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Principal Investigator/Program Director (Last, First, Middle):
Amieva, Manuel, Ricardo
BIOGRAPHICAL SKETCH
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Manuel Amieva
Assistant Professor of Pediatrics & Microbiology
and Immunology
eRA COMMONS USER NAME
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
Dartmouth College, Hanover, NJ
Stanford University, Stanford, CA
DEGREE
(if applicable)
A.B.
M.D./Ph.D.
YEAR(s)
FIELD OF STUDY
1982-1986 Biology
1988-1997 Med Doc & Cancer
Biology
Positions and Employment
1997-1999
Resident in Pediatrics, Lucille Packard Children Hospital at Stanford
1999-2002
Pediatric Infectious Disease Fellow, Stanford Medical Center
2000- 2004
Post Doctoral Fellow, Stanford University School of Medicine
2004Assistant Professor of Pediatrics & Microbiology and Immunology, Stanford University
Honors
1985-1985
1986
1986
1988-1997
2000
2000-2004
2005-2006
2005-2007
2006
Sigma Xi Undergraduate Research Award. Award given by the Scientific Research
Honor Society to the best undergraduate research in the Biological Sciences.
Phi Beta Kappa. National Honor Society
Biology Degree from Dartmouth College with High Honors. Magna Cum Laude.
Medical Scientist Training Program Scholarship. Medical and Research training
scholarship funded by the National Institute of Health
Awarded Pfizer Postdoctoral Fellowship in Infectious Diseases 2000. Award declined
because of coincident PIDS/St. Jude Award
Pediatric Infectious Diseases Society / St. Jude Fellowship in Pediatric Infectious
Diseases
Named Investigator Award- Stanford University Digestive Disease Center
MedImmune Career Development Award in Pediatric Infectious Diseases
Pediatric Infectious Diseases Society Young Investigator Award
Boards
American Board of Pediatrics- Board Certified 2003 - 2010 (ABP #077410)
Pediatric Infectious Diseases- Board Certified 2005 - 2012 (ABP ID# 616739)
Publications
1. Amieva, MR, Reed CG and Pawlik JR. 1987. Ultrastructure and behavior of the larva of Phragmatopoma
californica (Polychaeta: Sabellariidae): identification of sensory organs potentially involved in substrate
selection. Marine Biology. 95:259-266.
2. Amieva, MR and Reed CG. 1987. Functional morphology of the larval tentacles of Phragmatopoma
californica (Polychaeta: Sabellariidae): composite larval and adult organs of multifunctional significance.
Marine Biol. 95:243-258.
3. Marin-Padilla, M; Amieva, MR. 1989. Early neurogenesis of the mouse olfactory nerve: Golgi and electron
microscopic studies. J Comp Neurol. 288(2):339-352.
PHS 398/2590 (Rev. 09/04, Reissued 4/2006)
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Principal Investigator/Program Director (Last, First, Middle):
Amieva, Manuel, Ricardo
4. Furthmayr H, Lankes W, and Amieva, MR. 1992. Moesin a new cytoskeletal protein and constituent of
filopodia its role in cellular functions. Kidney Int. 41:665-670.
5. Amieva MR, Wilgenbus KK, and Furthmayr H. 1994. Radixin is a component of hepatocyte microvilli in situ.
Expel Cell Res. 210:140-144.
6. Pestonjamasp K, Amieva MR, Strassel CP, Nauseef WM, Furthmayr H, and Luna EJ. 1995. Moesin, ezrin,
and p205 are actin-binding proteins associated with neutrophil plasma membranes. Molec Biol Cell. 6:247-259.
7. Amieva MR and Furthmayr H. 1995. Subcellular localization of moesin in dynamic filopodia, retraction
fibers, and other structures involved in substrate exploration, attachment, and cell-cell contacts. Exper Cell
Res. 219:180-196.
8. Nakamura F, Amieva MR, and Furthmayr H. 1995. Phosphorylation of threonine 558 in the carboxylterminal actin-binding domain of moesin by thrombin activation of human platelets. J Biol Chem. 270:3137731385.
9. Hugo C, Hugo C, Pichler R Gordon K, Schmidt R, Amieva MR, Couser WG, Furthmayr H, and Johnson R.
1996. The cytoskeletal linking proteins, moesin and radixin, are upregulated by platelet-derived growth factor,
but not basic fibroblast growth factor in experimental mesangial proliferative glomerulonephritis. J Clin Invest.
97:2499-2508.
10. Hirota C, Mizuno Y, Amieva MR, Furthmayr H, and Nakamura F. 1996. Phosphorylation of 558T of moesin
detected by site-specific antibodies in RAW264.7 macrophages. Biochem. Biophys. Res. Commun. 226:650656.
11. O'Toole EA, Marinkovich MP, Peavey CL, Amieva MR, Furthmayr H, Mustoe TA, and Woodley DT. 1997.
Hypoxia increases human keratinocyte motility on connective tissue. J Clin Invest, 100:2881-91.
12. Hugo C, Nangaku M, Shankland SJ, Pichler R, Gordon K, Amieva MR, Couser WG, Furthmayr H, and
Johnson RJ. 1998. The plasma membrane-actin linking protein, ezrin, is a glomerular epithelial cell marker in
glomerulogenesis, in the adult kidney and in glomerular injury. Kidney Int. 54:1934-44.
13. Amieva MR, Litman P, Huang L, Ichimaru E, and Furthmayr H. 1999. Disruption of dynamic cell surface
architecture of NIH3T3 fibroblasts by the N-terminal domains of moesin and ezrin: in vivo imaging with GFP
fusion proteins. J Cell Sci. 112:111-25.
14. Litman P, Amieva MR, and Furthmayr H. 2000. Imaging of Dynamic Changes of the Actin Cytoskeleton in
Microextensions of Live NIH3T3 Cells with a GFP Fusion of the F-Actin Binding Domain of Moesin. BMC Cell
Biol. 1:1.
15. Amieva MR, Salama NR, Tompkins LS, and Falkow S. 2002. Helicobacter pylori enter and survive within
multivesicular vacuoles of epithelial cells. Cellular Microbiol. 4:677-90.
16. Amieva MR, Vogelmann R, Covacci A, Tompkins LS, Nelson WJ, and Falkow, S. 2003. Disruption of the
epithelial apical-junctional complex by Helicobacter pylori CagA. Science. 300:1430-34.
17. Vogelmann R, Amieva MR, Falkow S and Nelson WJ. 2004. Breaking into the epithelial apical-junctional
complex – news from pathogen hackers. Curr Opin Cell Biol 16:86-93.
18. Bagnoli F, Buti L, Tompkins L, Covacci A, and Amieva MR. 2005. Helicobacter pylori CagA induces a
transition from polarized to invasive phenotypes in MDCK cells. Proc. Natl. Acad. Sci USA 102:16339-44.
19. Mueller A, Falkow S, and Amieva MR. 2005. Helicobacter pylori and gastric cancer: What can be learned
by studying the response of gastric epithelial cells to the infection? Cancer Epidemiol Biomarkers Prev.
14:1859-64.
20. Amieva MR. 2005. Important bacterial gastrointestinal pathogens in children: A pathogenesis
perspective. Pediatr Clin North Am. 52:749-77.
21. Pentecost M, Otto G, Theriot JA, and Amieva, MR. Listeria monocytogenes invades the epithelial junctions
at sites of cell extrusion. PLoS Pathogens. 2006. Jan (2)1:e3.
PHS 398/2590 (Rev. 09/04, Reissued 4/2006)
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