers from the ventribular zone (VZ) towards
Figure 1. A hypothesis of chemotropic
guidance of cortical radial migration. The
inside-out migration of newborn neurons
(yellow) along the radial glial fibers (white)
may be guided by attractants (red) from
upper layers of CP and repellents (blue)
from VZ. MZ, marginal zone; CP, cortical
plate; SP, subplate; IZ, intermediate zone;
VZ, ventricular zone.
superficial layers of the cortical plate (CP) during early development. We aim to clarify whether a
chemotropic guidance mechanism is also engaged in the proper radial migration and lamination of
cortical neurons (see Figure. 1). Intracellular signaling mechanisms underlying the guidance of
cortical radial migration by diffusible factors are also analyzed.
(2) Molecular machinery underlying the neuronal migration and its guidance
Dissociated culture of cerebellar granule cells exhibits active neuronal migration, and provides an
excellent model system for monitoring the molecular dynamics that correlates with the migratory
behavior of the neuron. We also take advantage of the local rather than global perfusion of
guidance factors and pharmacological agents at different sub-cellular regions of migrating
neurons to dissect how the motilities of different parts of neurons are generated and coordinated
during neuronal migration.
Publications:
1. Ming G, Wong S, Henley J, Yuan XB, Song H, Spitzer N and Poo MM* (2002) Adaptation
in the chemotactic guidance of nerve growth cones. Nature, 417: 411-8.
2. Xiang Y, Li Y, Zhang Z, Cui K, Wang S, Yuan XB, Wu CP, Poo MM, Duan SM* (2002)
Nerve growth cone guidance mediated by G protein coupled receptors. Nature Neurosci., 5:
843-8
3. Yuan XB*, Jin M, Xu X, Song YQ, Wu CP, Poo MM and Duan SM* (2003). Signaling and
crosstalk of rho-GTPases in mediating axon guidance. Nature Cell Biology, 5: 38-45.
4. Wang B, Xiao Y, Ding BB, Zhang N, Yuan X, Gui L, Qian KX, Duan S, Chen Z, Rao Y,
Geng JG* （2003） Induction of tumor angiogenesis by Slit-Robo signaling and inhibition
of cancer growth by blocking Robo activity. Cancer Cell. 4:19-29.
5. Xu H, Yuan XB, Guan C, Duan S, Wu CP, Feng L* (2004) Calcium Signaling in
Slit2-Dependent Regulation of Neuronal Migration. PNAS. 101: 4296-301.
6. Jin M, Guan CB, Jiang YA, Zhao CT, Cui K, Song YQ, Wu CP, Duan SM, Poo MM*, Yuan
XB* (2005) Ca2+-dependent regulation of Rho GTPases can trigger turning of nerve growth
cones. J. Neuroscience, 25: 2338-47.
7. Li Y, Cui K, Jia YC, Li N, Zhen ZY, Wang YZ*, Yuan XB* (2005) Essential role of TRPC
channels in the guidance of nerve growth cone by BDNF. Nature, 14:835-8.
8. Xu X, Fu AK, IP, FC, Wu CP, Duan SM, Poo, MM, Yuan XB, IP NY* (2005) Agrin
regulates growth cone turning of Xenopus spinal motoneurons. Development, 132: 4309-16.
9. Cui K, Yuan XB*. (2006). “TRP channels and axon pathfinding” TRP Ion Channels in
Transduction of Sensory Stimuli and Cellular Signaling Cascades. Chapter 4.
10. Zhang YJ*, Gu XF, Yuan XB (2007) Phenylalanine activates the mitochondria-mediated
apoptosis through the RhoA/Rho-associated kinase pathway in cortical neurons. Europ. J.
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Neurosci. 25: 1341-1348
Guan CB, Xu HT, Jin M, Yuan XB*, and Poo MM* (2007) Long-Range Ca2+ Signaling
from Growth Cone to Soma Mediates Reversal of Neuronal Migration Induced by Slit-2. Cell
129: 385-395.
Ding S, Luo JH, and Yuan, XB* (2007) Semaphorin-3F attracts the growth cone of
cerebellar granule cells through cGMP signaling pathway. Biochem. Biophys. Res. Commun.
356: 857-863.
Zhang YJ*, Zhang HW, Yuan XB, Gu XF (2007) Differential effects of phenylalanine on
Rac1, Cdc42, and RhoA expression and activity in cultured cortical neurons. Pediatric
Research 62: 8-13.
Chen G, Sima J, Jin M, Zheng W, Wang KY, Xue XJ, Ding YQ, Yuan XB* (2008)
Semaphorin-3A guides radial migration of cortical neurons during development. Nature
Neurosci., 11: 36-44.
Zheng W, Yuan XB* (2008).Guidance of cortical radial migration by gradient of diffusible
factors. Cell Adhesion and Migraiton, 2: 48-50 (extraview).
Huang ZH, Wang Y, Cao L, Su ZD, Zhu YL, Chen YZ, Yuan XB, He C* (2008) Migratory
properties of cultured olfactory ensheathing cells by single-cell migration assay. Cell Res.
18:479-90.
Scolnick JA, Cui K, Duggan CD, Xuan S, Yuan XB, Efstratiadis A, Ngai J*. （2008）Role
of IGF signaling in olfactory sensory map formation and axon guidance. Neuron. 57:847-57.
Samson WK, Zhang JV, Avsian-Kretchmer O, Cui K, Yosten GL, Klein C, Lyu RM, Wang
YX, Chen XQ, Yang J, Price CJ, Hoyda TD, Ferguson AV, Yuan XB, Chang JK, Hsueh AJ*.
(2008) Neuronostatin encoded by the somatostatin gene regulates neuronal, cardiovascular,
and metabolic functions. J. Biol Chem. 283:31949-59.
Ding C, Liang XJ, Ma L, Yuan XB, Zhu XL*. (2009) Opposing effects of Ndel1 and alpha 1
or alpha 2 on cytoplasmic dynein through competitive binding to Lis1 J. Cell Sci. 122:
2820-2827.
Zhang X, Lei K, Yuan X, Wu X, Zhuang Y, Xu T, Xu R, Han M*. (2009) SUN1/2 and
Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and
neuronal migration in mice. Neuron.64:173-87.
Zhao CT, Li K, Li JT, Zheng W, Liang XJ, Geng AQ, Li N, and Yuan XB* (2009) PKCδ
regulates cortical radial migration by stabilizing the Cdk5 activator p35. PNAS. 106:
21353-21358.
Yuan XB* (2010) Axon guidance and neuronal migration research in china. Science China
Life Science. doi: 10.1007/s11427-010-0068-6 (Review)
Li N, Zhao CT, Wang Y, Yuan XB* (2010) The transcription factor Cux1 regulates dendritic
morphology
of
cortical
pyramidal
neurons.
PlosOne
5(5):
e10596.
doi:10.1371/journal.pone.0010596
Xue XJ, Yuan XB* (2010) Nestin Is Essential for Mitogen-stimulated Proliferation of Neural
Progenitor Cells. Mol. Cell. Neurosci. doi: 10.1016/j.mcn.2010.05.006.
He M, Zhang ZH, Guan CB, Xia D, Yuan XB* (2010) Leading tip drives soma translocation
via forward F-actin flow during neuronal migration. J. Neurosci. (in press)